Brompheniramine/ dextromethorphan/ guaifenesin/ pseudoephedrine syrup

Generic Name: brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine (brome-fen-IR-a-meen/DEX-troe-meth-OR-fan/gwye-FEN-e-sin/SOO-doe-e-FED-rin)
Brand Name: Bromhist-DM

Brompheniramine/ dextromethorphan/ guaifenesin/ pseudoephedrine syrup is used for:

Relieving symptoms of sinus congestion, runny nose, sneezing, itchy nose or throat, itchy or watery eyes, and cough due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup is an antihistamine, decongestant, cough suppressant, and expectorant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The expectorant works by loosening mucus and lung secretions in the chest, making coughs more productive. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.

Do NOT use brompheniramine/ dextromethorphan/ guaifenesin/ pseudoephedrine syrup if:

  • you are allergic to any ingredient in brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup
  • you have severe high blood pressure, severe heart blood vessel disease, a rapid heartbeat, or severe heart problems
  • you are unable to urinate or are having an asthma attack
  • you take droxidopa, sodium oxybate (GHB), or if you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using brompheniramine/ dextromethorphan/ guaifenesin/ pseudoephedrine syrup:

Some medical conditions may interact with brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of adrenal gland problems (eg, adrenal gland tumor), heart problems (eg, fast, slow, or irregular heartbeat; heart disease), high or low blood pressure, low blood volume, diabetes, blood vessel problems, stroke, glaucoma or increased pressure in the eye, or thyroid problems
  • if you have a history of asthma, chronic cough, lung or breathing problems (eg, chronic bronchitis, emphysema, sleep apnea), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus
  • if you have a history of stomach or bowel ulcers; a blockage of your stomach, bladder, or bowel; kidney problems; trouble urinating; or an enlarged prostate or other prostate problems

Some MEDICINES MAY INTERACT with brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Beta-blockers (eg, propranolol), furazolidone, linezolid, MAOIs (eg, phenelzine), selective serotonin reuptake inhibitors (SSRIs) (eg, citalopram, fluoxetine), sodium oxybate (GHB), tricyclic antidepressants (eg, amitriptyline), or urinary alkalinizers (eg, sodium bicarbonate) because they may increase the risk of brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup's side effects
  • Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup

This may not be a complete list of all interactions that may occur. Ask your health care provider if brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use brompheniramine/ dextromethorphan/ guaifenesin/ pseudoephedrine syrup:

Use brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup.

Important safety information:

  • Brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do not take diet or appetite control medicines while you are taking brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup without checking with your doctor.
  • Before you start any new medicine, check the label to see if it has a decongestant, antihistamine, expectorant, or cough suppressant in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Do not use brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.
  • Brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup for a few days before the tests.
  • Tell your doctor or dentist that you take brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup before you receive any medical or dental care, emergency care, or surgery.
  • Use brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, drowsiness, dizziness, dry mouth, nervousness, sleeplessness, and trouble urinating.
  • Caution is advised when using brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup in CHILDREN; they may be more sensitive to its effects, especially excitability.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup while you are pregnant. Some ingredients of brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup are found in breast milk. Do not breast-feed while taking brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup.

Possible side effects of brompheniramine/ dextromethorphan/ guaifenesin/ pseudoephedrine syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty urinating or inability to urinate; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; loss of coordination; mental or mood changes (eg, depression); seizures; severe dizziness, drowsiness, lightheadedness, or headache; severe dryness of mouth, nose, and throat; severe or persistent trouble sleeping; shortness of breath; tremor; unusual bruising or bleeding; unusual tiredness or weakness; vision problems (eg, double vision, severe or persistent blurred vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; flushing; hallucinations; mental or mood changes; muscle spasms; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; trouble breathing; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup:

Store brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup out of the reach of children and away from pets.

General information:

  • If you have any questions about brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup, please talk with your doctor, pharmacist, or other health care provider.
  • Brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine syrup.

Issue Date: November 5, 2014
Database Edition 14.4.1.002
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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