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Desloratadine/ pseudoephedrine sustained-release tablets

Generic Name: desloratadine/pseudoephedrine (DES-lor-A-ta-deen/SOO-doe-e-FED-rin)
Brand Name: Examples include Clarinex-D 12 Hour and Clarinex-D 24 Hour

Desloratadine/ pseudoephedrine sustained-release tablets is used for:

Temporarily relieving symptoms of hay fever or respiratory allergies, such as stuffy or runny nose, sneezing, itchy or watery eyes, itchy nose or throat, or sinus congestion or pressure. It may also be used for other conditions as determined by your doctor.

Desloratadine/pseudoephedrine sustained-release tablets is an antihistamine and decongestant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The decongestant promotes sinus and nasal drainage, which relieves congestion and pressure.

Do NOT use desloratadine/ pseudoephedrine sustained-release tablets if:

  • you are allergic to any ingredient in desloratadine/pseudoephedrine sustained-release tablets or to similar medicines (eg, loratadine)
  • you have narrow-angle glaucoma, severe high blood pressure, a rapid heartbeat, severe heart problems, severe heart/blood vessel disease (coronary artery disease), or severe difficulty urinating
  • you are taking droxidopa or have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
  • you have experienced serious side effects such as irregular heart rhythms with decongestants (eg, pseudoephedrine, phenylephrine)

Contact your doctor or health care provider right away if any of these apply to you.

Video: Asthma

How to prevent and treat an asthma attack.

Before using desloratadine/ pseudoephedrine sustained-release tablets:

Some medical conditions may interact with desloratadine/pseudoephedrine sustained-release tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of high blood pressure, heart or blood vessel problems, diabetes, kidney or liver problems, glaucoma, seizures, stroke, adrenal gland problems, an enlarged prostate or other prostate problems, trouble sleeping, or an overactive thyroid

Some MEDICINES MAY INTERACT with desloratadine/pseudoephedrine sustained-release tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Furazolidone or MAOIs (eg, phenelzine) because side effects, such as headache, fever, and severe high blood pressure, may occur
  • Digoxin or droxidopa because irregular heartbeat or heart attack may occur
  • Beta-blockers (eg, propranolol), guanadrel, guanethidine, methyldopa, or reserpine because their effectiveness may be decreased by desloratadine/pseudoephedrine sustained-release tablets
  • Bromocriptine because its side effects or toxic effects may be increased by desloratadine/pseudoephedrine sustained-release tablets
  • Urinary alkalinizers (eg, sodium bicarbonate) because they may increase the actions and the risk of desloratadine/pseudoephedrine sustained-release tablets's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if desloratadine/pseudoephedrine sustained-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use desloratadine/ pseudoephedrine sustained-release tablets:

Use desloratadine/pseudoephedrine sustained-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with desloratadine/pseudoephedrine sustained-release tablets. Talk to your pharmacist if you have questions about this information.
  • Take desloratadine/pseudoephedrine sustained-release tablets by mouth with or without food.
  • Swallow desloratadine/pseudoephedrine sustained-release tablets whole. Do not break, crush, or chew before swallowing.
  • If you miss a dose of desloratadine/pseudoephedrine sustained-release tablets and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use desloratadine/pseudoephedrine sustained-release tablets.

Important safety information:

  • Desloratadine/pseudoephedrine sustained-release tablets may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use desloratadine/pseudoephedrine sustained-release tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If your symptoms do not get better within 7 days, or if they get worse, check with your doctor.
  • Desloratadine/pseudoephedrine sustained-release tablets has pseudoephedrine in it. Before you start any new medicine, check the label to see if it has pseudoephedrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Before you begin taking any new medicines, either prescription or nonprescription, check with your doctor or pharmacist. This includes any medicines that contain appetite suppressants, antihistamines, or decongestants.
  • Desloratadine/pseudoephedrine sustained-release tablets may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking desloratadine/pseudoephedrine sustained-release tablets for a few days before the tests.
  • Use desloratadine/pseudoephedrine sustained-release tablets with caution in the ELDERLY; they may be more sensitive to its effects.
  • Desloratadine/pseudoephedrine sustained-release tablets should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using desloratadine/pseudoephedrine sustained-release tablets while you are pregnant. Desloratadine/pseudoephedrine sustained-release tablets is found in breast milk. Do not breast-feed while taking desloratadine/pseudoephedrine sustained-release tablets.

Possible side effects of desloratadine/ pseudoephedrine sustained-release tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Coughing; dizziness; drowsiness; dry mouth; excitability; fatigue; headache; loss of appetite; mild stomach upset; nausea; nervousness; sleeplessness; sore throat; thirst; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; difficulty urinating; fast/irregular heartbeat; mental/mood changes (eg, anxiety, delusions, hallucinations); seizures; severe dizziness; shortness of breath; uncontrolled shaking or tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include high fever; fast, slow, or irregular heartbeat; loss of consciousness; mental or mood changes (eg, hallucinations); seizures; severe drowsiness or dizziness; trouble breathing; unusual nervousness or excitement.

Proper storage of desloratadine/pseudoephedrine sustained-release tablets:

Store desloratadine/pseudoephedrine sustained-release tablets at 77 degrees F (25 degrees C). Avoid exposure to temperatures above 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep desloratadine/pseudoephedrine sustained-release tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about desloratadine/pseudoephedrine sustained-release tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Desloratadine/pseudoephedrine sustained-release tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take desloratadine/pseudoephedrine sustained-release tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about desloratadine/pseudoephedrine sustained-release tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to desloratadine/pseudoephedrine sustained-release tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using desloratadine/pseudoephedrine sustained-release tablets.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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