Clomiphene

Pronunciation

Generic Name: clomiphene (KLOE-mi-feen)
Brand Name: Clomid and Serophene

Clomiphene is used for:

Treating female infertility in certain women. It may also be used for other conditions as determined by your doctor.

Clomiphene is an ovulatory stimulant. It works by increasing certain hormones, which causes your ovaries to release mature eggs.

Do NOT use clomiphene if:

  • you are allergic to any ingredient in clomiphene
  • you are pregnant
  • you have abnormal vaginal bleeding
  • you have ovarian cysts (small growths on the ovaries) or enlargement not caused by polycystic ovarian syndrome (PCOS)
  • you have or have ever had liver problems
  • you have uncontrolled thyroid or adrenal gland problems, or a brain lesion (eg, pituitary gland tumor)

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: View Frightful (But Dead Serious) Drug Side Effects

Before using clomiphene:

Some medical conditions may interact with clomiphene. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have depression, endometriosis, PCOS, ovarian cancer, or uterine fibroids
  • if you have thyroid problems, adrenal gland problems, or high blood prolactin levels
  • if you have a history of blood clots (eg, in the legs, lungs, or other parts of the body) or you have an increased risk for blood clots

Some MEDICINES MAY INTERACT with clomiphene. However, no specific interactions with clomiphene are known at this time.

Ask your health care provider if clomiphene may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use clomiphene:

Use clomiphene as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take clomiphene by mouth with or without food.
  • Properly timed sexual intercourse is important for good results. Ovulation usually occurs 5 to 10 days after a course of clomiphene.
  • If you do not ovulate or become pregnant after 3 courses of treatment, further treatment is not recommended. Long-term use of clomiphene is not recommended.
  • If you miss a dose of clomiphene, contact your doctor right away.

Ask your health care provider any questions you may have about how to use clomiphene.

Important safety information:

  • Clomiphene may cause dizziness or vision problems. These effects may be worse if you take it with alcohol or certain medicines. Use clomiphene with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT change your dose or take for longer than prescribed without checking with your doctor.
  • Clomiphene may cause certain vision problems (eg, blurred vision, spots or flashes). If these problems occur, they often appear or become worse in the presence of brightly lit surroundings. The risk of these symptoms may be increased in patients who take higher doses or who take clomiphene for a long period of time. These vision problems usually go away. However, some patients have reported prolonged vision problems, even after stopping clomiphene. It is also possible that the vision problems may not go away. Discuss any questions or concerns with your doctor. Tell your doctor right away if you develop any vision changes or problems.
  • Ovarian Hyperstimulation Syndrome (OHSS) is a severe side effect that may occur in some women who use clomiphene. Contact your doctor right away if you develop severe stomach pain or bloating; nausea, vomiting, or diarrhea; sudden, unexplained weight gain; shortness of breath; or decreased urination. Discuss any questions or concerns with your doctor.
  • Clomiphene may increase your chance of multiple births (eg, twins). It may also increase the risk of tubal pregnancy, a possibly life-threatening condition. Talk with your doctor to discuss your chances of multiple births or tubal pregnancy. Discuss any questions or concerns with your doctor.
  • Lab and medical tests, including pelvic exams, pregnancy tests, and hormone levels, may be performed while you use clomiphene. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Clomiphene should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use clomiphene if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if clomiphene is found in breast milk. If you are or will be breast-feeding while you use clomiphene, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of clomiphene:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breast tenderness or discomfort; flushing; hot flashes.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal vaginal bleeding; calf or leg pain, redness, swelling, or tenderness; chest pain; coughing up blood; mental or mood changes (eg, depression); severe or persistent headache; severe or persistent backache; severe or persistent indigestion, bloating, gas, or stomach pain; symptoms of OHSS (eg, nausea, vomiting, or diarrhea; sudden, unexplained weight gain; shortness of breath; decreased urination); vision changes (eg, blurred vision, flashes or spots).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include flushing; nausea; stomach pain; vision changes (eg, blurred vision, flashes or spots); vomiting.

Proper storage of clomiphene:

Store clomiphene at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep clomiphene out of the reach of children and away from pets.

General information:

  • If you have any questions about clomiphene, please talk with your doctor, pharmacist, or other health care provider.
  • Clomiphene is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take clomiphene or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about clomiphene. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to clomiphene. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using clomiphene.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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