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Amphotericin b lipid complex

Generic Name: amphotericin b lipid complex (am-foe-TER-ih-sin B)
Brand Name: Abelcet

Amphotericin b lipid complex is used for:

Treating invasive fungal infections in patients who cannot tolerate other forms of amphotericin b lipid complex.

Amphotericin b lipid complex is an antifungal antibiotic. It works by killing the fungus and preventing its reproduction.

Do NOT use amphotericin b lipid complex if:

  • you are allergic to any ingredient in amphotericin b lipid complex
  • you are receiving a transfusion of a certain type of white blood cell (leukocyte)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using amphotericin b lipid complex:

Some medical conditions may interact with amphotericin b lipid complex. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney problems

Some MEDICINES MAY INTERACT with amphotericin b lipid complex. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Medicines used to treat cancer because the risk of kidney problems, breathing problems, and low blood pressure may be increased
  • Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], pentamidine, tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney
  • Digoxin because the risk of low blood potassium levels, which may increase the risk of digoxin's side effects, may be increased
  • Azole antifungals (eg, ketoconazole) because they may decrease amphotericin b lipid complex's effectiveness
  • Corticosteroids (eg, prednisone) or corticotropin because the risk of low blood potassium levels, which may lead to heart problems, may be increased
  • Flucytosine or zidovudine because the risk of their side effects may be increased by amphotericin b lipid complex

This may not be a complete list of all interactions that may occur. Ask your health care provider if amphotericin b lipid complex may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use amphotericin b lipid complex:

Use amphotericin b lipid complex as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Amphotericin b lipid complex will be administered as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
  • If you miss a dose of amphotericin b lipid complex, contact your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use amphotericin b lipid complex.

Important safety information:

  • Tell your doctor or dentist that you take amphotericin b lipid complex before you receive any medical or dental care, emergency care, or surgery.
  • Some people have had side effects within a few hours of the start of the infusion. Tell your doctor if you have any bad effects during this time.
  • Be sure to use amphotericin b lipid complex for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Lab tests may be performed while you use amphotericin b lipid complex. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using amphotericin b lipid complex while you are pregnant. It is not known if amphotericin b lipid complex is found in breast milk. Do not breast-feed while taking amphotericin b lipid complex.

Possible side effects of amphotericin b lipid complex:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; chest pain; dark, bloody stools; dark urine; decreased urination; easy bruising or bleeding; fainting; fast or irregular heartbeat; fever or chills; pain, redness, or inflammation at the injection site; seizures; severe dizziness; shortness of breath; unusual tiredness or weakness; vomiting blood or vomit that looks like coffee grounds; yellowing of eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of amphotericin b lipid complex:

Amphotericin b lipid complex will be handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.

General information:

  • If you have any questions about amphotericin b lipid complex, please talk with your doctor, pharmacist, or other health care provider.
  • Amphotericin b lipid complex is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take amphotericin b lipid complex or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about amphotericin b lipid complex. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to amphotericin b lipid complex. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using amphotericin b lipid complex.

Issue Date: March 4, 2015
Database Edition 15.1.1.003
Copyright © 2015 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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