Enalaprilat

Generic Name: enalaprilat (en-AL-a-pril-AT)
Brand Name: Generic only. No brands available.

Enalaprilat may cause injury or death to the fetus if used during pregnancy. If you think you may be pregnant, contact your doctor right away. If you are planning to become pregnant, talk with your doctor about other treatment options.


Enalaprilat is used for:

Treating high blood pressure in patients unable to take enalaprilat by mouth. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor. It works by helping to relax blood vessels. This helps to lower blood pressure.

Do NOT use enalaprilat if:

  • you are allergic to any ingredient in enalaprilat
  • you are pregnant
  • you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an ACE inhibitor (eg, lisinopril)
  • you are taking a medicine that contains aliskiren and you also have diabetes or kidney problems. Check with your doctor or pharmacist if you are not sure if a medicine you take contains aliskiren
  • you are taking dextran sulfate

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: View Frightful (But Dead Serious) Drug Side Effects

Before using enalaprilat:

Some medical conditions may interact with enalaprilat. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are able to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart problems (eg, aortic stenosis, heart failure), blood vessel problems (eg, in the heart or brain), blood flow problems, bone marrow problems, diabetes, or kidney problems (eg, renal artery stenosis)
  • if you have a history of stroke, recent heart attack, or kidney transplant
  • if you are receiving dialysis or apheresis treatments, or are scheduled to have surgery or receive anesthesia
  • if you have low blood sodium levels, high blood potassium levels, the blood disease porphyria, or an autoimmune disease (eg, lupus, rheumatoid arthritis, scleroderma)
  • if you are dehydrated, have low blood volume, or are on a low-salt (sodium) diet
  • if you are receiving treatments to reduce sensitivity to bee or wasp stings

Some MEDICINES MAY INTERACT with enalaprilat. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood pressure may be increased
  • Everolimus or sirolimus because the risk of angioedema may be increased
  • Dextran sulfate because it may increase the risk of allergic reaction (eg, rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) and light-headedness upon standing
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, ibuprofen, naproxen) because they may decrease enalaprilat's effectiveness, and the risk of kidney damage may be increased
  • Certain gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure may occur
  • Lithium or thiopurines (eg, azathioprine) because the risk of their side effects may be increased by enalaprilat
  • Aliskiren or angiotensin receptor blockers (eg, losartan) because the risk of certain side effects (eg, kidney problems, high blood potassium levels, low blood pressure) may be increased
  • Eplerenone, potassium-sparing diuretics (eg, amiloride), potassium supplements, or trimethoprim because the risk of high blood potassium levels may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if enalaprilat may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use enalaprilat:

Use enalaprilat as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Enalaprilat is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using enalaprilat at home, a health care provider will teach you how to use it. Be sure you understand how to use enalaprilat. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use enalaprilat if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of enalaprilat, contact your doctor right away.

Ask your health care provider any questions you may have about how to use enalaprilat.

Important safety information:

  • Enalaprilat may cause dizziness or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use enalaprilat with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Enalaprilat may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. If light-headedness occurs, especially during the first few days of treatment, contact your doctor.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.
  • Enalaprilat may cause a dry, unproductive cough. If caused by enalaprilat, this symptom usually stops after treatment with enalaprilat is stopped.
  • Enalaprilat may cause a serious side effect called angioedema. The risk may be higher in black patients. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
  • Enalaprilat may not work as well in black patients. Contact your doctor if your symptoms do not improve or if they become worse.
  • Enalaprilat may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to enalaprilat. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Rarely, enalaprilat may lower the ability of your body to fight infection. This risk may be greater if you have certain other health problems (eg, kidney problems, collagen vascular disease). Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Tell your doctor or dentist that you take enalaprilat before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including blood pressure monitoring, blood electrolyte levels, and kidney function, may be performed while you take enalaprilat. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Enalaprilat should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Enalaprilat may cause birth defects or fetal death if you use it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Enalaprilat is found in breast milk. If you are or will be breast-feeding while you take enalaprilat, check with your doctor. Discuss any possible risks to your baby. Do not breast-feed while taking enalaprilat.

Possible side effects of enalaprilat:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; persistent, dry cough.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); chest pain; decreased urination; fast, slow, or irregular heartbeat; mental or mood changes; red, swollen, blistered, or peeling skin; shortness of breath; stomach pain (with or without nausea or vomiting); symptoms of infection (eg, fever, chills, sore throat); symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, yellowing of the skin or eyes); symptoms of low blood pressure (eg, fainting, severe dizziness, light-headedness); unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe dizziness or light-headedness.

Proper storage of enalaprilat:

Store enalaprilat at room temperature below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep enalaprilat out of the reach of children and away from pets.

General information:

  • If you have any questions about enalaprilat, please talk with your doctor, pharmacist, or other health care provider.
  • Enalaprilat is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take enalaprilat or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about enalaprilat. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to enalaprilat. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using enalaprilat.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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