Generic Name: c1 esterase inhibitor (human) (C1 ES-ter-ase in-HIB-i-ter)
Brand Name: Cinryze
Cinryze is used for:
Preventing angioedema attacks in teenagers and adults with hereditary angioedema (HAE).
Cinryze is a C1 esterase inhibitor (human). It works by helping to control inflammation and parts of the immune system. This helps to prevent the swelling and/or painful attacks that occur with HAE.
Do NOT use Cinryze if:
- you are allergic to any ingredient in Cinryze
Contact your doctor or health care provider right away if any of these apply to you.
Before using Cinryze:
Some medical conditions may interact with Cinryze. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of blood clotting problems, such as blood clots in your veins or lungs (eg, deep vein thrombosis, pulmonary embolism)
Some MEDICINES MAY INTERACT with Cinryze. However, no specific interactions with Cinryze are known at this time.
Ask your health care provider if Cinryze may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Cinryze:
Use Cinryze as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Cinryze. Talk to your pharmacist if you have questions about this information.
- Cinryze may be given as an injection at your doctor's office, hospital, or clinic. If you will be using Cinryze at home, a health care provider will teach you how to use it. Be sure you understand how to use Cinryze. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- After mixing, Cinryze should be colorless to slightly blue. Do not use Cinryze if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Cinryze must be mixed before use. Use within 3 hours after mixing.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Cinryze, contact your doctor right away.
Ask your health care provider any questions you may have about how to use Cinryze.
Important safety information:
- Cinryze may contain albumin, which comes from human blood. There is a very rare risk of getting a viral disease or a central nervous system disease called Creutzfeldt-Jakob disease from products with albumin. No cases of these problems have been found in patients who have used Cinryze.
- The risk of blood clots (eg, in your veins or lungs) may be increased with high doses of Cinryze. Tell your doctor if you have a history of blood clotting problems. Contact your doctor right away if you develop symptoms of a blood clot (eg, changes in consciousness, speech, or vision; one-sided weakness or loss of muscle control; severe or persistent headache; chest pain; shortness of breath; pain, numbness, or swelling in your arms or legs) while you are using Cinryze. Talk with your doctor for more information.
- Cinryze should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: It is not known if Cinryze can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cinryze while you are pregnant. It is not known if Cinryze is found in breast milk. If you are or will be breast-feeding while you use Cinryze, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Cinryze:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Headache; stuffy or runny nose.
Severe allergic reactions (rash; hives; itching; difficulty breathing or shortness of breath; tightness in the chest; fast heartbeat; severe dizziness or lightheadedness; fainting; swelling of the mouth, face, lips, or tongue; blue lips or gums; wheezing); symptoms of infection (eg, fever, sore throat, cough).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include changes in consciousness, speech, or vision; chest pain; one-sided weakness or loss of muscle control; pain, numbness, or swelling in your arms or legs; severe or persistent headache; shortness of breath.Proper storage of Cinryze:
Store Cinryze in the refrigerator or at room temperature, between 36 and 77 degrees F (2 and 25 degrees C). Do not freeze. Store in original packaging until just before use. Do not use Cinryze if the expiration date has passed. After mixing, you may store Cinryze at room temperature for up to 3 hours. If you do not use it within 3 hours after mixing, throw it away. Keep Cinryze out of the reach of children and away from pets.
- If you have any questions about Cinryze, please talk with your doctor, pharmacist, or other health care provider.
- Cinryze is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Cinryze or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Cinryze. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Cinryze. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Cinryze.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.