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Diltiazem 24-hour sustained-release capsules

Pronunciation

Generic Name: diltiazem (dil-TYE-a-zem)
Brand Name: Examples include Diltia XT and Dilt-XR

Diltiazem 24-hour sustained-release capsules is used for:

Treating high blood pressure and chronic stable angina (chest pain). It may be used alone or in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Diltiazem 24-hour sustained-release capsules is a calcium channel blocker. It works by relaxing (dilating) your blood vessels, lowering blood pressure, and decreasing heart rate, which lowers the workload of the heart. It also dilates coronary arteries, which increases blood flow to the heart.

Do NOT use diltiazem 24-hour sustained-release capsules if:

  • you are allergic to any ingredient in diltiazem 24-hour sustained-release capsules
  • you have certain heart problems (eg, sick sinus syndrome, second- or third-degree heart block) and do not have a pacemaker, you have very low blood pressure, or you have fluid buildup in the lungs during or soon after a heart attack
  • you are taking erythromycin

Contact your doctor or health care provider right away if any of these apply to you.

Before using diltiazem 24-hour sustained-release capsules:

Some medical conditions may interact with diltiazem 24-hour sustained-release capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart failure, a recent heart attack with lung congestion, heart block, a very slow heart rate, or other heart problems; low blood pressure; certain stomach or intestine problems (eg, narrowing); liver disease; or kidney problems
  • if you are taking other medicines for high blood pressure or heart conditions

Some MEDICINES MAY INTERACT with diltiazem 24-hour sustained-release capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antiarrhythmics (eg, amiodarone, dronedarone), cimetidine, clonidine, HIV protease inhibitors (eg, atazanavir, indinavir), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of diltiazem 24-hour sustained-release capsules's side effects, such as heart rhythm problems
  • Benzodiazepines (eg, alprazolam), beta-blockers (eg, propranolol), buspirone, carbamazepine, cilostazol, cisapride, colchicine, corticosteroids (eg, hydrocortisone), cyclosporine, digoxin, everolimus, fentanyl, HMG-CoA reductase inhibitors (eg, simvastatin), hydantoins (eg, phenytoin), lurasidone, macrolide antibiotics (eg, erythromycin ), macrolide immunosuppressants (eg, tacrolimus), nifedipine, quinidine, ranolazine, theophylline, or vasopressin antagonists (eg, tolvaptan) because the risk of their side effects, some potentially life-threatening, may be increased by diltiazem 24-hour sustained-release capsules
  • Moricizine or rifamycins (eg, rifampin) because they may decrease diltiazem 24-hour sustained-release capsules's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if diltiazem 24-hour sustained-release capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use diltiazem 24-hour sustained-release capsules:

Use diltiazem 24-hour sustained-release capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take diltiazem 24-hour sustained-release capsules by mouth on an empty stomach at least 1 hour before or 2 hours after eating.
  • Swallow diltiazem 24-hour sustained-release capsules whole. Do not open, break, crush, or chew before swallowing.
  • Taking diltiazem 24-hour sustained-release capsules at the same time each day will help you remember to take it.
  • Continue to take diltiazem 24-hour sustained-release capsules even if you feel well. Do not miss any doses.
  • If you miss a dose of diltiazem 24-hour sustained-release capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use diltiazem 24-hour sustained-release capsules.

Important safety information:

  • Diltiazem 24-hour sustained-release capsules may cause dizziness, lightheadedness, or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use diltiazem 24-hour sustained-release capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Diltiazem 24-hour sustained-release capsules may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Diltiazem 24-hour sustained-release capsules may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to diltiazem 24-hour sustained-release capsules. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • Do not suddenly stop taking diltiazem 24-hour sustained-release capsules. Your condition may get worse if you suddenly stop taking it. If you need to stop diltiazem 24-hour sustained-release capsules or add a new medicine, your doctor will gradually lower your dose.
  • Tell your doctor or dentist that you take diltiazem 24-hour sustained-release capsules before you receive any medical or dental care, emergency care, or surgery.
  • Be sure to have your blood pressure checked regularly while taking diltiazem 24-hour sustained-release capsules.
  • Lab tests, including blood pressure, electrocardiogram (ECG), and heart rate, may be performed while you use diltiazem 24-hour sustained-release capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use diltiazem 24-hour sustained-release capsules with caution in the ELDERLY; they may be more sensitive to its effects, especially swelling of the ankles, feet, or hands; dizziness; and slow heartbeat.
  • Diltiazem 24-hour sustained-release capsules should be used with extreme caution in CHILDREN; safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking diltiazem 24-hour sustained-release capsules while you are pregnant. Diltiazem 24-hour sustained-release capsules is found in breast milk. Do not breast-feed while taking diltiazem 24-hour sustained-release capsules.

Possible side effects of diltiazem 24-hour sustained-release capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; facial flushing; headache; lightheadedness; tiredness; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; mental or mood changes; personality changes; reddened, blistered, or swollen skin; severe or persistent dizziness, lightheadedness, nausea, or vomiting; shortness of breath; sudden weight gain; swelling of the feet, ankles, or hands; symptoms of liver problems (eg, dark urine, pale stools, yellowing of the skin or eyes); tender, bleeding, or swollen gums; unusual bleeding or bruising; unusual or persistent tiredness or weakness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; difficulty breathing, especially when lying down; dizziness; drowsiness; fainting; lightheadedness, especially when standing; loss of consciousness; nausea; nervousness; slurred speech; unusual weakness; very slow heart rate.

Proper storage of diltiazem 24-hour sustained-release capsules:

Store diltiazem 24-hour sustained-release capsules at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep diltiazem 24-hour sustained-release capsules out of the reach of children and away from pets.

General information:

  • If you have any questions about diltiazem 24-hour sustained-release capsules, please talk with your doctor, pharmacist, or other health care provider.
  • Diltiazem 24-hour sustained-release capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take diltiazem 24-hour sustained-release capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about diltiazem 24-hour sustained-release capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to diltiazem 24-hour sustained-release capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using diltiazem 24-hour sustained-release capsules.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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