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Doxepin cream

Pronunciation

Generic Name: doxepin (DOX-e-pin)
Brand Name: Zonalon

Doxepin cream is used for:

Relieving moderate itching caused by certain skin conditions.

Doxepin cream is an antipruritic cream. It is not known exactly how it works. It may block histamine to relieve itching.

Do NOT use doxepin cream if:

  • you are allergic to any ingredient in doxepin cream
  • you have certain prostate problems (eg, asymptomatic prostatic hypertrophy), uncontrolled glaucoma, or trouble urinating (urinary retention)
  • you are taking clonidine, an H1 antagonist (eg, astemizole, terfenadine), or ibutilide
  • you have taken linezolid or a monoamine oxidase inhibitor (MAOI) (eg, furazolidone, phenelzine, isocarboxazid) within the past 14 days

Contact your doctor or health care provider right away if any of these apply to you.

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Before using doxepin cream:

Some medical conditions may interact with doxepin cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart problems, seizures (eg, epilepsy), overactive thyroid, glaucoma or increased pressure in the eyes, prostate problems (eg, benign prostatic hypertrophy [BPH]), certain blood problems (eg, porphyria), suicidal thoughts or attempts, or a history of alcohol abuse
  • if you are taking a medicine that contains methylene blue

Some MEDICINES MAY INTERACT with doxepin cream. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antiarrhythmics (eg, quinidine, propafenone, flecainide), antifungal medicines (eg, fluconazole, terbinafine), carbamazepine, cimetidine, mibefradil, phenothiazines (eg, chlorpromazine, thioridazine), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine, sertraline) because they may increase the risk of doxepin cream's side effects
  • Anticoagulants (eg, warfarin), clonidine, guanadrel, H1 antagonists (eg, astemizole, terfenadine), ibutilide, sulfonylureas (eg, tolazamide, glipizide), sympathomimetics (eg, phenylephrine, pseudoephedrine), or tramadol because the risk of their side effects may be increased by doxepin cream
  • Clonidine, guanadrel, guanethidine, or guanfacine because their effectiveness may be decreased by doxepin cream
  • Linezolid or MAOIs (eg, furazolidone, phenelzine, isocarboxazid) because severe toxic effects may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if doxepin cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use doxepin cream:

Use doxepin cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Doxepin cream is for external use only.
  • Wash and completely dry the affected area. Apply a thin film to the affected area and gently rub it in.
  • Wash your hands immediately after using doxepin cream, unless they are part of the treated area.
  • Do not bandage or otherwise cover the treated area unless directed to do so by your doctor. Avoid tight-fitting clothes on the treated area.
  • If you miss a dose of doxepin cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use doxepin cream.

Important safety information:

  • Doxepin cream may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use doxepin cream with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Doxepin cream will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • Limit your alcohol consumption while taking doxepin cream.
  • Avoid getting doxepin cream in your eyes or on the inside of your nose or mouth.
  • Use doxepin cream with caution in the ELDERLY; they may be more sensitive to its effects, especially drowsiness and confusion.
  • Doxepin cream should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using doxepin cream while you are pregnant. It is not known if doxepin cream is found in breast milk. Do not breast-feed while taking doxepin cream.

Possible side effects of doxepin cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; burning and stinging at the application site; changes in emotions; confusion; dizziness; drowsiness; dry and tight skin; dry mouth and lips; fatigue; headache; itching; swelling; taste changes; thirst.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; rapid or pounding heartbeat; severe burning and stinging at the application site.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Doxepin cream may be harmful if swallowed.

Proper storage of doxepin cream:

Store doxepin cream at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep doxepin cream out of the reach of children and away from pets.

General information:

  • If you have any questions about doxepin cream, please talk with your doctor, pharmacist, or other health care provider.
  • Doxepin cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take doxepin cream or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about doxepin cream. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to doxepin cream. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using doxepin cream.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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