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Methscopolamine Bromide use while Breastfeeding

Drugs containing Methscopolamine Bromide: Pamine, Pamine Forte, PCM, Triall, Mescolor, Prehist D, PCM Allergy, RespiVent DF, VisRx Dose Pack, Duravent, Show all 119 »Extendryl Chews, Extendryl, DriHist, Relcof PSE, Xiral SR, RelCof DN PSE, DuraHist, DryMax, Rhinolar, Dallergy PSE, AlleRx Dose Pack, Extendryl JR, Extendryl Seniors, QV-Allergy, Dallergy ER, Aerokid, Ralix, Denaze, Rescon Extended Release, AlleRx Dose Pack PE (PM Dose), Chlor-Mes, Re-Drylex Jr, Histatab PH, Ah-chew Ultra, Redur-PCM, Hista-Vent PSE, Allergy DN, Pamine FQ, AlleRx Dose Pack PE (AM Dose), Histatab D, DuraHist D, D-Hist D, Extendryl PEM, Sudatrate, Respivent-D, Allerx-D, Extendryl PSE, Amdry-D, AlleRx Dose Pack (AM Dose), DexPhen M, Re-Drylex, Rhinaclear, AH-Chew II, AllePak, Time-Hist QD, Amdry-C, Pseudo CM TR, Coldamine, CoryZa-D, Histatab, Allergy AM-PM Dose Pack, ScopoHist, PCM-LA, Chlor-Mes D, DriHist SR, Nohist PE, Dehistine, Ryneze, Dexodryl, RelCof DN PE, RelCof PE, DuraTan PE, Nohist Plus, Allergy DN PE, AlleRx Dose Pack (PM Dose), ScopoHist Syrup, Dexodryl Suspension, Allerx Dose Pack DF, Pannaz, SymPak DM, Nacon, Pseudox M, Pannaz S, Extendryl DM, SymPak, NoHist EXT, aeroHist, Allergy DN II, AlleRx DF, RelCof CPM, Nohist Plus Jr, Dallergy SR, Duradryl, Duradryl JR, AH-Chew, Liqui-Allergy, DA II, Drize, Drysec, Norel SD, Durahist PE, SymPak II, WE Allergy, Ex-Histine, Hista-Vent DA, Duravent DA, Dallergy PE, CPM-PE-MSC, Duradryl SR, Aerohist Plus, Duradryl Chewable, Ah-Chew Ultra Tannate, SymPak PDX, DA Chewable, Omnihist L.A., Extendryl SR, Sinodec, ScopoHist-PE, Omnihist II LA

Methscopolamine Bromide Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the use of methscopolamine bromide during breastfeeding. Because methscopolamine bromide is a quaternary ammonium compound, it is not likely to be absorbed and reach the bloodstream of the infant. Long-term use of methscopolamine bromide might reduce milk production or milk letdown, but a single dose is unlikely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).

To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date. br>

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information in nursing mothers was not found as of the revision date. Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion.[1][2][3][4][5] Anticholinergic drugs can also reduce serum prolactin in nonnursing women.[6] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

References

1. Aaron DK, Ely DG, Deweese WP et al. Reducing milk production in ewes at weaning using restricted feeding and methscopolamine bromide. J Anim Sci. 1997;75:1434-42. PMID: 9250502

2. Powell MR, Keisler DH. A potential strategy for decreasing milk production in the ewe at weaning using a growth hormone release blocker. J Anim Sci. 1995;73:1901-5. PMID: 7592071

3. Daniel JA, Thomas MG, Powell MR, Keisler DH. Methscopolamine bromide blocks hypothalmic-stimulated release of growth hormone in ewes. J Anim Sci. 1997;75:1359-62. PMID: 9159285

4. Bizzarro A, Iannucci F, Tolino A et al. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980;7:108-11. PMID: 6788407

5. Svennersten K, Nelson L, Juvnas-Moberg K. Atropinization decreases oxytocin secretion in dairy cows. Acta Physiol Scand. 1992;145:193-4. PMID: 1636447

6. Masala A, Alagna S, Devilla L et al. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982;5:53-5. PMID: 6808052

Methscopolamine Bromide Identification

Substance Name

Methscopolamine Bromide

CAS Registry Number

13265-10-6

Drug Class

Muscarinic Antagonists

Parasympatholytics

Administrative Information

LactMed Record Number

765

Last Revision Date

20150310

Disclaimer

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