Cosyntropin

Generic Name: cosyntropin (KOE-sin-TROE-pin)
Brand Name: Cortrosyn

Cosyntropin is used for:

Helping doctors diagnose adrenal gland problems (eg, Addison disease, adrenal insufficiency caused by steroid use, tumors). It may also be used for other conditions as determined by your doctor.

Cosyntropin is a man-made (synthetic) portion of the natural hormone corticotropin (ACTH). It works by stimulating the adrenal cortex to produce and secrete adrenocortical hormones.

Do NOT use cosyntropin if:

  • you are allergic to any ingredient in cosyntropin
  • you are using interleukin-2 (eg, aldesleukin)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using cosyntropin:

Some medical conditions may interact with cosyntropin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney disease

Some MEDICINES MAY INTERACT with cosyntropin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low electrolyte (eg, potassium, sodium) levels may be increased
  • Itraconazole because it may increase the risk of cosyntropin's side effects
  • Carbamazepine because it may decrease cosyntropin's effectiveness
  • Anticoagulants (eg, warfarin) because their effectiveness may be decreased and the risk of their side effects may be increased by cosyntropin
  • Interleukin-2 (eg, aldesleukin), mifepristone, quinolones (eg, levofloxacin), or ritodrine because the risk of their side effects may be increased by cosyntropin

This may not be a complete list of all interactions that may occur. Ask your health care provider if cosyntropin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use cosyntropin:

Use cosyntropin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Cosyntropin is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using cosyntropin at home, a health care provider will teach you how to use it. Be sure you understand how to use cosyntropin. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use cosyntropin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of cosyntropin, contact your doctor right away.

Ask your health care provider any questions you may have about how to use cosyntropin.

Important safety information:

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using cosyntropin while you are pregnant. It is not known if cosyntropin is found in breast milk. If you are or will be breast-feeding while you use cosyntropin, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of cosyntropin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Redness or swelling at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fast, slow, or irregular heartbeat; severe or persistent headache or dizziness; swelling of the hands, ankles, or feet.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of cosyntropin:

Cosyntropin is usually handled and stored by a health care provider. If you are using cosyntropin at home, store cosyntropin as directed by your pharmacist or health care provider. Keep cosyntropin out of the reach of children and away from pets.

General information:

  • If you have any questions about cosyntropin, please talk with your doctor, pharmacist, or other health care provider.
  • Cosyntropin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take cosyntropin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about cosyntropin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to cosyntropin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using cosyntropin.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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