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Lansoprazole use while Breastfeeding

Drugs containing Lansoprazole: Prevacid, Prevpac, Prevacid SoluTab, Prevacid OTC, Prevacid 24HR, Prevacid NapraPAC 375, Prevacid NapraPAC, Prevacid NapraPAC 500, Prevacid IV

Lansoprazole Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because no information is available on the use of lansoprazole during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

One case of elevated serum prolactin and galactorrhea was reported in a 21-year-old man. When omeprazole was substituted for lansoprazole, the serum prolactin decreased to the normal range and galactorrhea ceased.[1]

A 13-year-old girl with a recent history of bilateral galactorrhea and hyperprolactinemia from omeprazole and domperidone on separate occasions was given lansoprazole to prevent gastrointestinal irritation following intravenous diclofenac for a severe headache. After 3 days of lansoprazole therapy, she again developed galactorrhea and an elevated serum prolactin that returned to normal a week after discontinuing lansoprazole.[2]

Alternate Drugs to Consider

Cimetidine, Famotidine, Nizatidine, Omeprazole, Pantoprazole, Ranitidine, Sucralfate

References

1. Izquierdo Prieto OM, Moreno Alia E, Rosillo Gonzalez A. [Galactorrhea induced by lansoprazole]. Aten Primaria. 2004;34:325-6. PMID: 15491529

2. Jabbar A, Khan R, Farrukh SN. Hyperprolactinaemia induced by proton pump inhibitor. J Pak Med Assoc. 2010;60:689-90. PMID: 20726208

Lansoprazole Identification

Substance Name

Lansoprazole

CAS Registry Number

103577-45-3

Drug Class

Anti-Ulcer Agents

Administrative Information

LactMed Record Number

411

Last Revision Date

20130907

Disclaimer

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