Because there is no published experience with pimozide during breastfeeding, other drugs are preferred.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Pimozide can cause hyperprolactinemia.[1,2] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[3]
Delitala G, Masala A, Alagna S. Suppression of pimozide-induced prolaction secretion by piridoxine (vitamin B6). Biomedicine. 1977;27:190–2. [PubMed: 562688]
2.
Fiore L, Scapagnini U, Canonico PL. Effect of dihydroergocryptine and dihydroergocristine on cyclic AMP accumulation and prolactin release in vitro: Evidence for a dopaminomimetic action. Horm Res. 1987;25:171–7. [PubMed: 3032757]
3.
Maguire GA. Prolactin elevation with antipsychotic medications: Mechanisms of action and clinical consequences. J Clin Psychiatry. 2002;63 Suppl 4:56–62. [PubMed: 11913677]
Substance Identification
Substance Name
Pimozide
CAS Registry Number
2062-78-4
Drug Class
Breast Feeding
Lactation
Milk, Human
Antipsychotic Agents
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