Methscopolamine Bromide use while Breastfeeding
Drugs containing Methscopolamine Bromide: PCM, Extendryl, DuraHist D, Pamine, Pamine Forte, Nacon, CPM-PE-MSC, Ah-chew Ultra, Rescon Extended Release, Coldamine, Show all 119 »PCM-LA, Pannaz, Dexodryl Suspension, RelCof DN PSE, Dallergy PSE, Relcof PSE, Xiral SR, DriHist, DryMax, Rhinolar, AlleRx Dose Pack, Extendryl JR, DuraHist, Mescolor, Aerokid, Dallergy ER, Denaze, Ralix, AH-Chew II, Extendryl Seniors, QV-Allergy, Chlor-Mes, PCM Allergy, Histatab PH, Redur-PCM, AlleRx Dose Pack PE (PM Dose), Re-Drylex Jr, Allergy DN, AlleRx Dose Pack PE (AM Dose), Extendryl PEM, Pamine FQ, Histatab D, D-Hist D, Sudatrate, AlleRx Dose Pack (AM Dose), Allerx-D, Respivent-D, Extendryl PSE, Amdry-D, DexPhen M, Re-Drylex, Rhinaclear, Omnihist II LA, AllePak, Time-Hist QD, Amdry-C, Pseudo CM TR, ScopoHist, CoryZa-D, Histatab, VisRx Dose Pack, Allergy AM-PM Dose Pack, Hista-Vent PSE, WE Allergy, Nohist PE, RelCof DN PE, DriHist SR, Dehistine, Duravent, RelCof PE, ScopoHist Syrup, Nohist Plus, Nohist Plus Jr, DuraTan PE, Allergy DN PE, AlleRx Dose Pack (PM Dose), Ryneze, Dexodryl, Extendryl DM, SymPak, SymPak DM, Pseudox M, Pannaz S, RelCof CPM, AlleRx DF, aeroHist, Allerx Dose Pack DF, RespiVent DF, NoHist EXT, Allergy DN II, Dallergy SR, Duradryl Chewable, AH-Chew, Duradryl, Liqui-Allergy, DA II, Hista-Vent DA, Duradryl JR, Drize, Chlor-Mes D, Norel SD, SymPak II, Ex-Histine, Drysec, Duravent DA, Omnihist L.A., Ah-Chew Ultra Tannate, Triall, Dallergy PE, Duradryl SR, Aerohist Plus, SymPak PDX, ScopoHist-PE, Extendryl Chews, DA Chewable, Prehist D, Extendryl SR, Sinodec, Durahist PE
Methscopolamine Bromide Levels and Effects while Breastfeeding
Summary of Use during Lactation
No information is available on the use of methscopolamine bromide during breastfeeding. Because methscopolamine bromide is a quaternary ammonium compound, it is not likely to be absorbed and reach the bloodstream of the infant. Long-term use of methscopolamine bromide might reduce milk production or milk letdown, but a single dose is unlikely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).
To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.
Maternal Levels. Relevant published information was not found as of the revision date. br>
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information in nursing mothers was not found as of the revision date. Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion. Anticholinergic drugs can also reduce serum prolactin in nonnursing women. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
1. Aaron DK, Ely DG, Deweese WP et al. Reducing milk production in ewes at weaning using restricted feeding and methscopolamine bromide. J Anim Sci. 1997;75:1434-42. PMID: 9250502
2. Powell MR, Keisler DH. A potential strategy for decreasing milk production in the ewe at weaning using a growth hormone release blocker. J Anim Sci. 1995;73:1901-5. PMID: 7592071
3. Daniel JA, Thomas MG, Powell MR, Keisler DH. Methscopolamine bromide blocks hypothalmic-stimulated release of growth hormone in ewes. J Anim Sci. 1997;75:1359-62. PMID: 9159285
4. Bizzarro A, Iannucci F, Tolino A et al. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980;7:108-11. PMID: 6788407
5. Svennersten K, Nelson L, Juvnas-Moberg K. Atropinization decreases oxytocin secretion in dairy cows. Acta Physiol Scand. 1992;145:193-4. PMID: 1636447
6. Masala A, Alagna S, Devilla L et al. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982;5:53-5. PMID: 6808052
Methscopolamine Bromide Identification
CAS Registry Number
LactMed Record Number
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.