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Alprostadil suppository

Pronunciation

Generic Name: alprostadil (al-PRAHST-uh-dill)
Brand Name: Muse

Alprostadil suppository is used for:

Treating erectile problems in men.

Alprostadil suppository is a prostaglandin (PGE-1). It induces penile erection by relaxing certain muscles in the penis and widening blood vessels, which increases blood flow to the penis and helps to cause an erection. When the effect of the alprostadil wears off, blood flow returns to normal and the erection disappears.

Do NOT use alprostadil suppository if:

  • you are allergic to any ingredient in alprostadil suppository
  • you have urinary problems (eg, inflammation or narrowing of the urinary tract), blood problems (eg, sickle cell anemia, thrombocytopenia, polycythemia, multiple myeloma, thick or "sticky" blood), blood clotting problems, or a history of blood clots
  • you have inflammation or infection of the penis, your penis is not straight when erect, or your penis is structurally abnormal in any way
  • you have any other physical reason that you should not have sexual intercourse
  • you plan to have sexual intercourse with a pregnant woman (unless you use a condom)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using alprostadil suppository:

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, if you become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have Peyronie disease (scar tissue on your penis) or a prolonged and painful erection
  • if you have a penile implant, leukemia, heart problems, or lung problems (eg, adult respiratory distress syndrome)

Some MEDICINES MAY INTERACT with alprostadil suppository.

  • Anticoagulants (eg, warfarin) because the risk of bleeding may be increased
  • Medicines for high blood pressure because side effects, such as dizziness and fainting, may be increased by alprostadil suppository

This may not be a complete list of all interactions that may occur. Ask your health care provider if alprostadil suppository may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use alprostadil suppository:

Use alprostadil suppository as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Alprostadil suppository comes with an additional patient leaflet. Read it carefully and reread it each time you get alprostadil suppository refilled.
  • Alprostadil suppository should be used as needed to achieve an erection.
  • Use alprostadil suppository exactly as instructed by your health care provider. Before using alprostadil suppository, your health care provider should instruct you on the proper technique for self-administering alprostadil suppository. Contact your health care provider if you have any questions about using alprostadil suppository.
  • Alprostadil suppository works best if you urinate just prior to insertion.
  • Do not use more than 2 systems in a 24-hour period.
  • Each dose is for single use and should be properly thrown away after use.
  • The medicine usually takes effect 5 to 10 minutes after being used. The effect lasts about 30 to 60 minutes. However, the duration will vary from person to person.
  • If you miss a dose of alprostadil suppository, use it as soon as you remember. Continue to use it as directed by your doctor.

Ask your health care provider any questions you may have about how to use alprostadil suppository.

Important safety information:

  • Alprostadil suppository may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to alprostadil suppository. Using alprostadil suppository alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • You will need to have a complete medical history and physical exam before using alprostadil suppository.
  • Wear a condom if you plan to have sexual intercourse with a pregnant woman.
  • Tell your doctor if you experience painful erections or erections that last for more than 4 hours. If prolonged erection is not treated immediately, damage to the penile tissue and loss of potency could result.
  • Alprostadil suppository does not protect against the spread of sexually transmitted diseases (STDs). Take precautions to guard against the spread of STDs, including HIV.
  • If you have not had sexual intercourse for a long time, consult your health care provider before resuming sexual intercourse. It may be necessary to use a water-based lubricant during sexual intercourse.
  • Alprostadil suppository is not recommended for use in CHILDREN; safety and effectiveness have not been established.

Possible side effects of alprostadil suppository:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; burning, bleeding, or spotting of the urethra; flu symptoms; groin pain; pain; penile pain; runny nose; testicular pain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; fast pulse; leg pain; prolonged, painful erections; redness, lumps, swelling, tenderness, or curving of the erect penis; swelling of the leg veins.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; lasting pain in the penis, and painful erections lasting more than 6 hours; lightheadedness.

Proper storage of alprostadil suppository:

Store unopened foil pouches in refrigerator between 36 and 46 degrees F (2 and 8 degrees C). Alprostadil suppository may be stored at room temperature below 86 degrees F (30 degrees C) for up to 14 days. Keep alprostadil suppository out of the reach of children and away from pets.

General information:

  • If you have any questions about alprostadil suppository, please talk with your doctor, pharmacist, or other health care provider.
  • Alprostadil suppository is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take alprostadil suppository or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about alprostadil suppository. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to alprostadil suppository. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using alprostadil suppository.

Issue Date: November 5, 2014
Database Edition 14.4.1.002
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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