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Chlorpheniramine/ methscopolamine/ phenylephrine suspension

Generic Name: chlorpheniramine/methscopolamine/phenylephrine (klor-fen-EER-a-meen/meth-skoe-POL-a-meen/fen-ill-EF-rin)
Brand Name: Examples include AH-Chew and Dura Tan PE

Chlorpheniramine/ methscopolamine/ phenylephrine suspension is used for:

Relieving congestion, sneezing, runny nose, and itchy, watery eyes due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Chlorpheniramine/methscopolamine/phenylephrine suspension is an antihistamine, decongestant, and anticholinergic combination. It works by blocking histamine, a substance in the body that causes sneezing, runny nose, and watery eyes. It also relieves nasal congestion by shrinking the nasal mucous membranes, which promotes nasal drainage, and dries the chest by decreasing lung secretions.

Do NOT use chlorpheniramine/ methscopolamine/ phenylephrine suspension if:

  • you are allergic to any ingredient in chlorpheniramine/methscopolamine/phenylephrine suspension
  • you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) in the last 14 days
  • you have narrow-angle glaucoma; a blockage of the bladder, stomach, or intestines; peptic ulcer disease; severe bowel problems (eg, ulcerative colitis); inflammation of the esophagus from reflux disease; difficulty swallowing; myasthenia gravis (muscle weakness); or uncontrolled bleeding
  • you have severe heart disease, severe high blood pressure, severe heart blood vessel problems, a rapid heartbeat, or you are unable to urinate
  • you are having an asthma attack

Contact your doctor or health care provider right away if any of these apply to you.

Before using chlorpheniramine/ methscopolamine/ phenylephrine suspension:

Some medical conditions may interact with chlorpheniramine/methscopolamine/phenylephrine suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of diabetes, an enlarged prostate, bladder or kidney problems, high blood pressure, asthma, lung problems (eg, emphysema), nerve problems, heart problems (eg, ischemic heart disease, irregular heartbeat), blood vessel problems, blood clots, stroke, a hiatal hernia, an adrenal gland tumor, increased pressure in the eye, glaucoma, or risk factors for glaucoma, breathing problems during sleep, seizures, trouble urinating, or an overactive thyroid
  • if you have diarrhea

Some MEDICINES MAY INTERACT with chlorpheniramine/methscopolamine/phenylephrine suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Sodium oxybate (GHB) because the risk of severe drowsiness or coma may be increased
  • Furazolidone or MAOIs (eg, phenelzine) because severe high blood pressure, fast or irregular heartbeat, or seizures may occur
  • Alpha-blockers (eg, prazosin), anesthetics (eg, chloroform, lidocaine), anticholinergics (eg, atropine, benztropine, dicyclomine), beta-blockers (eg, propranolol), carbonic anhydrase inhibitors (eg, acetazolamide), diuretics (eg, furosemide, hydrochlorothiazide), ergotamine, tricyclic antidepressants (eg, amitriptyline), or urinary alkalinizers (eg, sodium bicarbonate) because they may increase the risk of chlorpheniramine/methscopolamine/phenylephrine suspension's side effects
  • Bromocriptine, catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), certain stimulants (eg, doxapram, pseudoephedrine), cocaine, digoxin, droxidopa, or potassium chloride because the risk of their side effects may be increased by chlorpheniramine/methscopolamine/phenylephrine suspension
  • Clonidine, guanethidine, guanfacine, mecamylamine, methyldopa, and reserpine because their effectiveness may be decreased by chlorpheniramine/methscopolamine/phenylephrine suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if chlorpheniramine/methscopolamine/phenylephrine suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use chlorpheniramine/ methscopolamine/ phenylephrine suspension:

Use chlorpheniramine/methscopolamine/phenylephrine suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take chlorpheniramine/methscopolamine/phenylephrine suspension by mouth with or without food.
  • Shake well before each use.
  • Do not take chlorpheniramine/methscopolamine/phenylephrine suspension at the same time as antacids, certain medicines for diarrhea (eg, kaolin, pectin, attapulgite, bismuth), or ketoconazole. Take these medicines 2 or 3 hours before or after you take chlorpheniramine/methscopolamine/phenylephrine suspension.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of chlorpheniramine/methscopolamine/phenylephrine suspension and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use chlorpheniramine/methscopolamine/phenylephrine suspension.

Important safety information:

  • Chlorpheniramine/methscopolamine/phenylephrine suspension may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use chlorpheniramine/methscopolamine/phenylephrine suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using chlorpheniramine/methscopolamine/phenylephrine suspension; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • If your symptoms do not get better within 7 days or if you develop a high fever or persistent headache, check with your doctor.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Chlorpheniramine/methscopolamine/phenylephrine suspension may cause dry mouth. To relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute.
  • Chlorpheniramine/methscopolamine/phenylephrine suspension may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
  • Chlorpheniramine/methscopolamine/phenylephrine suspension may reduce sweating. Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Do not take diet or appetite control medicines while you are taking chlorpheniramine/methscopolamine/phenylephrine suspension without checking with your doctor.
  • Chlorpheniramine/methscopolamine/phenylephrine suspension has phenylephrine in it. Before you start any new medicine, check the label to see if it has phenylephrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • If you have trouble sleeping, ask your doctor or pharmacist about the best time of the day to take chlorpheniramine/methscopolamine/phenylephrine suspension.
  • Tell your doctor or dentist that you take chlorpheniramine/methscopolamine/phenylephrine suspension before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Chlorpheniramine/methscopolamine/phenylephrine suspension may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Chlorpheniramine/methscopolamine/phenylephrine suspension may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking chlorpheniramine/methscopolamine/phenylephrine suspension.
  • Use chlorpheniramine/methscopolamine/phenylephrine suspension with caution in the ELDERLY; they may be more sensitive to its effects.
  • Chlorpheniramine/methscopolamine/phenylephrine suspension should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if chlorpheniramine/methscopolamine/phenylephrine suspension can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using chlorpheniramine/methscopolamine/phenylephrine suspension while you are pregnant. It is not known if chlorpheniramine/methscopolamine/phenylephrine suspension is found in breast milk. Do not breast-feed while taking chlorpheniramine/methscopolamine/phenylephrine suspension.

Possible side effects of chlorpheniramine/ methscopolamine/ phenylephrine suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth, nose, or throat; excitability or irritability (especially in children); flushing; headache; nausea; nervousness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; clumsiness; difficulty swallowing; fast or irregular heartbeat; hallucinations; mental or mood changes; seizures; tremor; trouble sleeping; trouble urinating; unusual bleeding or bruising; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; hallucinations; hot or cool skin; irregular heartbeat; irritability, anxiety, or panic; large pupils; numbness or tingling in the arms or legs; seizures; slowed or shallow breathing; vomiting.

Proper storage of chlorpheniramine/methscopolamine/phenylephrine suspension:

Store chlorpheniramine/methscopolamine/phenylephrine suspension at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep chlorpheniramine/methscopolamine/phenylephrine suspension out of the reach of children and away from pets.

General information:

  • If you have any questions about chlorpheniramine/methscopolamine/phenylephrine suspension, please talk with your doctor, pharmacist, or other health care provider.
  • Chlorpheniramine/methscopolamine/phenylephrine suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about chlorpheniramine/methscopolamine/phenylephrine suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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