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Dextromethorphan/ chlorpheniramine/ methscopolamine

Generic Name: dextromethorphan/chlorpheniramine/methscopolamine (DEX-troe-meth-OR-fan/KLOR-fen-IR-a-meen/METH-skoe-POL-a-meen)
Brand Name: Generic only. No brands available.

Dextromethorphan/ chlorpheniramine/ methscopolamine is used for:

Relieving coughing, sneezing, runny nose, and itchy, watery eyes due to colds, upper respiratory infections, or allergies. It may also be used for other conditions as determined by your doctor.

Dextromethorphan/chlorpheniramine/methscopolamine is an antihistamine, anticholinergic and cough suppressant combination. The antihistamine works by blocking histamine, a substance in the body that causes sneezing, runny nose, and itchy, watery eyes. The anticholinergic works by drying the mucous membranes in the nose and chest. The cough suppressant works in the brain to help decrease the cough reflex to reduce coughing.

Do NOT use dextromethorphan/ chlorpheniramine/ methscopolamine if:

  • you are allergic to any ingredient in dextromethorphan/chlorpheniramine/methscopolamine
  • you have bladder blockage, heart disease, increased eye pressure or glaucoma, muscle weakness (eg, myasthenia gravis), overactive thyroid, severe bowel problems (eg, toxic megacolon), severe esophagus problems (eg, reflux esophagitis), severe high blood pressure
  • you are taking sodium oxybate (GHB) or a selective serotonin reuptake inhibitor (SSRI) (eg, fluoxetine)
  • you are taking or have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days

Contact your doctor or health care provider right away if any of these apply to you.

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Before using dextromethorphan/ chlorpheniramine/ methscopolamine:

Some medical conditions may interact with dextromethorphan/chlorpheniramine/methscopolamine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a hiatal hernia; diabetes; esophagus problems (eg, reflux disease); high blood pressure; irregular heartbeat, congestive heart failure, or other heart problems; overactive thyroid; stomach or bowel problems (eg, blockage, constipation, motility problems, ulcerative colitis); or increased eye pressure, glaucoma, or you are at risk of developing glaucoma
  • if you have a history of bladder or kidney problems, prostate gland problems (eg, enlarged prostate), or trouble urinating
  • if you have a history of asthma, chronic cough, lung or breathing problems (eg, chronic bronchitis, emphysema, sleep apnea, slow or irregular breathing), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus
  • if you have a history of alcohol abuse
  • if you take potassium chloride tablets

Some MEDICINES MAY INTERACT with dextromethorphan/chlorpheniramine/methscopolamine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Furazolidone, MAOIs (eg, phenelzine) or sodium oxybate (GHB) because the risk of serious side effects, such as high blood pressure or severe drowsiness, may be increased
  • SSRIs (eg, fluoxetine) because the risk of a serious side effect called serotonin syndrome may be increased. Symptoms of serotonin syndrome may include diarrhea, fast heartbeat, fever, hallucinations, increased sweating, loss of coordination, mental or mood changes, muscle spasms, nausea, or vomiting
  • Anticholinergic medicines (eg, benztropine), barbiturates (eg, phenobarbital), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of dextromethorphan/chlorpheniramine/methscopolamine's side effects
  • Butyrophenones (eg, haloperidol) because their effectiveness may be decreased by dextromethorphan/chlorpheniramine/methscopolamine

This may not be a complete list of all interactions that may occur. Ask your health care provider if dextromethorphan/chlorpheniramine/methscopolamine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use dextromethorphan/ chlorpheniramine/ methscopolamine:

Use dextromethorphan/chlorpheniramine/methscopolamine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take dextromethorphan/chlorpheniramine/methscopolamine by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Swallow dextromethorphan/chlorpheniramine/methscopolamine whole. Do not crush or chew before swallowing. Some brands of dextromethorphan/chlorpheniramine/methscopolamine may be broken in half before taking. If you have difficulty swallowing the whole tablet, ask your pharmacist if your brand of medicine may be broken in half.
  • Drinking extra fluids while you are taking dextromethorphan/chlorpheniramine/methscopolamine is recommended. Check with your doctor for instructions.
  • Do not take an antacid or medicine for diarrhea within 1 hour before or 2 hours after you take dextromethorphan/chlorpheniramine/methscopolamine.
  • If you miss a dose of dextromethorphan/chlorpheniramine/methscopolamine and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use dextromethorphan/chlorpheniramine/methscopolamine.

Important safety information:

  • Dextromethorphan/chlorpheniramine/methscopolamine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use dextromethorphan/chlorpheniramine/methscopolamine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using dextromethorphan/chlorpheniramine/methscopolamine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do NOT take more than the recommended dose without checking with your doctor.
  • If your cough or other symptoms persist for more than 1 week, come back, or if you also have a fever, rash, or persistent headache, check with your doctor.
  • Do not use dextromethorphan/chlorpheniramine/methscopolamine for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.
  • Dextromethorphan/chlorpheniramine/methscopolamine may cause dry mouth. To relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute.
  • Dextromethorphan/chlorpheniramine/methscopolamine may reduce sweating. Do not become overheated in hot weather or during exercise or during other activities; heatstroke may occur.
  • Dextromethorphan/chlorpheniramine/methscopolamine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to dextromethorphan/chlorpheniramine/methscopolamine. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Dextromethorphan/chlorpheniramine/methscopolamine may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking dextromethorphan/chlorpheniramine/methscopolamine for a few days before the tests.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using dextromethorphan/chlorpheniramine/methscopolamine.
  • Dextromethorphan/chlorpheniramine/methscopolamine has chlorpheniramine and dextromethorphan in it. Before you start any new medicine, check the label to see if it has chlorpheniramine and dextromethorphan in it too. If it does or you are not sure, check with your doctor or pharmacist.
  • Use dextromethorphan/chlorpheniramine/methscopolamine with caution in the ELDERLY; they may be more sensitive to its effects especially confusion, blurred vision, dry mouth, lightheadedness, difficulty urinating, or loss of bladder control.
  • Dextromethorphan/chlorpheniramine/methscopolamine should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
  • Caution is advised when using dextromethorphan/chlorpheniramine/methscopolamine in CHILDREN; they may be more sensitive to its effects, especially excitability.
  • PREGNANCY and BREAST-FEEDING: It is not known if dextromethorphan/chlorpheniramine/methscopolamine can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using dextromethorphan/chlorpheniramine/methscopolamine while you are pregnant. It is not known if dextromethorphan/chlorpheniramine/methscopolamine is found in breast milk. Do not breast-feed while taking dextromethorphan/chlorpheniramine/methscopolamine.

Possible side effects of dextromethorphan/ chlorpheniramine/ methscopolamine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; change in appetite; constipation; dizziness; drowsiness; dry mouth, nose, or throat; excitability (especially in children); headache; lightheadedness; nausea; nervousness; restlessness; stomach upset or pain; tiredness; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty swallowing; difficulty urinating; fast, slow, or irregular heartbeat; flushing; hallucinations; increased irritability or excitability; memory problems; seizures; severe clumsiness; severe dizziness, drowsiness, headache, or lightheadedness; sore throat; unusual tiredness or weakness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include difficulty breathing; extreme dizziness; extreme drowsiness; fixed/large pupils or involuntary eye movements; hot, dry skin; irregular heartbeat; loss of consciousness; loss of coordination; mental or mood changes; persistent vomiting; ringing in the ears; seizures.

Proper storage of dextromethorphan/chlorpheniramine/methscopolamine:

Store at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep dextromethorphan/chlorpheniramine/methscopolamine out of the reach of children and away from pets.

General information:

  • If you have any questions about dextromethorphan/chlorpheniramine/methscopolamine, please talk with your doctor, pharmacist, or other health care provider.
  • Dextromethorphan/chlorpheniramine/methscopolamine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take dextromethorphan/chlorpheniramine/methscopolamine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about dextromethorphan/chlorpheniramine/methscopolamine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to dextromethorphan/chlorpheniramine/methscopolamine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using dextromethorphan/chlorpheniramine/methscopolamine.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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