Chlorpheniramine/ hydrocodone extended release capsules

Generic Name: chlorpheniramine/hydrocodone (KLOR-fen-IR-a-meen/hye-droe-KOE-done)
Brand Name: TussiCaps

Chlorpheniramine/ hydrocodone extended release capsules is used for:

Treating symptoms of the common cold, hay fever, and other upper respiratory allergies such as cough, runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes. Chlorpheniramine/hydrocodone extended release capsules may also be used for other conditions as determined by your doctor.

Chlorpheniramine/hydrocodone extended release capsules is a narcotic antitussive (cough suppressant) and antihistamine combination. The antitussive (codeine) works by suppressing the cough center in the brain. The antihistamine (promethazine) works by blocking the action of histamine, which reduces the symptoms of an allergic reaction such as itch, watery eyes and runny nose.

Do NOT use chlorpheniramine/ hydrocodone extended release capsules if:

  • you are allergic to any ingredient in chlorpheniramine/hydrocodone extended release capsules or to any other codeine-related medicine (eg, morphine)
  • you have diarrhea caused by food poisoning, antibiotic use, or a bacterial infection (from eating or drinking contaminated food or water)
  • you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: OTC Medication Use In Pregnancy: Wise or Worrisome?

Before using chlorpheniramine/ hydrocodone extended release capsules:

Some medical conditions may interact with chlorpheniramine/hydrocodone extended release capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have or have ever had alcoholism, substance abuse, or narcotic dependence, or if you drink more than 3 alcoholic drinks per day
  • if you have a history of mental or mood problems or suicidal thoughts or attempts
  • if you have increased pressure in the eyes or glaucoma, or if you are are at risk for glaucoma
  • if you have a head injury, increased pressure in the head, a brain injury or tumor, epilepsy or seizures, or Reye syndrome
  • if you are having an asthma attack or have lung or breathing problems, including shortness of breath or sleep apnea
  • if you have a stomach or intestinal problem; chronic inflammation and ulceration of the bowel; chronic constipation; difficulty urinating; enlargement of the prostate gland; heart problems, including heart failure; low blood pressure; liver problems; kidney problems; Parkinson disease; the blood disease porphyria; stomach, intestinal, or urinary blockage; or thyroid problems
  • if you have recently had surgery

Some MEDICINES MAY INTERACT with chlorpheniramine/hydrocodone extended release capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, scopolamine) because an intestinal problem (paralytic ileus) may occur
  • Barbiturate anesthetics (eg, thiopental), cimetidine, ketorolac, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), naltrexone, sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of chlorpheniramine/hydrocodone extended release capsules's side effects, including dangerous sleepiness and a decrease in the ability to breathe
  • Rifampin or risperidone because they may decrease chlorpheniramine/hydrocodone extended release capsules's effectiveness
  • Hydantoins (eg, phenytoin) because the risk of their side effects may be increased by chlorpheniramine/hydrocodone extended release capsules
  • Mexiletine because its effectiveness may be decreased by chlorpheniramine/hydrocodone extended release capsules
  • Naltrexone because chlorpheniramine/hydrocodone extended release capsules's effectiveness will be decreased and withdrawal symptoms may occur in patients who have become physically dependent on opioids. You must not take naltrexone until you have stopped taking chlorpheniramine/hydrocodone extended release capsules for 7 to 10 days and after a naloxone challenge test is negative

This may not be a complete list of all interactions that may occur. Ask your health care provider if chlorpheniramine/hydrocodone extended release capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use chlorpheniramine/ hydrocodone extended release capsules:

Use chlorpheniramine/hydrocodone extended release capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take chlorpheniramine/hydrocodone extended release capsules by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Swallow chlorpheniramine/hydrocodone extended release capsules whole. Do not, break, crush, chew, open, or dissolve before swallowing.
  • If you miss a dose of chlorpheniramine/hydrocodone extended release capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Do not take more than 2 capsules in 24 hours.

Ask your health care provider any questions you may have about how to use chlorpheniramine/hydrocodone extended release capsules.

Important safety information:

  • Chlorpheniramine/hydrocodone extended release capsules may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use chlorpheniramine/hydrocodone extended release capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol while you are using chlorpheniramine/hydrocodone extended release capsules.
  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using chlorpheniramine/hydrocodone extended release capsules; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If your symptoms do not get better within 7 days or if you develop a high fever or persistent headache, check with your doctor.
  • Tell your doctor or dentist that you take chlorpheniramine/hydrocodone extended release capsules before you receive any medical or dental care, emergency care, or surgery.
  • Use chlorpheniramine/hydrocodone extended release capsules with caution in the ELDERLY; they may be more sensitive to its effects, especially possible breathing problems and drowsiness.
  • Chlorpheniramine/hydrocodone extended release capsules should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Chlorpheniramine/hydrocodone extended release capsules has been shown to cause harm to the fetus, especially during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using chlorpheniramine/hydrocodone extended release capsules while you are pregnant. Chlorpheniramine/hydrocodone extended release capsules is found in breast milk. Do not breast-feed while taking chlorpheniramine/hydrocodone extended release capsules.

When used for long periods of time or at high doses, chlorpheniramine/hydrocodone extended release capsules may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if chlorpheniramine/hydrocodone extended release capsules stops working well. Do not take more than prescribed.

Some people who use chlorpheniramine/hydrocodone extended release capsules for a long time without a break may develop a physical need to continue taking it. This is known as physical DEPENDENCE. The early sign of addiction is medicine ineffectiveness. Dependence is not an issue in terminal illness in which pain relief is more important. If using chlorpheniramine/hydrocodone extended release capsules for an extended period of time, do not suddenly stop taking chlorpheniramine/hydrocodone extended release capsules without your doctor's approval. If you suddenly stop taking chlorpheniramine/hydrocodone extended release capsules, you may experience WITHDRAWAL symptoms, including anxiety; diarrhea; fever; runny nose or sneezing; goose bumps and abnormal skin sensations; nausea and vomiting; pain; rigid muscles; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping. Contact your doctor if you notice any of these symptoms after stopping this medication.

Possible side effects of chlorpheniramine/ hydrocodone extended release capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth, throat, or nose; excitement; nausea; stomach upset; thickening or mucus in nose or throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; flushing or redness of face; mental or mood changes; rapid or pounding heartbeat; severe drowsiness or dizziness; shortness of breath.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; coma; confusion; deep sleep or loss of consciousness; difficulty breathing; diminished mental alertness; hallucinations; hot or cold skin; large and unchanging pupils; sedation; seizures; shaking; sleeplessness; slow heartbeat; slowed breathing.

Proper storage of chlorpheniramine/hydrocodone extended release capsules:

Store chlorpheniramine/hydrocodone extended release capsules at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep chlorpheniramine/hydrocodone extended release capsules out of the reach of children and away from pets.

General information:

  • If you have any questions about chlorpheniramine/hydrocodone extended release capsules, please talk with your doctor, pharmacist, or other health care provider.
  • Chlorpheniramine/hydrocodone extended release capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take chlorpheniramine/hydrocodone extended release capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about chlorpheniramine/hydrocodone extended release capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to chlorpheniramine/hydrocodone extended release capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using chlorpheniramine/hydrocodone extended release capsules.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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