Generic Name: chlordiazepoxide (klor-DYE-aze-ee-POX-ide)
Brand Name: Librium
Chlordiazepoxide injection is used for:
Treating anxiety disorders and withdrawal symptoms due to alcoholism. It is also used to reduce fear and anxiety (nervous tension) before undergoing surgery. It may be used for other conditions as determined by your doctor.
Chlordiazepoxide injection is a benzodiazepine. It works by slowing down the movement of chemicals in the brain. This results in a reduction in nervous tension (anxiety) and muscle spasm, and also causes sedation.
Do NOT use chlordiazepoxide injection if:
- you are allergic to any ingredient in chlordiazepoxide injection
- you have acute narrow-angle glaucoma, severe liver disease, or a mental state where contact with reality is lost (psychosis)
- you are taking sodium oxybate (GHB)
Contact your doctor or health care provider right away if any of these apply to you.
Before using chlordiazepoxide injection:
Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have glaucoma or a predisposition for glaucoma, liver problems, lung problems or chronic obstructive pulmonary disease (COPD), muscle problems, depression, suicidal tendencies, the blood disorder porphyria, or a history of drug abuse or dependence
Some MEDICINES MAY INTERACT with chlordiazepoxide injection. Tell your health care provider if you are taking any of the following medicines.
- Rifampin because the effectiveness of chlordiazepoxide injection may be decreased
- Azole antifungals (eg, ketoconazole), clozapine, disulfiram, nefazodone, omeprazole, sodium oxybate (GHB), or valproic acid because side effects such as increased sedation may occur
- Clozapine, hydantoins (eg, phenytoin), or sodium oxybate (GHB) because the actions and side effects of these medicines may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if chlordiazepoxide injection may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use chlordiazepoxide injection:
Use chlordiazepoxide injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Chlordiazepoxide injection is usually administered as an injection at your doctor's office, hospital, or clinic.
- If you are using chlordiazepoxide injection at home, carefully follow the injection procedures taught to you by your health care provider.
- If the medicine contains particles or is discolored, or if the vial/container is cracked or damaged in any way, do not use it.
- Try to stay in bed for 3 hours after taking chlordiazepoxide injection.
- Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
- If you miss a dose of chlordiazepoxide injection and you are using it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use chlordiazepoxide injection.
Important safety information:
- Chlordiazepoxide injection may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to chlordiazepoxide injection. Using chlordiazepoxide injection alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks for up to 48 hours after use.
- Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking chlordiazepoxide injection. Chlordiazepoxide injection will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
- Use chlordiazepoxide injection with extreme caution in CHILDREN; safety and effectiveness have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Chlordiazepoxide injection has been shown to cause harm to the fetus. Avoid becoming pregnant while taking chlordiazepoxide injection. If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using chlordiazepoxide injection during pregnancy. Chlordiazepoxide injection is excreted in breast milk. Do not breast-feed while taking chlordiazepoxide injection.
When used for long periods of time or at high doses, chlordiazepoxide injection may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if chlordiazepoxide injection stops working well. Do not take more than prescribed.
Chlordiazepoxide injection may be habit-forming and lead to DEPENDENCE if used in high doses or for a long period of time. If you are on long-term or high dosage therapy, you may have WITHDRAWAL symptoms (eg, convulsions, tremor, stomach and muscle cramps, vomiting, sweating) if you suddenly stop taking chlordiazepoxide injection. Do not stop therapy abruptly or change dosage without asking your pharmacist or doctor. Discuss overuse with your doctor or pharmacist.
Possible side effects of chlordiazepoxide injection:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Blurred vision; clumsiness; confusion; dizziness; drowsiness; dry mouth; headache; pain, swelling, or redness at the injection site; short-term memory loss; unusual weakness.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); birth defects; increased anxiety symptoms (excitement, stimulation, rage).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; clumsiness; deep sleep; diminished reflexes; drowsiness; impaired coordination; loss of consciousness; slow reflexes.Proper storage of chlordiazepoxide injection:
Store the powder at room temperature (59 to 77 degrees F) (15 to 25 degrees C). Store away from heat and light. Do not store in the bathroom. Store the special liquid used for mixing in the refrigerator (36 to 46 degrees F; 2 to 8 degrees C). Do not freeze. Prepare solution immediately before using. Throw away any unused solution. Chlordiazepoxide injection may not be prepared and stored for later use. Keep chlordiazepoxide injection, as well as needles and syringes, out of the reach of children and away from pets.
- If you have any questions about chlordiazepoxide injection, please talk with your doctor, pharmacist, or other health care provider.
- Chlordiazepoxide injection is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about chlordiazepoxide injection. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about chlordiazepoxide
- Chlordiazepoxide (Advanced Reading)
- Chlordiazepoxide hydrochloride (Advanced Reading)