Generic Name: loxapine (LOX-a-peen)
Brand Name: Adasuve
Adasuve powder may cause bronchospasm (narrowing of the airways) that can cause serious breathing problems. Your doctor will check you for breathing problems before and after you use Adasuve powder. Tell your doctor right away if you have wheezing, coughing, chest tightness, or shortness of breath after you use Adasuve powder.
Because of the risk of severe breathing problems, Adasuve powder is only available through the Adasuve Risk Evaluation and Mitigation Strategy (REMS) program.
Adasuve powder should only be given in a health care facility enrolled in the Adasuve REMS program. Adasuve powder is an antipsychotic. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Adasuve powder is not approved to treat mental problems caused by dementia.
Adasuve powder is used for:
Treating agitation in certain patients with schizophrenia or bipolar I disorder. It may also be used for other conditions as determined by your doctor.
Adasuve powder is a typical antipsychotic. Exactly how Adasuve powder works is not known.
Do NOT use Adasuve powder if:
- you are allergic to any ingredient in Adasuve powder or to amoxapine
- you have had wheezing following a treatment with Adasuve powder in the past
- you have or have had asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems
- you are having chest tightness, wheezing, coughing, or shortness of breath
- you are taking medicines to treat asthma or COPD
Contact your doctor or health care provider right away if any of these apply to you.
Before using Adasuve powder:
Some medical conditions may interact with Adasuve powder. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of other mental problems, glaucoma, difficulty urinating, neuroleptic malignant syndrome (NMS), Parkinson disease, or seizures
- if you have a history of heart attack or other heart problems (eg, heart failure, irregular heartbeat), stroke or mini-stroke, blood vessel problems (eg, in the brain), or high or low blood pressure
- if you are dehydrated, have low blood volume, drink alcohol, or use street drugs
Some MEDICINES MAY INTERACT with Adasuve powder. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Barbiturates (eg, phenobarbital), benzodiazepines (eg, lorazepam), narcotics (eg, codeine), phenothiazines (eg, chlorpromazine), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects, such as severe breathing problems or severe drowsiness, may be increased
- Anticholinergics (eg, scopolamine) because they may increase the risk of Adasuve powder's side effects
This may not be a complete list of all interactions that may occur. Ask your health care provider if Adasuve powder may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Adasuve powder:
Use Adasuve powder as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Adasuve powder comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Adasuve powder refilled.
- Adasuve powder is for oral inhalation only. It will be given at your doctor's office, hospital, or clinic. Your health care provider will teach you how to use it. Be sure you understand how to use Adasuve powder. Follow the procedures you are taught when you use a dose.
- Your health care provider will check you for breathing problems after you use Adasuve powder and at least every 15 minutes for at least 1 hour after you use it.
- You should receive Adasuve powder only under direct medical supervision by a doctor experienced in the use of Adasuve powder.
- If you miss a dose of Adasuve powder, contact your doctor right away.
Ask your health care provider any questions you may have about how to use Adasuve powder.
Important safety information:
- Adasuve powder may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Adasuve powder with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol while you are using Adasuve powder.
- Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Adasuve powder; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Adasuve powder may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. This may be more likely to occur when you start to take Adasuve powder, and also if your dose increases. To prevent these effects, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke, dizziness, or fainting may occur.
- NMS is a possibly fatal syndrome that can be caused by Adasuve powder. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
- Tell your doctor or dentist that you take Adasuve powder before you receive any medical or dental care, emergency care, or surgery.
- Use Adasuve powder with caution in the ELDERLY because they may be more sensitive to its effects.
- Adasuve powder should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Adasuve powder while you are pregnant. Using Adasuve powder during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. It is not known if Adasuve powder is found in breast milk. Do not breast-feed while taking Adasuve powder.
Possible side effects of Adasuve powder:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Bad, bitter, or metallic taste in the mouth; drowsiness; sore throat.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; cough; fainting; fast or irregular heartbeat; increased sweating; mask-like face; neck spasms; new or worsening mental or mood changes; one-sided weakness; restlessness; seizures; severe or persistent dizziness, light-headedness, or headache; shortness of breath; slurred speech; stiff or rigid muscles; throat tightness; tongue sticking out; tremor; trouble swallowing or breathing; trouble urinating; vision changes; wheezing.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Adasuve powder:
Adasuve powder is handled and stored by a health care provider. Keep Adasuve powder out of the reach of children and away from pets.
- If you have any questions about Adasuve powder, please talk with your doctor, pharmacist, or other health care provider.
- Adasuve powder is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Adasuve powder or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Adasuve powder. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Adasuve powder. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Adasuve powder.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.