Clolar

Generic Name: clofarabine (kloe-FAR-a-been)
Brand Name: Clolar

Clolar is used for:

Treating certain types of leukemia in children and adolescents who have had at least 2 previous treatment regimens of medicine.

Clolar is a form of antimetabolite chemotherapy. It works by blocking cancer cell growth, which results in death of the cancer cell.

Do NOT use Clolar if:

  • you are allergic to any ingredient in Clolar
  • you are taking medicines that may affect the kidney, such as aminoglycoside antibiotics (eg, gentamicin), amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), tacrolimus, and vancomycin. Ask your doctor if you are unsure whether any of your medicines might affect your kidneys
  • you are taking medicines that may affect the liver (such as acetaminophen), certain medicines for HIV infection, isoniazid, ketoconazole, and methotrexate. Ask your doctor if you are unsure whether any of your medicines might affect your liver
  • you have taken or will be taking palifermin within 24 hours before or after using Clolar

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Clolar:

Some medical conditions may interact with Clolar. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have high or low blood pressure, kidney problems, liver problems, or heart problems
  • if you have an infection, certain blood problems (eg, low white blood cell levels, low platelet levels), or bone marrow problems
  • if you have previously had a hematopoietic stem cell transplant (HSCT)

Some MEDICINES MAY INTERACT with Clolar. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Medicines that may affect your heart function or blood pressure because the side effects of Clolar, such as low blood pressure or heart effects, may be increased. Ask your doctor if you are unsure whether any of your medicines might affect your heart function or blood pressure
  • Medicines that affect your kidneys or liver because the risk of Clolar's side effects may be increased
  • Palifermin because if mouth sores develop, they may be more severe or last longer

This may not be a complete list of all interactions that may occur. Ask your health care provider if Clolar may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Clolar:

Use Clolar as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Clolar is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Clolar at home, a health care provider will teach you how to use it. Be sure you understand how to use Clolar. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Clolar if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Do not administer any other medicines through the same intravenous line as Clolar.
  • If Clolar accidentally spills on your skin, wash it off immediately with soap and water.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Clolar, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Clolar.

Important safety information:

  • Clolar may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use Clolar with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
  • Notify your doctor immediately if you experience symptoms of dehydration such as dry mouth; decreased urination; unusual thirst; weakness; unusual drowsiness or lethargy; muscle pain, cramps, or weakness; severe dizziness or fainting; or rapid heartbeat.
  • Clolar may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Clolar may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection such as fever, sore throat, rash, or chills.
  • A serious and possibly fatal condition called tumor lysis syndrome has been rarely reported in certain patients taking Clolar. Contact your doctor right away if you develop symptoms such as fast or irregular heartbeat; fainting; decreased urination; muscle weakness or cramps; nausea, vomiting, diarrhea, or loss of appetite; or sluggishness. Discuss any questions or concerns with your doctor.
  • Proper dental care is important while you are taking Clolar. Brush and floss your teeth and visit the dentist regularly.
  • Do not receive a live vaccine (eg, measles, mumps) while you are taking Clolar. Talk with your doctor before you receive any vaccine.
  • Tell your doctor or dentist that you take Clolar before you receive any medical or dental care, emergency care, or surgery.
  • Women who may become pregnant must use an effective form of birth control while they take Clolar. If you have questions about effective birth control, talk with your doctor.
  • Men who use Clolar should always use a condom when having sex with a woman who may become pregnant. Do this for as long as you use Clolar.
  • Lab tests including blood counts, blood pressure, lung function, liver function, kidney function, and blood uric acid levels may be performed while you use Clolar. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Safety and effectiveness of Clolar have not been established in ADULTS.
  • PREGNANCY AND BREAST-FEEDING: Clolar may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clolar while you are pregnant. It is not known if Clolar is found in breast milk. Do not breast-feed while taking Clolar.

Possible side effects of Clolar:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; diarrhea; drowsiness; flushing; gum bleeding; headache; joint or muscle pain or weakness; loss of appetite; mild stomach pain; mild tiredness or weakness; minor pain, swelling, or redness at the injection site; nausea; swelling or soreness of the mouth; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering or severe swelling or pain at the injection site; blood in the urine; chest pain; cloudy urine; decreased urination; fainting; fast breathing; fast or irregular heartbeat; fever, chills, or sore throat; mental or mood changes; nosebleed; persistent cough; red, swollen, blistered, or peeling skin; severe or persistent dizziness, light-headedness, or headache; severe or persistent tiredness or weakness; severe or persistent vomiting or diarrhea; shortness of breath; small red spots under the skin; swelling of arms or legs; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, severe or unusual stomach pain, yellowing of the skin or eyes); tingling, pain, redness, or swelling of the palms of the hands or soles of the feet; unusual bleeding or easy bruising; unusually pale skin; white patches in the mouth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include rash; vomiting.

Proper storage of Clolar:

Store undiluted vials of Clolar at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. After diluting, Clolar may be stored at room temperature and must be used within 24 hours. Keep Clolar out of the reach of children and away from pets.

General information:

  • If you have any questions about Clolar, please talk with your doctor, pharmacist, or other health care provider.
  • Clolar is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Clolar or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Clolar. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Clolar. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Clolar.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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