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Chlorpheniramine/ guaifenesin/ pseudoephedrine

Generic Name: chlorpheniramine/guaifenesin/pseudoephedrine (klor-fen-EER-a-meen/gwye-FEN-e-sin/sue-do-eh-FED-rin)
Brand Name: Lemohist Plus

Chlorpheniramine/ guaifenesin/ pseudoephedrine is used for:

Relieving symptoms of sinus congestion, runny nose, sneezing, and throat and airway irritation due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Chlorpheniramine/guaifenesin/pseudoephedrine is a decongestant, antihistamine, and expectorant combination. It works by constricting blood vessels and reducing swelling in the nasal passages, making it easier to breathe. The antihistamine works by blocking the action of histamine, which helps reduce symptoms, such as watery eyes and sneezing, while the expectorant loosens mucus and lung secretions in the chest and makes coughs more productive.

Do NOT use chlorpheniramine/ guaifenesin/ pseudoephedrine if:

  • you are allergic to any ingredient in chlorpheniramine/guaifenesin/pseudoephedrine
  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
  • you are unable to urinate or are having an asthma attack
  • you take sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using chlorpheniramine/ guaifenesin/ pseudoephedrine:

Some medical conditions may interact with chlorpheniramine/guaifenesin/pseudoephedrine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a fast, slow, or irregular heartbeat
  • if you have a history of adrenal gland problems (eg, adrenal gland tumor); heart problems; high blood pressure; diabetes; blood vessel problems; stroke; glaucoma; a blockage of your bladder, stomach, or intestines; ulcers; trouble urinating; an enlarged prostate or other prostate problems; seizures; or an overactive thyroid

Some MEDICINES MAY INTERACT with chlorpheniramine/guaifenesin/pseudoephedrine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAO inhibitors (eg, phenelzine ), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because the side effects of chlorpheniramine/guaifenesin/pseudoephedrine may be increased
  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Bromocriptine or hydantoins (eg, phenytoin) because side effects may be increased by chlorpheniramine/guaifenesin/pseudoephedrine
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by chlorpheniramine/guaifenesin/pseudoephedrine

This may not be a complete list of all interactions that may occur. Ask your health care provider if chlorpheniramine/guaifenesin/pseudoephedrine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use chlorpheniramine/ guaifenesin/ pseudoephedrine:

Use chlorpheniramine/guaifenesin/pseudoephedrine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Chlorpheniramine/guaifenesin/pseudoephedrine may be taken with or without food.
  • If you miss a dose of chlorpheniramine/guaifenesin/pseudoephedrine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use chlorpheniramine/guaifenesin/pseudoephedrine.

Important safety information:

  • Chlorpheniramine/guaifenesin/pseudoephedrine may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to chlorpheniramine/guaifenesin/pseudoephedrine. Using chlorpheniramine/guaifenesin/pseudoephedrine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Do not take diet or appetite control medicines while you are taking chlorpheniramine/guaifenesin/pseudoephedrine without checking with your doctor.
  • Chlorpheniramine/guaifenesin/pseudoephedrine contains chlorpheniramine and pseudoephedrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains chlorpheniramine or pseudoephedrine. If it does or if you are uncertain, contact your doctor or pharmacist.
  • Do NOT exceed the recommended dose or take chlorpheniramine/guaifenesin/pseudoephedrine for longer than prescribed without checking with your doctor.
  • If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.
  • Chlorpheniramine/guaifenesin/pseudoephedrine may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to chlorpheniramine/guaifenesin/pseudoephedrine. Use a sunscreen or wear protective clothing if you must be outside for a prolonged period.
  • If you are scheduled for allergy skin testing, do not take chlorpheniramine/guaifenesin/pseudoephedrine for several days before the test because it may decrease your response to the skin tests.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using chlorpheniramine/guaifenesin/pseudoephedrine.
  • Use chlorpheniramine/guaifenesin/pseudoephedrine with caution in the ELDERLY because they may be more sensitive to its effects.
  • Caution is advised when using chlorpheniramine/guaifenesin/pseudoephedrine in CHILDREN because they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking chlorpheniramine/guaifenesin/pseudoephedrine, discuss with your doctor the benefits and risks of using chlorpheniramine/guaifenesin/pseudoephedrine during pregnancy. It is unknown if chlorpheniramine/guaifenesin/pseudoephedrine is excreted in breast milk. Do not breast-feed while taking chlorpheniramine/guaifenesin/pseudoephedrine.

Possible side effects of chlorpheniramine/ guaifenesin/ pseudoephedrine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; trouble sleeping; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org ), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of chlorpheniramine/guaifenesin/pseudoephedrine:

Store chlorpheniramine/guaifenesin/pseudoephedrine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep chlorpheniramine/guaifenesin/pseudoephedrine out of the reach of children and away from pets.

General information:

  • If you have any questions about chlorpheniramine/guaifenesin/pseudoephedrine, please talk with your doctor, pharmacist, or other health care provider.
  • Chlorpheniramine/guaifenesin/pseudoephedrine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take chlorpheniramine/guaifenesin/pseudoephedrine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about chlorpheniramine/guaifenesin/pseudoephedrine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to chlorpheniramine/guaifenesin/pseudoephedrine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using chlorpheniramine/guaifenesin/pseudoephedrine.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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