Rotavirus Vaccines use while Breastfeeding

Rotavirus Vaccines Levels and Effects while Breastfeeding

Summary of Use during Lactation

Rotavirus vaccines are used only in infants and are not indicated for use in women of childbearing age. Breastfeeding protects infants against acute gastroenteritis caused by rotavirus.[1] However, breastfeeding can reduce the immune response of an infant to rotavirus vaccines.[2][3][4][5][6] The extent of the effect depends on the maternal anti-rotavirus antibody titer in breastmilk with higher titers found in less developed countries.[7][8] However, a study in Indonesia found that rotavirus vaccine was cost-effective for the health system, even with improved breastfeeding rates.[9] A European study found no difference in rotavirus infection rates during the first season between infants who were breastfed and formula-fed when they received rotavirus vaccination. In the second season, protection against infection was slightly less in breastfed infants.[5] A German study found that exclusive or partial breastfeeding increased the risk of breakthrough infection fourfold.[6] Withholding breastfeeding for up to 2 hours before and after vaccine administration has been recommended to minimize the interference;[7][10] however, a South African study found that withholding breastfeeding for one hour before and after immunization had no effect on the seroconversion rate.[11]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

A subset of 300 infants in a multicenter European rotavirus efficacy trial had antirotavirus IgA titers measured 1 to 2 months after the second rotavirus dose (Rotarix - GSK). Breast-fed infants had an 85.5 % conversion rate compared with 89.2 % rate in exclusively formula-fed infants, which was not statistically different. The serum antirotavirus IgA concentrations were 185.8 units/mL and 231.5 units/mL in the breastfed and exclusively formula-fed infants, respectively.[5]

Two hundred fifty breastfed infants were randomized to receive their routine rotavirus vaccination (Rotarix) with either unrestricted breastfeeding or withholding breastfeeding from 1 hour before to 1 hour after the vaccination. No difference were found in the rate of seroconversion between the two groups of infants.[11]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1. Plenge-Bonig A, Soto-Ramirez N, Karmaus W et al. Breastfeeding protects against acute gastroenteritis due to rotavirus in infants. Eur J Pediatr. 2010;169:1471-6. PMID: 20617343

2. Goveia MG, Dinubile MJ, Dallas MJ, Heaton PM, Kuter BJ. Efficacy of pentavalent human-bovine (WC3) reassortant rotavirus vaccine based on breastfeeding frequency. Pediatr Infect Dis J. 2008;27:656-8. PMID: 18520448

3. Rennels MB. Influence of breast-feeding and oral polio vaccine on the immunogenicity and efficacy of rotavirus vaccines. J Infect Dis. 1996;174 (Suppl 1):S107-11. PMID: 8752299

4. Pichichero ME. Effect of breast-feeding on oral rhesus rotavirus vaccine seroconversion: a metaanalysis. J Infect Dis. 1990;162:753-5. PMID: 2167344

5. Vesikari T, Prymula R, Schuster V et al. Efficacy and immunogenicity of live-attenuated human rotavirus vaccine in breast-fed and formula-fed European infants. Pediatr Infect Dis J. 2012;31:509-13. PMID: 22228235

6. Adlhoch C, Hoehne M, Littmann M et al. Rotavirus vaccine effectiveness and case-control study on risk factors for breakthrough infections in Germany, 2010-2011. Pediatr Infect Dis J. 2013;32:e82-9. PMID: 23334342

7. Moon SS, Wang Y, Shane AL et al. Inhibitory effect of breast milk on infectivity of live oral rotavirus vaccines. Pediatr Infect Dis J. 2010;29:919-23. PMID: 20442687

8. Chan J, Nirwati H, Triasih R et al. Maternal antibodies to rotavirus: Could they interfere with live rotavirus vaccines in developing countries? Vaccine. 2011;29:1242-7. PMID: 21147127

9. Suwantika AA, Postma MJ. Effect of breastfeeding promotion interventions on cost-effectiveness of rotavirus immunization in Indonesia. BMC Public Health. 2013;13:1106. PMID: 24289227

10. Foster RH, Wagstaff AJ. Tetravalent human-rhesus reassortant rotavirus vaccine: a review of its immunogenicity, tolerability and protective efficacy against paediatric rotavirus gastroenteritis. BioDrugs. 1998;9:155-78. PMID: 18020551

11. Groome MJ, Moon SS, Velasquez D et al. Effect of breastfeeding on immunogenicity of oral live-attenuated human rotavirus vaccine: a randomized trial in HIV-uninfected infants in Soweto, South Africa. Bull World Health Organ. 2014;92:238-45. PMID: 24700991

Rotavirus Vaccines Identification

Substance Name

Rotavirus Vaccines

Drug Class

Vaccines

Viral Vaccines

Administrative Information

LactMed Record Number

733

Last Revision Date

20140515

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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