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Colchicine/ probenecid

Generic Name: colchicine/probenecid (KOL-chi-seen/proe-BEN-e-sid)
Brand Name: Generic only. No brands available.

Colchicine/ probenecid is used for:

Treating long-term gouty arthritis that is complicated by frequent attacks of gout. It may also be used for other conditions as determined by your doctor.

Colchicine/probenecid is a combination antigout and uricosuric agent. The uricosuric agent works by increasing the excretion of uric acid from the body. Exactly how the antigout agent works is unknown.

Do NOT use colchicine/ probenecid if:

  • you are allergic to any ingredient in colchicine/probenecid
  • you have certain blood problems or kidney stones caused by uric acid
  • you are pregnant
  • the patient is a child younger than 2 years old
  • you are taking a carbapenem antibiotic (eg, imipenem) or a salicylate (eg, aspirin)
  • you have liver or kidney problems and you are also taking certain other medicines (eg, atazanavir, boceprevir, clarithromycin, cyclosporine, darunavir, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, posaconazole, ritonavir or any medicine that contains ritonavir, saquinavir, telaprevir, telithromycin, tipranavir, troleandomycin)

Contact your doctor or health care provider right away if any of these apply to you.

Video: Treatment Options for Rheumatoid Arthritis

Doctor Ariel D. Teitel discusses several treatments that can help control the progression of the disease and help to alleviate the swelling and pain.

Before using colchicine/ probenecid:

Some medical conditions may interact with colchicine/probenecid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, sulfamethoxazole, valdecoxib, or zonisamide
  • if you have a history of liver or kidney problems, kidney stones, high levels of uric acid in the urine, stomach or bowel problems (eg, ulcer, spastic colon), heart problems, blood problems, diabetes, or glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • if you are undergoing radiation therapy or are in very poor health

Some MEDICINES MAY INTERACT with colchicine/probenecid. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin, fibrates (eg, fenofibric acid, gemfibrozil), or HMG-CoA reductase inhibitors (eg, simvastatin) because the risk of severe or fatal muscle problems may be increased
  • Aprepitant, azole antifungals (eg, fluconazole, itraconazole, ketoconazole, posaconazole), cyclosporine, diltiazem, fosaprepitant, macrolide antibiotics (eg, clarithromycin, erythromycin, troleandomycin), nefazodone, protease inhibitors (eg, boceprevir, ritonavir), ranolazine, telithromycin, or verapamil because they may increase the risk of colchicine/probenecid's side effects
  • Acidifying agents (eg, ammonium chloride), pyrazinamide, or salicylates (eg, aspirin) because they may decrease colchicine/probenecid's effectiveness
  • Acetaminophen; cephalosporins (eg, cephalexin), penicillins (eg, amoxicillin), or other beta-lactam antibiotics (eg, imipenem); ganciclovir; lorazepam; methotrexate; nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, ketoprofen); or rifampin, sulfonamides (eg, sulfamethoxazole), sulfonylureas (eg, glipizide), sympathomimetics (eg, pseudoephedrine, albuterol), theophyllines (eg, dyphylline), or zidovudine because the risk of their side effects may be increased by colchicine/probenecid

This may not be a complete list of all interactions that may occur. Ask your health care provider if colchicine/probenecid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use colchicine/ probenecid:

Use colchicine/probenecid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take colchicine/probenecid by mouth with or without food.
  • You should not start taking colchicine/probenecid if you are currently having a gout attack. Wait until the gout attack stops to begin taking colchicine/probenecid, unless directed otherwise by your doctor. If you are already taking colchicine/probenecid, you may continue to take it during a gout attack unless your doctor tells you otherwise.
  • Drinking extra fluids while you are taking colchicine/probenecid is recommended. Check with your doctor for instructions.
  • Talk with your doctor before eating grapefruit or drinking grapefruit juice while taking colchicine/probenecid.
  • If you miss a dose of colchicine/probenecid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use colchicine/probenecid.

Important safety information:

  • Colchicine/probenecid may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use colchicine/probenecid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT take more than the recommended dose without checking with your doctor.
  • Follow the dietary plan given to you by your doctor or other health care provider.
  • Tell your doctor or dentist that you take colchicine/probenecid before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Colchicine/probenecid may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Colchicine/probenecid may interfere with certain lab tests, including blood or hemoglobin urine tests and theophylline tests. Be sure your doctor and lab personnel know you are taking colchicine/probenecid.
  • Lab tests, including tests for sugar in the urine, may be performed while you use colchicine/probenecid. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use colchicine/probenecid with caution in the ELDERLY; they may be more sensitive to its effects, including muscle and nerve problems.
  • Colchicine/probenecid should not be used in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use colchicine/probenecid if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Colchicine/probenecid is found in breast milk. If you are or will be breast-feeding while you use colchicine/probenecid, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of colchicine/ probenecid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; flushing; hair loss; headache; loss of appetite; nausea; sore gums; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; dark urine; decreased or increased urination; fever, chills, or persistent sore throat; lower back, lower stomach, genital, or inner thigh pain; muscle pain, tenderness, or weakness; numbness, burning, or tingling; severe diarrhea; severe or persistent nausea or vomiting; unusual bleeding or bruising; unusual tiredness or weakness; unusually pale skin; worsening gout; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blood in the urine or decreased urination; bloody diarrhea; burning pain in the throat, stomach, or skin; muscle weakness; severe diarrhea; severe or persistent nausea, stomach pain, or vomiting.

Proper storage of colchicine/probenecid:

Store colchicine/probenecid at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep colchicine/probenecid out of the reach of children and away from pets.

General information:

  • If you have any questions about colchicine/probenecid, please talk with your doctor, pharmacist, or other health care provider.
  • Colchicine/probenecid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take colchicine/probenecid or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about colchicine/probenecid. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to colchicine/probenecid. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using colchicine/probenecid.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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