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Carbinoxamine/ dextromethorphan/ pseudoephedrine drops

Generic Name: carbinoxamine/dextromethorphan/pseudoephedrine (car-bi-NOX-ah-meen/dex-troe-meth-OR-fan/sue-doe-eh-FED-rin)
Brand Name: Examples include Andehist DM NR and Carbodex DM

Carbinoxamine/ dextromethorphan/ pseudoephedrine drops is used for:

Relieving symptoms of sinus congestion, runny nose, sneezing, and cough due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Carbinoxamine/dextromethorphan/pseudoephedrine drops is a decongestant, antihistamine, and cough suppressant combination. It works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing while the cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.

Do NOT use carbinoxamine/ dextromethorphan/ pseudoephedrine drops if:

  • you are allergic to any ingredient in carbinoxamine/dextromethorphan/pseudoephedrine drops
  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
  • you are unable to urinate or are having an asthma attack
  • you take sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using carbinoxamine/ dextromethorphan/ pseudoephedrine drops:

Some medical conditions may interact with carbinoxamine/dextromethorphan/pseudoephedrine drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a fast, slow, or irregular heartbeat
  • if you have a history of adrenal gland problems (eg, adrenal gland tumor); heart problems; high blood pressure; diabetes; heart blood vessel problems; stroke; glaucoma; a blockage of your stomach, bladder, or intestines; ulcers; trouble urinating; an enlarged prostate or other prostate problems; seizures; or an overactive thyroid
  • if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus

Some MEDICINES MAY INTERACT with carbinoxamine/dextromethorphan/pseudoephedrine drops. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAOIs (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of carbinoxamine/dextromethorphan/pseudoephedrine drops's side effects
  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by carbinoxamine/dextromethorphan/pseudoephedrine drops
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by carbinoxamine/dextromethorphan/pseudoephedrine drops

This may not be a complete list of all interactions that may occur. Ask your health care provider if carbinoxamine/dextromethorphan/pseudoephedrine drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use carbinoxamine/ dextromethorphan/ pseudoephedrine drops:

Use carbinoxamine/dextromethorphan/pseudoephedrine drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take carbinoxamine/dextromethorphan/pseudoephedrine drops by mouth with or without food.
  • Use the dropper that comes with carbinoxamine/dextromethorphan/pseudoephedrine drops to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of carbinoxamine/dextromethorphan/pseudoephedrine drops, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use carbinoxamine/dextromethorphan/pseudoephedrine drops.

Important safety information:

  • Carbinoxamine/dextromethorphan/pseudoephedrine drops may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use carbinoxamine/dextromethorphan/pseudoephedrine drops with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not take diet or appetite control medicines while you are taking carbinoxamine/dextromethorphan/pseudoephedrine drops without checking with you doctor.
  • Carbinoxamine/dextromethorphan/pseudoephedrine drops has pseudoephedrine in it. Before you start any new medicine, check the label to see if it has pseudoephedrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.
  • Carbinoxamine/dextromethorphan/pseudoephedrine drops may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to carbinoxamine/dextromethorphan/pseudoephedrine drops. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Carbinoxamine/dextromethorphan/pseudoephedrine drops may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking carbinoxamine/dextromethorphan/pseudoephedrine drops for a few days before the tests.
  • Tell your doctor or dentist that you take carbinoxamine/dextromethorphan/pseudoephedrine drops before you receive any medical or dental care, emergency care, or surgery.
  • Use carbinoxamine/dextromethorphan/pseudoephedrine drops with caution in the ELDERLY; they may be more sensitive to its effects.
  • Caution is advised when using carbinoxamine/dextromethorphan/pseudoephedrine drops in CHILDREN; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using carbinoxamine/dextromethorphan/pseudoephedrine drops while you are pregnant. It is not known if carbinoxamine/dextromethorphan/pseudoephedrine drops is found in breast milk. Do not breast-feed while taking carbinoxamine/dextromethorphan/pseudoephedrine drops.

Possible side effects of carbinoxamine/ dextromethorphan/ pseudoephedrine drops:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; trouble sleeping; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of carbinoxamine/dextromethorphan/pseudoephedrine drops:

Store carbinoxamine/dextromethorphan/pseudoephedrine drops at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep carbinoxamine/dextromethorphan/pseudoephedrine drops out of the reach of children and away from pets.

General information:

  • If you have any questions about carbinoxamine/dextromethorphan/pseudoephedrine drops, please talk with your doctor, pharmacist, or other health care provider.
  • Carbinoxamine/dextromethorphan/pseudoephedrine drops is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about carbinoxamine/dextromethorphan/pseudoephedrine drops. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 5, 2014
Database Edition 14.4.1.002
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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