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Chlorcyclizine/ phenylephrine

Generic Name: chlorcyclizine/phenylephrine (klor-SYE-klih-zeen/FEN-il-EF-rin)
Brand Name: Dallergy

Chlorcyclizine/ phenylephrine is used for:

Relieving symptoms of sinus congestion; pressure; runny nose; itching of the nose or throat; itchy, watery eyes; and sneezing due to colds, hay fever, or allergies. It may also be used for other conditions as determined by your doctor.

Chlorcyclizine/phenylephrine is an antihistamine and decongestant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The decongestant promotes sinus and nasal drainage, which relieves congestion and pressure.

Do NOT use chlorcyclizine/ phenylephrine if:

  • you are allergic to any ingredient in chlorcyclizine/phenylephrine
  • you have severe or uncontrolled high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
  • you are unable to urinate or are having an asthma attack
  • you are taking droxidopa or sodium oxybate (GHB), or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

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Before using chlorcyclizine/ phenylephrine:

Some medical conditions may interact with chlorcyclizine/phenylephrine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, plan to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of adrenal gland problems (eg, adrenal gland tumor), heart problems (eg, cor pulmonale; fast, slow, or irregular heartbeat; heart disease), high blood pressure, diabetes, blood vessel problems, stroke, glaucoma or increased pressure in the eye, seizures, thyroid problems, or trouble sleeping
  • if you have a history of asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems (eg, chronic bronchitis, emphysema); chronic cough; or sleep apnea
  • if you have a blockage of your bladder, stomach, or bowels; ulcers; an enlarged prostate or other prostate problems; or trouble urinating
  • if you are taking medicine for high blood pressure

Some MEDICINES MAY INTERACT with chlorcyclizine/phenylephrine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, linezolid, MAOIs (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of chlorcyclizine/phenylephrine's side effects
  • Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by chlorcyclizine/phenylephrine
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by chlorcyclizine/phenylephrine

This may not be a complete list of all interactions that may occur. Ask your health care provider if chlorcyclizine/phenylephrine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use chlorcyclizine/ phenylephrine:

Use chlorcyclizine/phenylephrine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take chlorcyclizine/phenylephrine by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • If you miss a dose of chlorcyclizine/phenylephrine and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use chlorcyclizine/phenylephrine.

Important safety information:

  • Chlorcyclizine/phenylephrine may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use chlorcyclizine/phenylephrine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol while you are using chlorcyclizine/phenylephrine.
  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using chlorcyclizine/phenylephrine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do not take diet or appetite control medicines while you are taking chlorcyclizine/phenylephrine without checking with your doctor.
  • Before you start any new medicine, check the label to see if it has a decongestant or an antihistamine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Do NOT take more than the recommended dose or take for longer than prescribed without checking with your doctor.
  • If your symptoms do not get better within 7 days, if they get worse, if they occur along with a fever, or if new symptoms occur, check with your doctor.
  • Chlorcyclizine/phenylephrine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to chlorcyclizine/phenylephrine. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Chlorcyclizine/phenylephrine may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking chlorcyclizine/phenylephrine for a few days before the tests.
  • Tell your doctor or dentist that you take chlorcyclizine/phenylephrine before you receive any medical or dental care, emergency care, or surgery.
  • Use chlorcyclizine/phenylephrine with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, dizziness, drowsiness, dry mouth, excitability, low blood pressure, and trouble urinating.
  • Caution is advised when using chlorcyclizine/phenylephrine in CHILDREN; they may be more sensitive to its effects, especially excitability.
  • Chlorcyclizine/phenylephrine should not be used in CHILDREN younger than 6 years old without first checking with the child's doctor; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using chlorcyclizine/phenylephrine while you are pregnant. Chlorcyclizine/phenylephrine may be found in breast milk. Do not breast-feed while taking chlorcyclizine/phenylephrine.

Possible side effects of chlorcyclizine/ phenylephrine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty urinating or inability to urinate; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; mental or mood changes (eg, nervousness); persistent trouble sleeping; restlessness; seizures; severe or persistent dizziness, drowsiness, light-headedness, or headache; tremor; vision changes (eg, blurred vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; ringing in the ears; seizures; severe dizziness, light-headedness, or headache; severe drowsiness; unusually fast, slow, or irregular breathing; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of chlorcyclizine/phenylephrine:

Store chlorcyclizine/phenylephrine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep chlorcyclizine/phenylephrine out of the reach of children and away from pets.

General information:

  • If you have any questions about chlorcyclizine/phenylephrine, please talk with your doctor, pharmacist, or other health care provider.
  • Chlorcyclizine/phenylephrine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take chlorcyclizine/phenylephrine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about chlorcyclizine/phenylephrine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to chlorcyclizine/phenylephrine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using chlorcyclizine/phenylephrine.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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