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Generic Name: daptomycin (DAP-toe-MYE-sin)
Brand Name: Cubicin

Cubicin is used for:

Treating infections caused by certain bacteria. It may also be used for other conditions as determined by your doctor.

Cubicin is an antibiotic. It works by killing sensitive bacteria.

Do NOT use Cubicin if:

  • you are allergic to any ingredient in Cubicin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cubicin:

Some medical conditions may interact with Cubicin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have muscle problems, nerve problems, liver problems, kidney problems, or bowel problems caused by antibiotic use

Some MEDICINES MAY INTERACT with Cubicin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • HMG-CoA reductase inhibitors (eg, atorvastatin) or warfarin because the risk of their side effects may be increased by Cubicin
  • Tobramycin because its effectiveness may be decreased by Cubicin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cubicin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cubicin:

Use Cubicin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Cubicin is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Cubicin at home, a health care provider will teach you how to use it. Be sure you understand how to use Cubicin. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Cubicin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • To clear up your infection completely, use Cubicin for the full course of treatment. Keep using it even if you feel better in a few days.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Cubicin, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Cubicin.

Important safety information:

  • Cubicin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Cubicin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Cubicin only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Be sure to use Cubicin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Long-term or repeated use of Cubicin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Eosinophilic pneumonia, a rare but serious condition, has been reported with the use of Cubicin. Contact your doctor right away if you experience new or worsening fever, cough, shortness of breath, or trouble breathing. Discuss any questions or concerns with your doctor.
  • Cubicin may interfere with certain lab tests, including the PT/INR blood test. Be sure your doctor and lab personnel know you are using Cubicin.
  • Lab tests, including white blood cell counts and creatine phosphokinase, may be performed while you use Cubicin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Cubicin with caution in the ELDERLY; they may be more sensitive to its effects.
  • Cubicin should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cubicin while you are pregnant. Cubicin is found in breast milk. If you are or will be breast-feeding while you use Cubicin, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Cubicin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; headache; nausea; pain, swelling, or redness at the injection site; sore throat; sweating; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; chest pain; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or watery stools; change in the amount of urine produced; fever; muscle pain or weakness, especially in the forearms or lower legs; numbness or tingling; severe or persistent diarrhea; stomach cramps/pain; swelling (eg, of the hands, ankles, feet); symptoms of eosinophilic pneumonia (eg, new or worsening fever, cough, shortness of breath, or trouble breathing); unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Cubicin:

Cubicin is usually handled and stored by a health care provider. If you are using Cubicin at home, store Cubicin as directed by your pharmacist or health care provider. Keep Cubicin out of the reach of children and away from pets.

General information:

  • If you have any questions about Cubicin, please talk with your doctor, pharmacist, or other health care provider.
  • Cubicin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Cubicin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Cubicin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Cubicin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Cubicin.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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