Iodofiltic Acid I 123 use while Breastfeeding

Iodofiltic Acid I 123 Levels and Effects while Breastfeeding

Summary of Use during Lactation

Information in this record refers to the use of iodofiltic acid I 123 (beta-methyl-15-(4-iodophenyl) pentadecanoic acid; I 123 BMIPP) as a diagnostic agent. The International Commission on Radiological Protection states that breastfeeding should be interrupted for more than 3 weeks following diagnostic use of I 123 BMIPP. This usually will result in permanent discontinuation of breastfeeding for this infant.

Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at a safe level she may resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.[1]

Drug Levels

I 123 is a gamma emitter with a principal photon energy of 159 keV and a physical half-life of 13.2 hours.[2] Iodide is actively secreted into breastmilk and actively taken up by the mother's and infant's thyroid glands.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1. ICRP. Radiation dose to patients from radiopharmaceuticals. Addendum 3 to ICRP Publication 53. ICRP Publication 106. Annex D. Ann ICRP. 2008;38:163-84. PMID: 19154964

2. Howe DB, Beardsley M, Bakhsh S. Appendix U. Model procedure for release of patients or human research subjects administered radioactive materials. In, NUREG-1556. Consolidated guidance about materials licenses. Program-specific guidance about medical use licenses. Final report. U.S. Nuclear Regulatory Commission Office of Nuclear Material Safety and Safeguards. 2008;9, Rev. 2. http://www.nrc.gov/reading-rm/doc-collections/nuregs/staff/sr1556/v9/r2/

Iodofiltic Acid I 123 Identification

Substance Name

Iodofiltic Acid I 123

CAS Registry Number

123748-56-1

Drug Class

Radiopharmaceuticals

Iodine Radioisotopes

Administrative Information

LactMed Record Number

808

Last Revision Date

20141107

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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