Magnesium Citrate use while Breastfeeding

Drugs containing Magnesium Citrate: Citroma, Citrate of Magnesia, LiquiPrep, LoSo Prep Bowel Cleansing System, Dulcolax Bowel Cleansing, Tridate, Evac-Q-Kwik, Royvac Bowel Evacuant

Magnesium Citrate Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the clinical use of magnesium citrate during breastfeeding. However, other magnesium salts have been studied. Intravenous magnesium sulfate increases milk magnesium concentrations only slightly. Oral absorption of magnesium by the infant is poor, so maternal magnesium citrate is not expected to affect the breastfed infant's serum magnesium. Magnesium citrate can be taken during breastfeeding and no special precautions are required.

Drug Levels

Maternal Levels. Ten women with pre-eclampsia were given 4 grams of magnesium sulfate intravenously followed by 1 gram per hour until 24 hours after delivery. While the average serum magnesium was 35.5 mg/L in treated women compared to 18.2 mg/L in 5 untreated controls, colostrum magnesium levels at the time of discontinuation of the infusion was 64 mg/L in treated women and 48 mg/L in the controls. By 48 hours after discontinuation, colostrum magnesium levels were only slightly above control values and by 72 hours they were virtually identical to controls.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Fifty mothers who were in the first day postpartum received 15 mL of either mineral oil or an emulsion of mineral oil and another magnesium salt, magnesium hydroxide equivalent to 900 mg of magnesium hydroxide, although the exact number who received each product was not stated. Additional doses were given on subsequent days if needed. None of the breastfed infants were noted to have any markedly abnormal stools, but all of the infants also received supplemental feedings.[2]

Possible Effects on Lactation

One mother who received intravenous magnesium sulfate for 3 days for pregnancy-induced hypertension had lactogenesis II delayed until day 10 postpartum. No other specific cause was found for the delay, although a complete work-up was not done.[3] A subsequent controlled clinical trial found no evidence of delayed lactation in mothers who received intravenous magnesium sulfate therapy.[4] Some, but not all, studies have found a trend toward increased time to the first feeding or decreased sucking in infants of mothers treated with intravenous magnesium sulfate during labor because of placental transfer of magnesium to the fetus.[4][5]

Alternate Drugs to Consider

(Laxative) Bisacodyl, Docusate, Magnesium Hydroxide, Psyllium, Sodium Picosulfate, Sodium Phosphate

References

1. Cruikshank DP, Varner MW, Pitkin RM. Breast milk magnesium and calcium concentrations following magnesium sulfate treatment. Am J Obstet Gynecol. 1982;143:685-8. PMID: 7091241

2. Baldwin WF. Clinical study of senna administration to nursing mothers.:assessment of effects on infant bowel habits. Can Med Assoc J. 1963;89:566-7. PMID: 14045350

3. Haldeman W. Can magnesium sulfate therapy impact lactogenesis? J Hum Lact. 1993;9:249-52. PMID: 8260059

4. Riaz M, Porat R, Brodsky NL, Hurt H. The effects of maternal magnesium sulfate treatment on newborns: a prospective controlled study. J Perinatol. 1998;18:449-54. PMID: 9848759

5. Rasch DK, Huber PA, Richardson CJ et al . Neurobehavioral effects of neonatal hypermagnesemia. J Pediatr. 1982;100:272-6. PMID: 7199083

Magnesium Citrate Identification

Substance Name

Magnesium Citrate

CAS Registry Number

3344-18-1

Drug Class

Administrative Information

LactMed Record Number

1007

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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