Digex NF

Generic Name: hyoscyamine/phenyltoloxamine (HYE-oh-SYE-a-meen/FEN-il-tole-OX-a-meen)
Brand Name: Digex NF

Digex NF is used for:

Relieving symptoms of indigestion (eg, feeling of fullness, gas, bloating). It is also used to treat certain stomach and intestinal conditions, including spasms and cramps. It may also be used for other conditions as determined by your doctor.

Digex NF is an anticholinergic and antihistamine combination. It works by decreasing the motion of muscles in the stomach, intestines, and bladder. It also decreases the production of stomach acid.

Do NOT use Digex NF if:

  • you are allergic to any ingredient in Digex NF
  • you have severe esophagus problems (eg, irritation, narrowing); a blockage of the stomach, bowel, or bladder; bowel motility problems; or severe bowel problems (eg, severe ulcerative colitis, toxic megacolon)
  • you have glaucoma, myasthenia gravis, or heart problems caused by severe bleeding
  • you are taking sodium oxybate (GHB)
  • you are taking potassium chloride capsules or tablets

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Digex NF:

Some medical conditions may interact with Digex NF. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have lung or breathing problems (eg, asthma), nerve problems, prostate problems, esophagus problems (eg, reflux), stomach or bowel problems, heart or blood vessel problems (eg, fast or irregular heartbeat, heart failure, coronary heart disease), hiatal hernia, kidney problems, an overactive thyroid, high blood pressure, urinary problems, paralysis, or brain damage, or if you are at risk for glaucoma
  • if you have diarrhea or fever, have trouble urinating, have been very ill, or are in poor health

Some MEDICINES MAY INTERACT with Digex NF. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Potassium tablets or capsules because they may not be able to move through the stomach and bowel as well when taken with Digex NF; this may increase the risk of their side effects
  • Narcotic pain medicines (eg, codeine) because the risk of their side effects may be increased by Digex NF
  • Amantadine, antihistamines (eg, diphenhydramine), haloperidol, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), other anticholinergics (eg, scopolamine), phenothiazines (eg, thioridazine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Digex NF's side effects
  • Ketoconazole or metoclopramide because their effectiveness may be decreased by Digex NF

This may not be a complete list of all interactions that may occur. Ask your health care provider if Digex NF may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Digex NF:

Use Digex NF as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Digex NF by mouth with food as directed by your doctor.
  • If you also take antacids, take Digex NF before meals and the antacid after meals, unless directed otherwise by your doctor.
  • If you open the capsule, do not breathe in the powder. Some patients may experience an allergic reaction (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) from breathing in the powder.
  • If you miss a dose of Digex NF, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Digex NF.

Important safety information:

  • Digex NF may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Digex NF with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Digex NF; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke may occur.
  • Drink plenty of fluids, maintain good oral hygiene, and suck on sugarless hard candy to relieve dry mouth.
  • Proper dental care is important while you are taking Digex NF. Brush and floss your teeth and visit the dentist regularly.
  • Digex NF may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
  • Tell your doctor or dentist that you take Digex NF before you receive any medical or dental care, emergency care, or surgery.
  • Use Digex NF with caution in the ELDERLY; they may be more sensitive to its effects, especially constipation, trouble urinating, dry mouth, drowsiness, agitation, confusion, excitability, or memory problems.
  • Caution is advised when using Digex NF in CHILDREN; they may be more sensitive to its effects, including excitability.
  • PREGNANCY and BREAST-FEEDING: It is not known if Digex NF can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Digex NF while you are pregnant. Digex NF is found in breast milk. If you are or will be breast-feeding while taking Digex NF, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Digex NF:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloated feeling; blurred vision; constipation; decreased sweating; dizziness; drowsiness; dry mouth; enlarged pupils; excitability; headache; nausea; nervousness; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; behavior changes; confusion; decreased sexual ability; diarrhea; difficulty focusing eyes; disorientation; exaggerated sense of well-being; fast or irregular heartbeat; fever; hallucinations; loss of consciousness; loss of coordination; memory loss; mental or mood changes; severe or persistent trouble sleeping; speech changes; taste changes or loss; trouble urinating; unusual tiredness or weakness; vision changes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include disorientation; excessive thirst or excitability; fever; hot, dry skin; seizures; severe dry mouth; severe or persistent blurred vision, dizziness, headache, nausea, or vomiting; trouble breathing or swallowing.

Proper storage of Digex NF:

Store Digex NF at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Digex NF out of the reach of children and away from pets.

General information:

  • If you have any questions about Digex NF, please talk with your doctor, pharmacist, or other health care provider.
  • Digex NF is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Digex NF or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Digex NF. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Digex NF. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Digex NF.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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