Dexbrompheniramine/ dextromethorphan/ phenylephrine liquid

Generic Name: dexbrompheniramine/dextromethorphan/phenylephrine (DEX-brome-fen-IR-a-meen/DEX-troe-meth-OR-fan/FEN-il-EF-rin)
Brand Name: Examples include Panatuss DXP and Supress A

Dexbrompheniramine/ dextromethorphan/ phenylephrine liquid is used for:

Relieving symptoms of sinus congestion, runny nose, sneezing, itchy nose or throat, itchy or watery eyes, and cough due to colds, upper respiratory infections, or allergies. It may also be used for other conditions as determined by your doctor.

Dexbrompheniramine/dextromethorphan/phenylephrine liquid is a nasal decongestant, antihistamine, and cough suppressant combination. The nasal decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.

Do NOT use dexbrompheniramine/ dextromethorphan/ phenylephrine liquid if:

  • you are allergic to any ingredient in dexbrompheniramine/dextromethorphan/phenylephrine liquid
  • you have severe or uncontrolled high blood pressure, severe heart blood vessel disease, fast heartbeat, or severe heart problems
  • you are unable to urinate or are having an asthma attack
  • you are taking droxidopa, sodium oxybate (GHB), or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: OTC Medication Use In Pregnancy: Wise or Worrisome?

Before using dexbrompheniramine/ dextromethorphan/ phenylephrine liquid:

Some medical conditions may interact with dexbrompheniramine/dextromethorphan/phenylephrine liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have phenylketonuria (PKU)
  • if you have a history of adrenal gland problems (eg, adrenal gland tumor), heart problems (eg, fast, slow, or irregular heartbeat; heart disease), high or low blood pressure, low blood volume, diabetes, blood vessel problems, a stroke, glaucoma or increased pressure in the eye, thyroid problems, or trouble sleeping
  • if you have a history of asthma, chronic cough, lung or breathing problems (eg, chronic bronchitis, emphysema, sleep apnea), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus
  • if you have a history of stomach or bowel ulcers; a blockage of your stomach, bladder, or bowel; kidney problems; trouble urinating; or an enlarged prostate or other prostate problems

Some MEDICINES MAY INTERACT with dexbrompheniramine/dextromethorphan/phenylephrine liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Abiraterone, beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, linezolid, MAOIs (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of dexbrompheniramine/dextromethorphan/phenylephrine liquid's side effects
  • Bromocriptine or hydantoins (eg, phenytoin) because their side effects may be increased by dexbrompheniramine/dextromethorphan/phenylephrine liquid
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by dexbrompheniramine/dextromethorphan/phenylephrine liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if dexbrompheniramine/dextromethorphan/phenylephrine liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use dexbrompheniramine/ dextromethorphan/ phenylephrine liquid:

Use dexbrompheniramine/dextromethorphan/phenylephrine liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take dexbrompheniramine/dextromethorphan/phenylephrine liquid by mouth with or without food. If upset stomach occurs, take with food to reduce stomach irritation.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of dexbrompheniramine/dextromethorphan/phenylephrine liquid and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use dexbrompheniramine/dextromethorphan/phenylephrine liquid.

Important safety information:

  • Dexbrompheniramine/dextromethorphan/phenylephrine liquid may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use dexbrompheniramine/dextromethorphan/phenylephrine liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol while you are taking dexbrompheniramine/dextromethorphan/phenylephrine liquid.
  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking dexbrompheniramine/dextromethorphan/phenylephrine liquid; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do not take diet or appetite control medicines while you are taking dexbrompheniramine/dextromethorphan/phenylephrine liquid without checking with your doctor.
  • Before you start any new medicine, check the label to see if it has a decongestant, antihistamine, or cough suppressant in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Some of these products contain phenylalanine. If you must have a diet that is low in phenylalanine, ask your pharmacist if it is in your product.
  • Do not use dexbrompheniramine/dextromethorphan/phenylephrine liquid for a cough with a lot of mucus. Do not use it for a chronic cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If new symptoms occur, if your symptoms do not improve within 7 days, if they get worse or return, or if they occur along with a fever, rash, or persistent headache, check with your doctor.
  • Dexbrompheniramine/dextromethorphan/phenylephrine liquid may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to dexbrompheniramine/dextromethorphan/phenylephrine liquid. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Dexbrompheniramine/dextromethorphan/phenylephrine liquid may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking dexbrompheniramine/dextromethorphan/phenylephrine liquid for a few days before the tests.
  • Tell your doctor or dentist that you take dexbrompheniramine/dextromethorphan/phenylephrine liquid before you receive any medical or dental care, emergency care, or surgery.
  • Use dexbrompheniramine/dextromethorphan/phenylephrine liquid with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, drowsiness, dizziness, dry mouth, nervousness, sleeplessness, and trouble urinating.
  • Caution is advised when using dexbrompheniramine/dextromethorphan/phenylephrine liquid in CHILDREN; they may be more sensitive to its effects, especially excitability.
  • Different brands of dexbrompheniramine/dextromethorphan/phenylephrine liquid may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.
  • Dexbrompheniramine/dextromethorphan/phenylephrine liquid should not be used in CHILDREN younger than 6 years old without first checking with the child's doctor; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using dexbrompheniramine/dextromethorphan/phenylephrine liquid while you are pregnant. Some ingredients of dexbrompheniramine/dextromethorphan/phenylephrine liquid are found in breast milk. Do not breast-feed while taking dexbrompheniramine/dextromethorphan/phenylephrine liquid.

Possible side effects of dexbrompheniramine/ dextromethorphan/ phenylephrine liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; loss of coordination; mental or mood changes (eg, depression, nervousness); seizures; severe or persistent dizziness, drowsiness, light-headedness, or headache; severe dryness of mouth, nose, and throat; severe or persistent trouble sleeping; shortness of breath; tremor; unusual bruising or bleeding; unusual tiredness or weakness; vision problems (eg, double vision, severe or persistent blurred vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; flushing; hallucinations; mental or mood changes; muscle spasms; seizures; severe dizziness, light-headedness, or headache; severe drowsiness; trouble breathing; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of dexbrompheniramine/dextromethorphan/phenylephrine liquid:

Store dexbrompheniramine/dextromethorphan/phenylephrine liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep dexbrompheniramine/dextromethorphan/phenylephrine liquid out of the reach of children and away from pets.

General information:

  • If you have any questions about dexbrompheniramine/dextromethorphan/phenylephrine liquid, please talk with your doctor, pharmacist, or other health care provider.
  • Dexbrompheniramine/dextromethorphan/phenylephrine liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take dexbrompheniramine/dextromethorphan/phenylephrine liquid or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about dexbrompheniramine/dextromethorphan/phenylephrine liquid. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to dexbrompheniramine/dextromethorphan/phenylephrine liquid. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using dexbrompheniramine/dextromethorphan/phenylephrine liquid.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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