Pyrethrins use while Breastfeeding

Drugs containing Pyrethrins: RID, A-200 Lice Treatment, Lice Treatment, Rid Shampoo/Spray Kit, Pronto Lice Kill System, A-200 Lice Control, Licide, Rid Pediculicide, Good Sense Lice Killing Shampoo, Step 1, Pronto Shampoo Kit, Show all 33 »Triple X Pediculicide, Pyrinyl Liquid Shampoo, Pyrinyl Liquid, Pronto with Metal Comb, Rid Pediculicide Spray, Pronto Shampoo & Cream Rinse, Pronto Spray, Tisit, Lice Treatment Maximum Strength, Pyrinil Lice Control Kit, Leader Lice Solution, Tegrin-LT Lice Treatment Kit, Pyrinyl II, R & C, Complete Lice Treatment Kit, RID Complete Kit, Lice-X Liquid, R & C Lice Treatment Spray, End Lice Liquid, Tegrin-LT Shampoo, R & C Lice Treatment Kit, Lice Solution, Tegrin-LT Lice Spray

Pyrethrins Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because absorption after topical application is very limited, occasional pyrethrins and piperonyl butoxide use is acceptable in nursing mothers. This combination is recommended by the Centers for Disease Control and Prevention for the treatment of lice infestations during lactation.[1] Extensive exposure, such as from agricultural use or malaria control might have long-term health concerns because residues can be found in breastmilk.[2] Only water-miscible cream, gel or liquid products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[3]

Drug Levels

Maternal Levels. Pyrethrins were measured in 53 breastmilk samples from 29 mothers collected 1998 to 1999 in Basel Switzerland. Pyrethrins were detected in 42 milk samples, even in mothers from households that reported no pyrethrin use. The average pyrethrins concentration was 89 mcg/kg of fat (range undetectable [<25 mcg/kg] to 341 mcg/kg fat).[4]

Pyrethroids (permethrin, cyfluthrin, cypermethrin and deltamethrin) were found in the breastmilk of nursing mothers in 3 South African towns. Average levels in breastmilk ranged from 8.3 to 48.4 mcg/L in the 3 towns. The source was thought to be from a dusting powder widely available and used in gardening. The dosage and route of exposure (i.e., topical, inhalation, oral) could not be determined. All milk levels were below the allowable daily limit for permethrin.[5][6]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Permethrin

References

1. Workowski KA, Berman S. Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. 2010;59 (RR-12):1-110. PMID: 21160459

2. Bouwman H, Kylin H. Malaria control insecticide residues in breast milk: the need to consider infant health risks. Environ Health Perspect. 2009;117:1477-80. PMID: 20019894

3. Noti A, Grob K, Biedermann M et al. Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38:317-25. PMID: 14623482

4. Zehringer M , Herrmann A. Analysis of polychlorinated biphenyls, pyrethroid insecticides and fragrances in human milk using a laminar cup liner in the GC injector. Eur Food Res Technol. 2001;212:247-51.

5. Sereda B, Bouwman H, Kylin H. Comparing water, bovine milk, and indoor residual spraying as possible sources of DDT and pyrethroid residues in breast milk. J Toxicol Environ Health A. 2009;72:842-51. PMID: 19557612

6. Bouwman H, Sereda B, Meinhardt HM. Simultaneous presence of DDT and pyrethroid residues in human breast milk from a malaria endemic area in South Africa. Environ Pollut. 2006;144:902-17. PMID: 16564119

Pyrethrins Identification

Substance Name

Pyrethrins

CAS Registry Number

8003-34-7

Drug Class

Antiinfective Agents

Antiparasitic Agents

Insecticides

Administrative Information

LactMed Record Number

734

Last Revision Date

20140116

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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