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Chlorpheniramine/ phenylephrine/ methscopolamine sustained-release and long-acting tablets

Generic Name: chlorpheniramine/phenylephrine/methscopolamine (KLOR-fen-IR-a-meen/FEN-il-EF-rin/METH-skoe-POL-a-meen)
Brand Name: Examples include Aerohist Plus and Dallergy

Chlorpheniramine/ phenylephrine/ methscopolamine sustained-release and long-acting tablets is used for:

Relieving congestion, sneezing, runny nose, and itchy, watery eyes due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets is an antihistamine, decongestant, and anticholinergic combination. It works by blocking histamine, a substance in the body that causes sneezing, runny nose, and watery eyes. It also relieves nasal congestion by shrinking the nasal mucous membranes, which promotes nasal drainage, and dries the chest by decreasing lung secretions.

Do NOT use chlorpheniramine/ phenylephrine/ methscopolamine sustained-release and long-acting tablets if:

  • you are allergic to any ingredient in chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets
  • you are pregnant or breast-feeding
  • you take sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
  • you have a history of narrow-angle glaucoma, blockage in the stomach or intestines, peptic ulcer disease, intestinal or bowel problems, difficulty urinating, inflammation of the esophagus from reflux disease, difficulty swallowing, or uncontrolled bleeding
  • you have severe heart disease or severe high blood pressure

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: OTC Medication Use In Pregnancy: Wise or Worrisome?

Before using chlorpheniramine/ phenylephrine/ methscopolamine sustained-release and long-acting tablets:

Some medical conditions may interact with chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are taking or have taken medicine for high blood pressure or depression in the last 14 days
  • if you have diabetes, an enlarged prostate, a history of bladder or kidney problems, high blood pressure, diarrhea, asthma, nerve problems, heart problems, blood clots, a hiatal hernia, an adrenal gland tumor, glaucoma or increased pressure in the eye, breathing problems during sleep, myasthenia gravis (muscle weakness), lung problems, liver problems, Down syndrome, blood vessel problems, or an overactive thyroid

Some MEDICINES MAY INTERACT with chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Alpha-blockers (eg, guanethidine, methyldopa, prazosin), beta-blockers (eg, atenolol), diuretics (eg, furosemide, hydrochlorothiazide), furazolidone, or MAOIs (eg, phenelzine) because the risk of high or low blood pressure may be increased
  • Alkalizers (eg, calcium or magnesium antacids), anticholinergics (eg, atropine, benztropine, dicyclomine), carbonic anhydrase inhibitors (eg, acetazolamide), ergotamine, sodium bicarbonate, or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets's side effects
  • Bromocriptine, catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), certain stimulants (eg, doxapram, pseudoephedrine), cocaine, digoxin, droxidopa, potassium chloride, or sodium oxybate ( GHB) because the risk of their side effects may be increased by chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use chlorpheniramine/ phenylephrine/ methscopolamine sustained-release and long-acting tablets:

Use chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Swallow chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets whole. Do not break, crush, or chew before swallowing. Some brands of chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets may be broken in half before taking. If you have difficulty swallowing the whole tablet, ask your pharmacist if your brand of medicine may be broken in half.
  • Do not take chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets at the same time as antacids, certain medicines for diarrhea (eg, attapulgite, bismuth, kaolin, pectin), or ketoconazole. Take these medicines 2 or 3 hours before or after you take chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets.
  • If you miss a dose of chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets.

Important safety information:

  • Chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If your symptoms do not get better within 7 days or if you develop a high fever or persistent headache, check with your doctor.
  • Chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets.
  • Chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets for a few days before the tests.
  • Chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets may cause dry mouth. To relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute.
  • Chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
  • Chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets may reduce sweating. Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Do not take diet or appetite control medicines while you are taking chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets without checking with your doctor.
  • If you have trouble sleeping, ask your doctor or pharmacist about the best time of the day to take chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets.
  • Diabetes patients - Chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Use chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets with caution in the ELDERLY; they may be more sensitive to its effects.
  • Chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets while you are pregnant. Do not use chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets during labor or delivery because it may cause harm to the fetus. Chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets is found in breast milk. Do not breast-feed while taking chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets.

Possible side effects of chlorpheniramine/ phenylephrine/ methscopolamine sustained-release and long-acting tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; clumsiness; constipation; dizziness; drowsiness; dry mouth, nose, or throat; excitability or irritability (especially in children); flushing; giddiness; headache; lack of energy; nausea; nervousness; tearing; trouble sleeping; unusual tiredness or weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; difficulty swallowing; fast or irregular heartbeat; hallucinations; mental or mood changes; pounding in the chest; sore throat with fever; trouble urinating; unusual bleeding or bruising; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; hot or cool skin; irregular heartbeat; irritability, anxiety, or panic; large pupils; numbness or tingling in the arms or legs; seizures; slowed or shallow breathing; vomiting.

Proper storage of chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets:

Store chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using chlorpheniramine/phenylephrine/methscopolamine sustained-release and long-acting tablets.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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