Dexbrompheniramine use while Breastfeeding
Drugs containing Dexbrompheniramine: Drixoral, Chlo Tuss, Histussin HC Syrup, Conex, Dologen, M-End DMX, Ala-Hist IR, Dixaphedrine, Disophrol, Dexall, Show all 41 »M-End Max D, Drixoral Cold and Allergy, Drexophed SR, Desihist SA, Complete Sinus Relief, Duomine, Drixoral Cold/Flu, Disobrom, Pharmadrine, Poly Tan, Drixomed, Dexaphen SA, Poly Tan D, 12 Hour Cold, Dexophed, H-C Tussive-NR, Tussall-ER, Panatuss DXP, Tussall, Y-Cof DM, Drixoral Cold and Flu, Deka, Panatuss Pediatric DXP, Supress A, Cytuss-HC NR, Drixoral Sinus, Sinadrin Plus, Drixoral Allergy Sinus, Supress A Pediatric, Poly Tan DM, Ala-Hist PE
Dexbrompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of dexbrompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Possible Effects on Lactation
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
CAS Registry Number
LactMed Record Number
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
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