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Busulfan tablet

Generic Name: busulfan (byoo-SUL-fan)
Brand Name: Myleran

Busulfan tablet may cause severe bone marrow depression, which can reduce the body's ability to fight infection or cancer. Lab tests will be required to monitor therapy. Busulfan tablet may also increase the risk of developing a second cancer.


Busulfan tablet is used for:

Treating the symptoms of chronic myelogenous leukemia.

Busulfan tablet is an alkylating agent. It works by slowing down reproduction and growth of certain white blood cells, which helps the body fight leukemia.

Do NOT use busulfan tablet if:

  • you are allergic to any ingredient in busulfan tablet
  • you are also taking metronidazole or have recently been vaccinated with a live vaccine

Contact your doctor or health care provider right away if any of these apply to you.

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Before using busulfan tablet:

Some medical conditions may interact with busulfan tablet. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bone marrow depression, blood problems (eg, porphyria, thalassemia), a head injury, or a history of seizures (eg, epilepsy)
  • if you have undergone chemotherapy or radiation or have previously or are currently taking any other medicines for cancer
  • if you are overweight

Some MEDICINES MAY INTERACT with busulfan tablet. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Metronidazole, acetaminophen, or itraconazole because the toxic side effects of busulfan tablet may be increased
  • Cyclophosphamide because the risk of serious heart side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if busulfan tablet may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use busulfan tablet:

Use busulfan tablet as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Busulfan tablet may be taken with or without food. If nausea or vomiting occurs, it may help to take busulfan tablet on an empty stomach.
  • Busulfan tablet works best if it is taken at the same time each day.
  • Drinking extra fluids while you are taking busulfan tablet is recommended. Check with your doctor or nurse for instructions.
  • If you miss a dose of busulfan tablet, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use busulfan tablet.

Important safety information:

  • Busulfan tablet may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to busulfan tablet. Using busulfan tablet alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Busulfan tablet may lower your resistance to infection. Prevent infection by avoiding contact with people with colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first.
  • Busulfan tablet may reduce the number of certain blood cells that are needed for clotting. To prevent bleeding, avoid situations where bruising or injury may occur.
  • Check with your doctor before having vaccinations while you are using busulfan tablet.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using busulfan tablet.
  • Busulfan tablet increases the risk of a second cancer in future years. If you have questions about this risk, talk with your doctor.
  • The use of birth control is recommended while you are taking busulfan tablet.
  • Busulfan tablet may cause infertility. Talk with your doctor if you have any questions or concerns.
  • LAB TESTS, including liver function tests, blood cell counts, and bone marrow tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: Busulfan tablet has been shown to cause harm to the fetus. Avoid becoming pregnant while you are taking busulfan tablet. If you suspect you may be pregnant, discuss with your doctor the benefits and risks of using busulfan tablet during pregnancy. It is unknown if busulfan tablet is excreted in breast milk. Do not breast-feed while taking busulfan tablet.

Possible side effects of busulfan tablet:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Darkening of the skin; diarrhea; dizziness; dry mouth, nose, and throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abrupt weakness; chest pain; confusion; congestion; decreased ability to fight infection; fever, chills, or sore throat; infertility; loss of appetite; missed menstrual period; nausea; persistent cough; seizures; shortness of breath; stomach or joint pain; unusual bruising or bleeding; unusual tiredness or fatigue; vision changes; vomiting; weight loss; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of busulfan tablet:

Store busulfan tablet at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep busulfan tablet out of the reach of children and away from pets.

General information:

  • If you have any questions about busulfan tablet, please talk with your doctor, pharmacist, or other health care provider.
  • Busulfan tablet is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take busulfan tablet or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about busulfan tablet. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to busulfan tablet. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using busulfan tablet.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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