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Methscopolamine Bromide use while Breastfeeding

Drugs containing Methscopolamine Bromide: Pamine, Pamine Forte, AlleRx Dose Pack, Triall, ScopoHist, QV-Allergy, Nacon, PCM, Sinodec, DryMax, Show all 119 »Amdry-C, Pannaz, Coldamine, Dexodryl Suspension, AllePak, Dexodryl, Dallergy PSE, DriHist, RelCof DN PSE, Rhinolar, Extendryl JR, DuraHist, Xiral SR, PCM Allergy, Extendryl Seniors, Rescon Extended Release, Dallergy ER, Aerokid, Denaze, AlleRx Dose Pack PE (PM Dose), Redur-PCM, Relcof PSE, Chlor-Mes, Histatab PH, Ah-chew Ultra, Re-Drylex Jr, Allergy DN, Pamine FQ, AlleRx Dose Pack PE (AM Dose), Histatab D, DuraHist D, D-Hist D, Extendryl PEM, Sudatrate, Respivent-D, Allerx-D, Extendryl PSE, Amdry-D, AlleRx Dose Pack (AM Dose), Extendryl, DexPhen M, Rhinaclear, Ralix, Time-Hist QD, PCM-LA, Hista-Vent PSE, Pseudo CM TR, Allergy AM-PM Dose Pack, Re-Drylex, CoryZa-D, Histatab, VisRx Dose Pack, Mescolor, Chlor-Mes D, RelCof DN PE, RelCof PE, Nohist PE, DriHist SR, Dehistine, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), Nohist Plus Jr, Dallergy SR, Nohist Plus, DuraTan PE, Allergy DN PE, Duravent, Ryneze, Extendryl DM, SymPak, SymPak DM, Pseudox M, Pannaz S, RelCof CPM, AlleRx DF, aeroHist, Allerx Dose Pack DF, RespiVent DF, NoHist EXT, Allergy DN II, Duradryl Chewable, Aerohist Plus, Duradryl JR, Drize, Duradryl, AH-Chew, Liqui-Allergy, Drysec, Ex-Histine, Durahist PE, Omnihist II LA, Norel SD, SymPak II, WE Allergy, DA II, Hista-Vent DA, Ah-Chew Ultra Tannate, SymPak PDX, CPM-PE-MSC, Dallergy PE, Duradryl SR, ScopoHist-PE, Extendryl SR, Omnihist L.A., Duravent DA, DA Chewable, Extendryl Chews, Prehist D, AH-Chew II

Methscopolamine Bromide Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the use of methscopolamine bromide during breastfeeding. Because methscopolamine bromide is a quaternary ammonium compound, it is not likely to be absorbed and reach the bloodstream of the infant. Long-term use of methscopolamine bromide might reduce milk production or milk letdown, but a single dose is unlikely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).

To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date. br>

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information in nursing mothers was not found as of the revision date. Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion.[1][2][3][4][5] Anticholinergic drugs can also reduce serum prolactin in nonnursing women.[6] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

References

1. Aaron DK, Ely DG, Deweese WP et al. Reducing milk production in ewes at weaning using restricted feeding and methscopolamine bromide. J Anim Sci. 1997;75:1434-42. PMID: 9250502

2. Powell MR, Keisler DH. A potential strategy for decreasing milk production in the ewe at weaning using a growth hormone release blocker. J Anim Sci. 1995;73:1901-5. PMID: 7592071

3. Daniel JA, Thomas MG, Powell MR, Keisler DH. Methscopolamine bromide blocks hypothalmic-stimulated release of growth hormone in ewes. J Anim Sci. 1997;75:1359-62. PMID: 9159285

4. Bizzarro A, Iannucci F, Tolino A et al. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980;7:108-11. PMID: 6788407

5. Svennersten K, Nelson L, Juvnas-Moberg K. Atropinization decreases oxytocin secretion in dairy cows. Acta Physiol Scand. 1992;145:193-4. PMID: 1636447

6. Masala A, Alagna S, Devilla L et al. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982;5:53-5. PMID: 6808052

Methscopolamine Bromide Identification

Substance Name

Methscopolamine Bromide

CAS Registry Number

13265-10-6

Drug Class

Muscarinic Antagonists

Parasympatholytics

Administrative Information

LactMed Record Number

765

Last Revision Date

20150310

Disclaimer

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