Zafirlukast use while Breastfeeding
Drugs containing Zafirlukast: Accolate
Zafirlukast Levels and Effects while Breastfeeding
Summary of Use during Lactation
No published information is available on the use of zafirlukast during breastfeeding; however, manufacturer's data indicate that the dose in milk is low. If zafirlukast is required by the mother, it is not a reason to discontinue breastfeeding. Because there is no published experience with zafirlukast during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Zafirlukast has been used in children as young as 12 months of age.[1]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
The manufacturer reports that after administration of zafirlukast 40 mg twice daily to lactating women (number not reported), average steady-state milk concentrations were 50 mcg/L.[2] Using these data, a fully breastfed infant would be expected to receive about 0.6% of the maternal weight-adjusted dosage.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Beclomethasone, Cromolyn, Terbutaline, Theophylline
References
1. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10:149-59. PMID: 15701580
2. Anon. Accolate Package Insert. AstraZeneca Pharmaceuticals. Wilmington DE. July, 2004.
Zafirlukast Identification
Substance Name
CAS Registry Number
107753-78-6
Drug Class
- Anti-Asthmatic Agents
- Leukotriene Antagonists
Administrative Information
LactMed Record Number
601
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2007-12-27
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
See Also...
- Zafirlukast use during Pregnancy
- Zafirlukast Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy
Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.
