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Methscopolamine Bromide use while Breastfeeding

Drugs containing Methscopolamine Bromide: Pamine, Denaze, DryMax, PCM, Ralix, Pamine Forte, Rhinaclear, Dehistine, Dexodryl Suspension, D-Hist D, Show all 119 »aeroHist, Pannaz, AH-Chew II, Rhinolar, AlleRx Dose Pack, DriHist, DuraHist, Xiral SR, Mescolor, Relcof PSE, Dallergy PSE, RelCof DN PSE, Extendryl JR, PCM Allergy, Histatab PH, Chlor-Mes, Ah-chew Ultra, Rescon Extended Release, Redur-PCM, Hista-Vent PSE, QV-Allergy, AlleRx Dose Pack PE (PM Dose), Aerokid, Dallergy ER, Extendryl Seniors, Re-Drylex Jr, Pseudo CM TR, Pamine FQ, AlleRx Dose Pack PE (AM Dose), Histatab D, DuraHist D, Extendryl, Extendryl PEM, Sudatrate, Respivent-D, Allerx-D, Extendryl PSE, Amdry-D, AlleRx Dose Pack (AM Dose), DexPhen M, Re-Drylex, Allergy DN, Omnihist II LA, AllePak, Time-Hist QD, Amdry-C, Coldamine, ScopoHist, CoryZa-D, Histatab, VisRx Dose Pack, Allergy AM-PM Dose Pack, PCM-LA, WE Allergy, RelCof DN PE, RelCof PE, Nohist PE, DriHist SR, Duravent, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), Nohist Plus Jr, Dallergy SR, Nohist Plus, DuraTan PE, Allergy DN PE, Ryneze, Dexodryl, SymPak DM, Extendryl DM, Nacon, Pseudox M, Pannaz S, SymPak, RelCof CPM, RespiVent DF, Allerx Dose Pack DF, NoHist EXT, Allergy DN II, AlleRx DF, Duradryl Chewable, Aerohist Plus, AH-Chew, Duradryl, Liqui-Allergy, DA II, Hista-Vent DA, Duradryl JR, Drize, Chlor-Mes D, Norel SD, SymPak II, Ex-Histine, Drysec, Duravent DA, Omnihist L.A., Ah-Chew Ultra Tannate, Triall, CPM-PE-MSC, Dallergy PE, Duradryl SR, SymPak PDX, ScopoHist-PE, Extendryl Chews, DA Chewable, Prehist D, Extendryl SR, Sinodec, Durahist PE

Methscopolamine Bromide Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the use of methscopolamine bromide during breastfeeding. Because methscopolamine bromide is a quaternary ammonium compound, it is not likely to be absorbed and reach the bloodstream of the infant. Long-term use of methscopolamine bromide might reduce milk production or milk letdown, but a single dose is unlikely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).

To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information in nursing mothers was not found as of the revision date. Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion.[1][2][3][4][5] Anticholinergic drugs can also reduce serum prolactin in nonnursing women.[6] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

References

1. Aaron DK, Ely DG, Deweese WP et al. Reducing milk production in ewes at weaning using restricted feeding and methscopolamine bromide. J Anim Sci. 1997;75:1434-42. PMID: 9250502

2. Powell MR, Keisler DH. A potential strategy for decreasing milk production in the ewe at weaning using a growth hormone release blocker. J Anim Sci. 1995;73:1901-5. PMID: 7592071

3. Daniel JA, Thomas MG, Powell MR, Keisler DH. Methscopolamine bromide blocks hypothalmic-stimulated release of growth hormone in ewes. J Anim Sci. 1997;75:1359-62. PMID: 9159285

4. Bizzarro A, Iannucci F, Tolino A et al. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980;7:108-11. PMID: 6788407

5. Svennersten K, Nelson L, Juvnas-Moberg K. Atropinization decreases oxytocin secretion in dairy cows. Acta Physiol Scand. 1992;145:193-4. PMID: 1636447

6. Masala A, Alagna S, Devilla L et al. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982;5:53-5. PMID: 6808052

Methscopolamine Bromide Identification

Substance Name

Methscopolamine Bromide

CAS Registry Number

13265-10-6

Drug Class

Muscarinic Antagonists

Parasympatholytics

Administrative Information

LactMed Record Number

765

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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