Carisoprodol/ aspirin

Generic Name: carisoprodol/aspirin (kar-EYE-soe-PROE-dol/AS-pir-in)
Brand Name: Generic only. No brand available.

Carisoprodol/ aspirin is used for:

Short-term (up to 2 to 3 weeks) relief of discomfort caused by certain painful muscle conditions.

Carisoprodol/aspirin is a muscle relaxant and analgesic combination. The analgesic works by blocking certain chemicals in the body that cause pain and inflammation. The muscle relaxant works in the brain and nervous system to relax the muscles.

Do NOT use carisoprodol/ aspirin if:

  • you are allergic to any ingredient in carisoprodol/aspirin or to a carbamate medicine (eg, meprobamate)
  • you have had a severe reaction (eg, asthma or wheezing, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or a nonsteroidal anti-inflammatory drug (NSAID) (eg, celecoxib, ibuprofen, naproxen)
  • you have a history of serious stomach or bowel problems (eg, bleeding, perforations, blockage) caused by aspirin use
  • you have a history of a certain blood disease (acute intermittent porphyria)
  • you have a low blood platelet level (thrombocytopenia) or certain bleeding or clotting problems (hemophilia), or you are actively bleeding
  • the patient is a child with a viral infection (eg, chickenpox, flu symptoms)
  • you are taking ketorolac, meprobamate, or sodium oxybate (GHB); or you have received a varicella or influenza vaccine within the past 6 weeks

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: 2014 Update - First Time Brand-to-Generic Switches

Before using carisoprodol/ aspirin:

Some medical conditions may interact with carisoprodol/aspirin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of asthma or other lung or breathing problems, growths in the nose (eg, nasal polyps), liver or kidney problems, thyroid problems, bleeding or clotting problems, thrombocytopenia, or heart problems
  • if you have a history of stomach or bowel problems (eg, bleeding, ulcers), bleeding in the brain or stroke, seizures, or the blood disease porphyria
  • if you have low levels of vitamin K in the blood; chickenpox, the flu, or other viral illness; or Kawasaki syndrome
  • if you drink alcohol or you have a history of alcohol or other substance abuse or dependence
  • if you are in poor health

Some MEDICINES MAY INTERACT with carisoprodol/aspirin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Benzodiazepines (eg, alprazolam), opioid (narcotic) pain medicines (eg, hydrocodone), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because the risk of severe drowsiness may be increased
  • Anagrelide, anticoagulants (eg, heparin, warfarin), apixaban, clopidogrel, dabigatran, desirudin, NSAIDs (eg, celecoxib, ibuprofen, ketorolac, naproxen), rivaroxaban, or selective serotonin reuptake blockers (eg, fluoxetine, venlafaxine) because the risk of bleeding (eg, stomach or bowel bleeding) may be increased
  • Influenza or varicella vaccines because the risk of Reye syndrome may be increased
  • Fluvoxamine, meprobamate, omeprazole, or urinary acidifiers (eg, ammonium chloride) because they may increase the risk of carisoprodol/aspirin's side effects
  • Antacids, corticosteroids (eg, prednisone), rifampin, St. John's wort, or urinary alkalinizers (eg, sodium bicarbonate) because they may decrease carisoprodol/aspirin's effectiveness
  • Carbonic anhydrase inhibitors (eg, acetazolamide), insulin, methotrexate, nateglinide, repaglinide, sulfonylureas (eg, glipizide), or valproic acid because the risk of their side effects may be increased by carisoprodol/aspirin
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, lisinopril), angiotensin receptor blockers (ARBs) (eg, losartan), beta-blockers (eg, propranolol), diuretics (eg, furosemide, hydrochlorothiazide), probenecid, spironolactone, or sulfinpyrazone because their effectiveness may be decreased by carisoprodol/aspirin

This may not be a complete list of all interactions that may occur. Ask your health care provider if carisoprodol/aspirin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use carisoprodol/ aspirin:

Use carisoprodol/aspirin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take carisoprodol/aspirin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • If you miss a dose of carisoprodol/aspirin and you are taking it regularly, take it as soon as possible. If it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use carisoprodol/aspirin.

Important safety information:

  • Carisoprodol/aspirin may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use carisoprodol/aspirin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol while you are using carisoprodol/aspirin.
  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using carisoprodol/aspirin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Carisoprodol/aspirin may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Serious and sometimes fatal stomach or bowel problems (eg, bleeding perforations, blockage) can occur with the use of carisoprodol/aspirin. This may occur with or without warning signs. Taking carisoprodol/aspirin in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Patients with a history of stomach or bowel bleeding, or ulcers caused by aspirin use may also be at increased risk. Taking carisoprodol/aspirin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach pain or constipation; black, tarry stools; or vomit that looks like blood or coffee grounds.
  • Aspirin has been linked to a serious illness called Reye syndrome. Do not give carisoprodol/aspirin to a child or teenager who has the flu, chickenpox, or a viral infection. Do not give carisoprodol/aspirin to a child or teenager who has recently received a flu or chickenpox vaccine. Contact your doctor with any questions or concerns.
  • Carisoprodol/aspirin has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin, another salicylate, or an NSAID in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Tell your doctor or dentist that you take carisoprodol/aspirin before you receive any medical or dental care, emergency care, or surgery.
  • Do not take other aspirin products while you are using carisoprodol/aspirin unless your doctor tells you to.
  • Use carisoprodol/aspirin with caution in the ELDERLY; they may be more sensitive to its effects, especially stomach or bowel problems.
  • Carisoprodol/aspirin should be used with extreme caution in CHILDREN younger than 16 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using carisoprodol/aspirin while you are pregnant. Carisoprodol/aspirin is not recommended after 29 weeks of pregnancy because it may cause harm to the fetus. Carisoprodol/aspirin is found in breast milk. Do not breast-feed while taking carisoprodol/aspirin.

Some people who use carisoprodol/aspirin for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.

If you have been taking carisoprodol/aspirin regularly or for a prolonged period of time and you suddenly stop taking it, you may experience WITHDRAWAL symptoms.

Possible side effects of carisoprodol/ aspirin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; headache; indigestion; nausea; mild stomach pain or upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); black, tarry, or bloody stools; change in the amount of urine produced; difficult or painful urination; fainting; fast heartbeat; fever, chills, or persistent sore throat; flushing; loss of appetite; loss of coordination; mood or mental changes (eg, agitation, depression, irritability); ringing in the ears; seizures; severe or persistent dizziness, drowsiness, or headache; severe or persistent stomach pain or upset, constipation, or vomiting; severe or persistent trouble sleeping; tremors; unusual bruising or bleeding; unusual tiredness or weakness; vomit that looks like coffee grounds; weight loss; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include black, tarry, or bloody stools; blurred or dim vision; coma; confusion; diarrhea; enlarged pupils; fainting; fast or irregular heartbeat; fast, slow, shallow, or difficult breathing; fever; hallucinations; hearing problems; increased thirst; loss of consciousness; loss of coordination; mental or mood changes; rigid muscles; ringing in the ears; seizures; severe or unusual drowsiness, dizziness, headache, nausea, stomach pain, or vomiting; shortness of breath; sluggishness; sweating; uncontrollable or involuntary muscle movements; uncontrolled eye movements; vomit that looks like coffee grounds.

Proper storage of carisoprodol/aspirin:

Store carisoprodol/aspirin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep carisoprodol/aspirin out of the reach of children and away from pets.

General information:

  • If you have any questions about carisoprodol/aspirin, please talk with your doctor, pharmacist, or other health care provider.
  • Carisoprodol/aspirin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take carisoprodol/aspirin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about carisoprodol/aspirin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to carisoprodol/aspirin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using carisoprodol/aspirin.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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