Xenon Xe 133 use while Breastfeeding

Drugs containing Xenon Xe 133: Xenon

Xenon Xe 133 Levels and Effects while Breastfeeding

Summary of Use during Lactation

Elective diagnostic nuclear medicine procedures should be delayed until the patient is no longer breastfeeding.[1] Information in this record refers to the use of xenon Xe 133 as a diagnostic agent. Because of its low systemic bioavailability after inhalation, the International Commission on Radiological Protection and other experts state breastfeeding need not be interrupted after administration of xenon Xe 133.[2][3]

Drug Levels

Xenon 133 is a beta emitter with a physical half-life of 5.24 days. Because of the poor solubility of xenon Xe 133, the amount that enters the venous circulation after inhalation is negligible. The small amount of xenon Xe 133 gas that passes into the venous circulation returns rapidly to the lungs to be exhaled.

Maternal Levels. Excretion of nonradioactive xenon in breastmilk was studied in 2 women who underwent about 1 hour of xenon anesthesia with a 65 to 69% inhaled xenon concentration. One mother consumed 8.3 L of xenon and the other had consumed 10 L during the procedure. Milk samples taken at 90 and 300 minutes after extubation contained no detectable xenon.[4]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

References

1. Parker JA, Daube-Witherspoon ME, Graham LS et al. Procedure guideline for general imaging: 3.0. Society of Nuclear Medicine. 2004. http://interactive.snm.org/docs/General_Imaging_v3.0.pdf

2. ICRP. Radiation dose to patients from radiopharmaceuticals. Addendum 3 to ICRP Publication 53. ICRP Publication 106. Annex D. Ann ICRP. 2008;38:163-84. PMID: 19154964

3. Stabin MG, Breitz HB. Breast milk excretion of radiopharmaceuticals: mechanisms, findings, and radiation dosimetry. J Nucl Med. 2000;41:863-73. PMID: 10809203

4. Stuttmann R, Schafer C, Hilbert P et al. The breast feeding mother and xenon anaesthesia: four case reports. Breast feeding and xenon anaesthesia. BMC Anesthesiol. 2010;10:1. PMID: 20167123

Xenon Xe 133 Identification

Substance Name

Xenon Xe 133

CAS Registry Number

14932-42-4

Drug Class

• Radiopharmaceuticals
• Xenon Radioisotopes

Administrative Information

LactMed Record Number

814

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2011-08-02

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