Loperamide use while Breastfeeding

Drugs containing Loperamide: Imodium, Imodium A-D, Anti-Diarrheal, Imodium Multi-Symptom Relief, Diamode, Imotil, Up and Up Anti-Diarrheal Solution, Kaopectate 1-D, Neo-Diaral, Kaopectate II, Show all 13 »Diar-Aid, Kao-Paverin, Pepto Diarrhea Control

Loperamide Levels and Effects while Breastfeeding

Summary of Use during Lactation

Use of loperamide during breastfeeding is unlikely to affect the infant.

Drug Levels

Maternal Levels. Loperamide has not been studied during breastfeeding, but the loperamide prodrug, loperamide oxide, has been studied in a dosage of 2 doses of 4 mg given 12 hours apart to 6 women 18 to 47 hours after delivery. Median loperamide milk concentrations were 0.18 mcg/L at 12 hours after the first dose, 0.27 mcg/L at 6 hours after the second dose, and 0.19 mcg/L at 24 hours after the second dose.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

References

1. Nikodem VC, Hofmeyr GJ. Secretion of the antidiarrhoeal agent loperamide oxide in breast milk. Eur J Clin Pharmacol. 1992;42:695-6. PMID: 1623917

Loperamide Identification

Substance Name

Loperamide

CAS Registry Number

53179-11-6

Drug Class

Administrative Information

LactMed Record Number

424

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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