Acetaminophen/ guaifenesin/ phenylephrine liquid

Generic Name: acetaminophen/guaifenesin/phenylephrine (a-SEET-a-MIN-oh-fen/gwye-FEN-e-sin/FEN-il-EF-rin)
Brand Name: Theraflu Warming Relief Cold & Chest Congestion

Acetaminophen/ guaifenesin/ phenylephrine liquid is used for:

Relieving cold and flu symptoms such as minor aches and pains, headache, sore throat pain, and congestion. It may also be used for other conditions as determined by your doctor.

Acetaminophen/guaifenesin/phenylephrine liquid is an analgesic, decongestant, and expectorant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The expectorant works by loosening mucus and lung secretions in the chest, making coughs more productive. The analgesic works in the brain to decrease pain.

Do NOT use acetaminophen/ guaifenesin/ phenylephrine liquid if:

  • you are allergic to any ingredient in acetaminophen/guaifenesin/phenylephrine liquid
  • you have severe high blood pressure, rapid heartbeat, severe heart blood vessel disease, or other severe heart problems
  • you are taking droxidopa or if you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: OTC Medication Use In Pregnancy: Wise or Worrisome?

Before using acetaminophen/ guaifenesin/ phenylephrine liquid:

Some medical conditions may interact with acetaminophen/guaifenesin/phenylephrine liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you smoke, drink 3 or more alcohol-containing drinks per day, or have a history of alcoholism
  • if you have trouble sleeping
  • if you have a history of glaucoma, or increased pressure in the eye, an enlarged prostate or other prostate problems, heart problems (eg, fast, slow, or irregular heartbeat), diabetes, high blood pressure, blood vessel problems, adrenal gland problems (eg, pheochromocytoma), thyroid problems, trouble sleeping, seizures, a stroke, liver problems (eg, hepatitis), or kidney problems
  • if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), sleep apnea, or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus
  • if you are taking medicine for high blood pressure or depression

Some MEDICINES MAY INTERACT with acetaminophen/guaifenesin/phenylephrine liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, isoniazid, linezolid, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because the risk of acetaminophen/guaifenesin/phenylephrine liquid's side effects may be increased
  • Anticoagulants (eg, warfarin) because the risk of bleeding may be increased
  • Digoxin or droxidopa because the risk of irregular heartbeat or a heart attack may be increased
  • Bromocriptine because the risk of its side effects may be increased by acetaminophen/guaifenesin/phenylephrine liquid
  • Guanadrel, guanethidine, mecamylamine, medicines for high blood pressure, methyldopa, or reserpine because their effectiveness may be decreased by acetaminophen/guaifenesin/phenylephrine liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if acetaminophen/guaifenesin/phenylephrine liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use acetaminophen/ guaifenesin/ phenylephrine liquid:

Use acetaminophen/guaifenesin/phenylephrine liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take acetaminophen/guaifenesin/phenylephrine liquid by mouth with or without food.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • Drink plenty of water while taking acetaminophen/guaifenesin/phenylephrine liquid.
  • If you miss a dose of acetaminophen/guaifenesin/phenylephrine liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use acetaminophen/guaifenesin/phenylephrine liquid.

Important safety information:

  • Acetaminophen/guaifenesin/phenylephrine liquid may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use acetaminophen/guaifenesin/phenylephrine liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not take appetite suppressants while you use acetaminophen/guaifenesin/phenylephrine liquid unless your doctor tells you otherwise.
  • Acetaminophen/guaifenesin/phenylephrine liquid contains acetaminophen, guaifenesin, and phenylephrine. Before you start any new medicine, check the label to see if it has any of these medicines or similar medicines in it. If it does or if you are not sure, check with your doctor or pharmacist.
  • Do not use acetaminophen/guaifenesin/phenylephrine liquid for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.
  • Do NOT take more than the recommended dose or use for longer than directed without checking with your doctor.
  • If your symptoms do not get better within 7 days, if they come back or get worse, or if new symptoms appear, check with your doctor.
  • If you have a sore throat that lasts more than 2 days, is severe, or is accompanied with headache, fever, rash, nausea, or vomiting, check with your doctor.
  • Contact your doctor if you have a fever that lasts more than 3 days or you have a cough that is accompanied by a persistent headache, fever, or rash.
  • Acetaminophen/guaifenesin/phenylephrine liquid may harm your liver. Your risk may be greater if you drink alcohol while you are using acetaminophen/guaifenesin/phenylephrine liquid. Talk to your doctor before you take acetaminophen/guaifenesin/phenylephrine liquid or other fever reducers if you drink more than 3 drinks with alcohol per day.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
  • Tell your doctor or dentist that you take acetaminophen/guaifenesin/phenylephrine liquid before you receive any medical or dental care, emergency care, or surgery.
  • Acetaminophen/guaifenesin/phenylephrine liquid may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking acetaminophen/guaifenesin/phenylephrine liquid.
  • Acetaminophen/guaifenesin/phenylephrine liquid contains acetaminophen. Adults should not take more than a total of 4 grams (4,000 mg) of acetaminophen in a 24-hour period (3 grams [3,000 mg] per day if you have liver disease). Check with your doctor before taking other pain relievers, cough and cold medicines, or allergy medicines because they may also contain acetaminophen. Acetaminophen may cause liver damage. If you drink alcohol on a daily basis, do not take acetaminophen/guaifenesin/phenylephrine liquid without first discussing it with your doctor. Alcohol use combined with acetaminophen may increase your risk for liver damage (symptoms include yellowing of the skin or eyes, stomach pain, dark urine).
  • Use acetaminophen/guaifenesin/phenylephrine liquid with caution in the ELDERLY; they may be more sensitive to its effects.
  • Caution is advised when using acetaminophen/guaifenesin/phenylephrine liquid in CHILDREN; they may be more sensitive to its effects.
  • Acetaminophen/guaifenesin/phenylephrine liquid should not be used in CHILDREN younger than 12 years old without first checking with the child's doctor; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if acetaminophen/guaifenesin/phenylephrine liquid can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using acetaminophen/guaifenesin/phenylephrine liquid while you are pregnant. Some ingredients of acetaminophen/guaifenesin/phenylephrine liquid may be found in breast milk. If you are or will be breast-feeding while you use acetaminophen/guaifenesin/phenylephrine liquid, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of acetaminophen/ guaifenesin/ phenylephrine liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; difficulty urinating; fast or irregular heartbeat; hallucinations; loss of appetite; pale stools; seizures; severe dizziness, lightheadedness, or headache; stomach pain; tremor; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; stomach pain; unusually fast, slow, or irregular heartbeat; vomiting; yellowing of the skin or eyes.

Proper storage of acetaminophen/guaifenesin/phenylephrine liquid:

Store acetaminophen/guaifenesin/phenylephrine liquid at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep acetaminophen/guaifenesin/phenylephrine liquid out of the reach of children and away from pets.

General information:

  • If you have any questions about acetaminophen/guaifenesin/phenylephrine liquid, please talk with your doctor, pharmacist, or other health care provider.
  • Acetaminophen/guaifenesin/phenylephrine liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take acetaminophen/guaifenesin/phenylephrine liquid or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about acetaminophen/guaifenesin/phenylephrine liquid. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to acetaminophen/guaifenesin/phenylephrine liquid. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using acetaminophen/guaifenesin/phenylephrine liquid.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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