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Diltiazem use while Breastfeeding

Drugs containing Diltiazem: Cardizem, Cartia XT, Cardizem CD, Tiazac, Diltiazem Hydrochloride CD, Taztia XT, Cardizem LA, Diltia XT, Matzim LA, Cardizem SR, Show all 18 »Diltiazem Hydrochloride XR, Diltiazem Hydrochloride SR, Dilt-XR, Dilacor XR, Teczem, Diltzac, Diltiazem Hydrochloride XT, Cardizem Monovial

Diltiazem Levels and Effects while Breastfeeding

Summary of Use during Lactation

Based on limited data, amounts of diltiazem ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.

Drug Levels

Maternal Levels. In one patient who was 14 days postpartum, peak milk levels of 190 to 230 mcg/L occurred about 2 hours after the dose during an oral regimen of 60 mg four times daily. The levels and time course of the drug in milk closely paralleled serum levels.[1] Using the peak milk level data from this patient, an exclusively breastfed infant would receive an estimated maximum of 0.9% of the maternal weight-adjusted dosage.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Nifedipine, Verapamil

References

1. Okada M, Inoue H, Nakamura Y et al. Excretion of diltiazem in human milk. N Engl J Med. 1985;312:992-3. PMID: 3974691

Diltiazem Identification

Substance Name

Diltiazem

CAS Registry Number

42399-41-7

Drug Class

  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Antiarrhythmics
  • Vasodilator Agents

Administrative Information

LactMed Record Number

94

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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