Terbutaline use while Breastfeeding
Drugs containing Terbutaline: Brethine, Bricanyl, Brethaire
Terbutaline Levels and Effects while Breastfeeding
Summary of Use during Lactation
Maternal use of oral or inhaled terbutaline is unlikely to affect a breastfed infant. The authors of several reviews and an expert panel agree that use of inhaled bronchodilators is acceptable during breastfeeding because of the low bioavailability and maternal serum levels after use.
Maternal Levels. With long-term maternal intake of 2.5 or 5 mg three times daily orally, milk terbutaline levels ranged from 2.5 to 4 mcg/L at various times during the dosing interval. There was little fluctuation of milk levels. The average dose that an exclusively breastfed infant would receive based on these patients is 1.4% (range 0.7 to 2.2%) of the maternal weight-adjusted dose.
Infant Levels. Serum levels were undetectable (<0.1 mcg/L) in one 8-week-old exclusively breastfed infant whose mother was taking oral terbutaline 5 mg three times daily.
Effects in Breastfed Infants
Two papers have reported a total of 4 infants aged 3 to 8 weeks who were breastfed during maternal use of oral terbutaline 2.5 or 5 mg three times daily. None of the infants had any signs of sympathetic stimulation and all were developing normally. These cases were also summarized in a third publication.
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
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CAS Registry Number
- Beta Adrenergic Agonists
LactMed Record Number
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
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