Anti-thymocyte globulin (rabbit)

Generic Name: anti-thymocyte globulin (rabbit) (AN-tye THYE-moe-site GLOB-yoo-lin)
Brand Name: Thymoglobulin

Anti-thymocyte globulin (rabbit) should only be given by a doctor in a medical setting under the supervision of a doctor who is experienced in management of organ transplant patients.


Anti-thymocyte globulin (rabbit) is used for:

Treating acute kidney transplant rejection with other medicines used to suppress the immune system. It may also be used for other conditions as determined by your doctor.

Anti-thymocyte globulin (rabbit) is an immune globulin. It works by suppressing the body's immune response, but the way it does this is not fully understood.

Do NOT use anti-thymocyte globulin (rabbit) if:

  • you are allergic to any ingredient in anti-thymocyte globulin (rabbit)
  • you are allergic to rabbit products
  • you have an acute viral illness

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: 2013 Drug News Round-Up: Top 20 Stories

Before using anti-thymocyte globulin (rabbit):

Some medical conditions may interact with anti-thymocyte globulin (rabbit). Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart failure, shortness of breath, or swelling in the legs
  • if you have low blood platelets or a low white blood cell count
  • if you have high blood sodium or potassium, or kidney or liver problems

Some MEDICINES MAY INTERACT with anti-thymocyte globulin (rabbit). However, no specific interactions with anti-thymocyte globulin (rabbit) are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if anti-thymocyte globulin (rabbit) may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use anti-thymocyte globulin (rabbit):

Use anti-thymocyte globulin (rabbit) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Anti-thymocyte globulin (rabbit) is only administered as an injection by health care providers in a medical setting.
  • If anti-thymocyte globulin (rabbit) contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • You may be given other medicines (eg, acetaminophen, corticosteroids, an antihistamine) to decrease the side effects of anti-thymocyte globulin (rabbit).
  • If you miss a dose of anti-thymocyte globulin (rabbit), contact your doctor immediately.

Ask your health care provider any questions you may have about how to use anti-thymocyte globulin (rabbit).

Important safety information:

  • Anti-thymocyte globulin (rabbit) may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to anti-thymocyte globulin (rabbit). Using anti-thymocyte globulin (rabbit) alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Anti-thymocyte globulin (rabbit) may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • Anti-thymocyte globulin (rabbit) may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first. Notify your doctor of any signs of infection including fever, sore throat, rashes, or chills.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using anti-thymocyte globulin (rabbit).
  • Anti-thymocyte globulin (rabbit) can affect the results of certain lab tests. Make sure lab personnel and your doctors know you use anti-thymocyte globulin (rabbit).
  • Check with your doctor before having vaccinations while you are using anti-thymocyte globulin (rabbit).
  • Carry an identification card at all times that says you taking this medication.
  • LAB TESTS, including blood tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use anti-thymocyte globulin (rabbit) with caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using anti-thymocyte globulin (rabbit) during pregnancy. It is unknown if anti-thymocyte globulin (rabbit) is excreted in breast milk. If you are or will be breast-feeding while you are using anti-thymocyte globulin (rabbit), check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of anti-thymocyte globulin (rabbit):

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Chills; diarrhea; dizziness; fever; general body discomfort; headache; nausea; swelling of the hands and feet; urinary tract infection; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); diarrhea; dizziness; easy bleeding or bruising; fast or irregular heartbeat; fever; infection; joint or muscle pain; persistent sore throat; stomach pain; unusual fatigue.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of anti-thymocyte globulin (rabbit):

Anti-thymocyte globulin (rabbit) is usually handled and stored by a health care provider. If you are using anti-thymocyte globulin (rabbit) at home, store anti-thymocyte globulin (rabbit) as directed by your pharmacist or health care provider. Keep anti-thymocyte globulin (rabbit) out of the reach of children and away from pets.

General information:

  • If you have any questions about anti-thymocyte globulin (rabbit), please talk with your doctor, pharmacist, or other health care provider.
  • Anti-thymocyte globulin (rabbit) is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take anti-thymocyte globulin (rabbit) or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about anti-thymocyte globulin (rabbit). It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to anti-thymocyte globulin (rabbit). This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using anti-thymocyte globulin (rabbit).

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Hide
(web5)