Ephedrine/ guaifenesin syrup

Generic Name: ephedrine/guaifenesin (eh-FED-rin/gwye-FEN-ah-sin)
Brand Name: Broncholate

Ephedrine/ guaifenesin syrup is used for:

Relieving congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Ephedrine/guaifenesin syrup is a decongestant and expectorant combination. It works by constricting blood vessels, reducing swelling in the nasal passages, and thinning and loosening mucus in the airway. This allows you to breathe more easily and makes coughs more productive.

Do NOT use ephedrine/ guaifenesin syrup if:

  • you are allergic to any ingredient in ephedrine/guaifenesin syrup
  • you have severe high blood pressure, rapid heartbeat, or other severe heart problems (eg, heart blood vessel disease)
  • you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: OTC Medication Use In Pregnancy: Wise or Worrisome?

Before using ephedrine/ guaifenesin syrup:

Some medical conditions may interact with ephedrine/guaifenesin syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a fast, slow, or irregular heartbeat
  • if you have a history of adrenal gland problems (eg, tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, an enlarged prostate or other prostate problems, seizures, or an overactive thyroid
  • if you have chronic cough

Some MEDICINES MAY INTERACT with ephedrine/guaifenesin syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects from ephedrine/guaifenesin syrup may be increased
  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Bromocriptine because the risk of side effects may be increased by ephedrine/guaifenesin syrup
  • Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by ephedrine/guaifenesin syrup

This may not be a complete list of all interactions that may occur. Ask your health care provider if ephedrine/guaifenesin syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use ephedrine/ guaifenesin syrup:

Use ephedrine/guaifenesin syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

  • Ephedrine/guaifenesin syrup may be taken with or without food.
  • Take ephedrine/guaifenesin syrup with a full glass of water unless otherwise directed by your doctor.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of ephedrine/guaifenesin syrup, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use ephedrine/guaifenesin syrup.

Important safety information:

  • Ephedrine/guaifenesin syrup may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to ephedrine/guaifenesin syrup. Using ephedrine/guaifenesin syrup alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Do not take appetite suppressants while you are taking ephedrine/guaifenesin syrup without checking with your doctor.
  • Ephedrine/guaifenesin syrup contains ephedrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains ephedrine. If it does or if you are uncertain, contact your doctor or pharmacist.
  • Do NOT exceed the recommended dose or take ephedrine/guaifenesin syrup for longer than prescribed without checking with your doctor.
  • If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.
  • Ephedrine/guaifenesin syrup may interfere with certain lab test results. Make sure that all of your doctors and laboratory personnel know that you are taking ephedrine/guaifenesin syrup.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using ephedrine/guaifenesin syrup.
  • Use ephedrine/guaifenesin syrup with caution in the ELDERLY because they may be more sensitive to its effects.
  • Caution is advised when using ephedrine/guaifenesin syrup in CHILDREN because they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking ephedrine/guaifenesin syrup, discuss with your doctor the benefits and risks of using ephedrine/guaifenesin syrup during pregnancy. It is unknown if ephedrine/guaifenesin syrup is excreted in breast milk. Do not breast-feed while taking ephedrine/guaifenesin syrup.

Possible side effects of ephedrine/ guaifenesin syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of ephedrine/guaifenesin syrup:

Store ephedrine/guaifenesin syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep ephedrine/guaifenesin syrup out of the reach of children and away from pets.

General information:

  • If you have any questions about ephedrine/guaifenesin syrup, please talk with your doctor, pharmacist, or other health care provider.
  • Ephedrine/guaifenesin syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about ephedrine/guaifenesin syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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