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Adapalene and benzoyl peroxide gel

Generic Name: adapalene and benzoyl peroxide (a-DAP-a-leen/BEN-zoe-il per-OX-ide)
Brand Name: Epiduo

Adapalene and benzoyl peroxide gel is used for:

Treating acne. It may also be used for other conditions as determined by your doctor.

Adapalene and benzoyl peroxide gel is a combination of a retinoid and a keratolytic agent with antibacterial activity. Exactly how adapalene and benzoyl peroxide gel works to treat acne is not known. It helps to decrease acne formation by causing skin peeling and killing bacteria that cause acne.

Do NOT use adapalene and benzoyl peroxide gel if:

  • you are allergic to any ingredient in adapalene and benzoyl peroxide gel

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: View Frightful (But Dead Serious) Drug Side Effects

Before using adapalene and benzoyl peroxide gel:

Some medical conditions may interact with adapalene and benzoyl peroxide gel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have eczema, damaged skin, or a sunburn at the affected area
  • if you have a history of skin sensitivity to the sun, or if you spend a lot of time outdoors
  • if you are using other medicine to treat acne, especially medicines containing sulfur, resorcinol, or salicylic acid

Some MEDICINES MAY INTERACT with adapalene and benzoyl peroxide gel. Because little, if any, of adapalene and benzoyl peroxide gel is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if adapalene and benzoyl peroxide gel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use adapalene and benzoyl peroxide gel:

Use adapalene and benzoyl peroxide gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with adapalene and benzoyl peroxide gel. Talk to your pharmacist if you have questions about this information.
  • Do not apply adapalene and benzoyl peroxide gel to eczema or to damaged or sunburned skin.
  • Before applying adapalene and benzoyl peroxide gel, clean the area to be treated with mild soap or soapless cleanser and gently dry.
  • Apply a thin film of adapalene and benzoyl peroxide gel to the affected skin and the surrounding area. Use a pea-sized amount for each area of the face (eg, forehead, chin, cheek) unless your doctor tells you otherwise. Rub in gently.
  • Wash your hands right away after using adapalene and benzoyl peroxide gel.
  • A mild sensation of warmth or slight stinging may occur shortly after using adapalene and benzoyl peroxide gel.
  • If you miss a dose of adapalene and benzoyl peroxide gel, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. If several applications are missed, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use adapalene and benzoyl peroxide gel.

Important safety information:

  • Adapalene and benzoyl peroxide gel is for external use only. Do not get it in your eyes, mouth, nose, or in the angles of your nose. Do not get it in your vagina. If you get it in any of these areas, rinse right away with cool water.
  • Do not use more than the recommended dose or more often than 1 time daily without checking with your doctor. This will not produce faster results and may increase irritation.
  • Acne may worsen in the early stages of using adapalene and benzoyl peroxide gel. This is due to the action of adapalene and benzoyl peroxide gel on unseen lesions. Check with your doctor if your symptoms do not improve after several weeks.
  • Do not use other medicines or products on your skin while you are using adapalene and benzoyl peroxide gel without first checking with your doctor.
  • Do not use irritating products on the affected skin while you are using adapalene and benzoyl peroxide gel. These products may include abrasive soaps and cleansers, soaps and cosmetics with strong skin-drying effects, and products with high amounts of alcohol, astringents, spices, or limes.
  • Cosmetics may be used while you are using adapalene and benzoyl peroxide gel. After using cosmetics, wash and dry the affected area well before you apply adapalene and benzoyl peroxide gel.
  • Adapalene and benzoyl peroxide gel may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to adapalene and benzoyl peroxide gel. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Wind or cold temperatures may irritate the affected area while you are using adapalene and benzoyl peroxide gel.
  • Mild redness, scaling, dryness, stinging, or burning may occur when you start adapalene and benzoyl peroxide gel. These effects usually decrease with continued use of adapalene and benzoyl peroxide gel. Talk with your doctor if these effects continue or become bothersome.
  • Skin moisturizers may be used if necessary. Do not use moisturizers that contain alpha hydroxy or glycolic acids.
  • Certain cosmetic procedures, such as waxing, should not be performed on treated skin due to possible irritation.
  • Adapalene and benzoyl peroxide gel may bleach hair and colored fabrics.
  • Adapalene and benzoyl peroxide gel may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
  • Adapalene and benzoyl peroxide gel should be used with extreme caution in CHILDREN younger than 9 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using adapalene and benzoyl peroxide gel while you are pregnant. It is not known if adapalene and benzoyl peroxide gel is found in breast milk. If you are or will be breast-feeding while you use adapalene and benzoyl peroxide gel, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of adapalene and benzoyl peroxide gel:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry skin; feeling of warmth; irritation; itching; peeling; redness; scaling; temporary burning and stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering; crusting; excessive redness, peeling, or irritation; swelling.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Adapalene and benzoyl peroxide gel may be harmful if swallowed.

Proper storage of adapalene and benzoyl peroxide gel:

Store adapalene and benzoyl peroxide gel at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store with cap tightly closed away from heat, moisture, and light. Do not store in the bathroom. Keep adapalene and benzoyl peroxide gel out of the reach of children and away from pets.

General information:

  • If you have any questions about adapalene and benzoyl peroxide gel, please talk with your doctor, pharmacist, or other health care provider.
  • Adapalene and benzoyl peroxide gel is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take adapalene and benzoyl peroxide gel or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about adapalene and benzoyl peroxide gel. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to adapalene and benzoyl peroxide gel. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using adapalene and benzoyl peroxide gel.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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