Generic Name: coagulation factor xiii concentrate (human) (koe-AG-yoo-LAY-shun FAK-tor THUR-teen)
Brand Name: Corifact
Corifact is used for:
Preventing bleeding in patients with congenital factor XIII (FXIII) deficiency.
Corifact is a human clotting factor derived from human plasma. It works by increasing the amount of clotting FXIII in the blood, which helps the blood form clots more normally and prevent bleeding.
Do NOT use Corifact if:
- you are allergic to any ingredient in Corifact or to other products that are made from human plasma
Contact your doctor or health care provider right away if any of these apply to you.
Before using Corifact:
Some medical conditions may interact with Corifact. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a blood clot, are at risk of developing blood clots, or have a history of blood clots
- if you have a history of bleeding problems other than congenital FXIII deficiency
Some MEDICINES MAY INTERACT with Corifact. However, no specific interactions with Corifact are known at this time.
Ask your health care provider if Corifact may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Corifact:
Use Corifact as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Corifact. Talk to your pharmacist if you have questions about this information.
- Corifact is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Corifact at home, a health care provider will teach you how to use it. Be sure you understand how to use Corifact. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Corifact if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Corifact, contact your doctor right away.
Ask your health care provider any questions you may have about how to use Corifact.
Important safety information:
- Some patients have developed antibodies that decrease Corifact's effectiveness. Discuss any questions or concerns with your doctor. Contact your doctor right away if you experience breakthrough bleeding while you are using Corifact.
- Corifact is made from human plasma. There is an extremely low risk of developing a viral infection or Creutzfeldt-Jakob disease (CJD) after using Corifact. Discuss any questions or concerns with your doctor.
- Lab tests, including blood FXIII levels, may be performed while you use Corifact. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Corifact should be used with extreme caution in the ELDERLY; safety and effectiveness in these patients have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Corifact while you are pregnant. It is not known if Corifact is found in breast milk. If you are or will be breast-feeding while you use Corifact, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Corifact:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; headache; joint pain; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding or bruising at the injection site; chest, jaw, or left arm pain; confusion; decreased coordination; dizziness; fainting; fever or chills; light-headedness; numbness of an arm or leg; one-sided weakness; shortness of breath; slurred speech; stomach pain or swelling; sudden, severe headache or vomiting; symptoms of a blood clot in your leg or arm (eg, pain, tenderness, warmth, redness, swelling, lump); unusual or persistent bruising or bleeding (eg, nosebleeds); vision changes; wheezing.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Corifact:
Corifact is usually handled and stored by a health care provider. If you are using Corifact at home, store Corifact as directed by your pharmacist or health care provider. Keep Corifact out of the reach of children and away from pets.
- If you have any questions about Corifact, please talk with your doctor, pharmacist, or other health care provider.
- Corifact is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Corifact or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Corifact. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Corifact. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Corifact.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.