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Capastat

Generic Name: capreomycin (KAP-ree-oh-MYE-sin)
Brand Name: Capastat

Capastat should be used with extreme caution in patients with hearing or kidney problems, because it may increase hearing problems or kidney damage. Other injectable medicines used to treat tuberculosis (eg, streptomycin, viomycin) should not be used along with Capastat because the risk of hearing or kidney problems may be further increased. Other medicines that may cause hearing or kidney problems (eg, amikacin, colistin, gentamicin, kanamycin, neomycin, polymyxin A, tobramycin, vancomycin) should be used with extreme caution.

Safety and effectiveness of Capastat in pregnancy or in children have not been confirmed.


Capastat is used for:

Treating lung infections caused by certain strains of tuberculosis (TB). It is used with other medications, and it is only used in those patients who have not responded to or cannot use other specific medicines.

Capastat is a polypeptide antibiotic. It works by killing or stopping the growth of TB organisms.

Do NOT use Capastat if:

  • you are allergic to any ingredient in Capastat
  • you are taking other injectable medicines for TB (eg, streptomycin, viomycin)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Capastat:

Some medical conditions may interact with Capastat. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have hearing problems, kidney problems, liver problems, blood electrolyte (eg, sodium, potassium) problems, Parkinson disease, nerve impairment, or myasthenia gravis

Some MEDICINES MAY INTERACT with Capastat. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nondepolarizing muscle relaxants (eg, pancuronium) because their actions and the risk of their side effects may be increased by Capastat
  • Amikacin, colistin, gentamicin, kanamycin, neomycin, polymyxin A, streptomycin, tobramycin, vancomycin, or viomycin because the risk of serious hearing or kidney side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Capastat may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Capastat:

Use Capastat as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Capastat is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Capastat at home, a health care provider will teach you how to use it. Be sure you understand how to use Capastat. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Capastat if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Capastat may turn a pale straw color that might darken with time. This is normal.
  • To clear up your infection completely, use Capastat for the full course of treatment. Keep using it even if you feel better in a few days.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Capastat, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Capastat.

Important safety information:

  • Capastat only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Be sure to use Capastat for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Long-term or repeated use of Capastat may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Tell your doctor or dentist that you take Capastat before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including kidney function, liver function, blood calcium levels, blood potassium levels, blood magnesium levels, or hearing tests, may be performed while you use Capastat. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Capastat with caution in the ELDERLY; they may be more sensitive to its effects.
  • Capastat is not recommended for use in CHILDREN; safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Capastat, contact your doctor. You will need to discuss the benefits and risks of using Capastat while you are pregnant. It is not know if Capastat is found in breast milk. If you are or will be breast feeding while you are using Capastat, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Capastat:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Pain, swelling, redness, or a hard lump at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decreased hearing or hearing loss; decreased urination or other urination problems; fever, chills, or sore throat; hearing loss; ringing in the ears; sensation that the room is spinning; severe bleeding at the injection site; signs of electrolyte problems (eg, confusion; irregular heartbeat; mental or mood changes; muscle pain, weakness, or cramping).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness; loss of ability to hear high tones; ringing in the ears; sensation that the room is spinning.

Proper storage of Capastat:

Capastat is usually handled and stored by a health care provider. If you are using Capastat at home, store Capastat as directed by your pharmacist or health care provider. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Capastat out of the reach of children and away from pets.

General information:

  • If you have any questions about Capastat, please talk with your doctor, pharmacist, or other health care provider.
  • Capastat is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Capastat or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Capastat. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Capastat. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Capastat.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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