Dexbrompheniramine use while Breastfeeding
Drugs containing Dexbrompheniramine: Dologen, M-End DMX, Chlo Tuss, Panatuss Pediatric DXP, Drixoral, Histussin HC Syrup, Ala-Hist PE, Conex, Disophrol, Chlo Tuss (old formulation), Show all 46 »Disobrom, Tussall, Ala-Hist IR, Dologen 325, Pharmadrine, Drixoral Cold and Allergy, Poly Tan D, Dixaphedrine, Poly Tan, Drixomed, Dexaphen SA, Duomine, Desihist SA, Dexophed, Drexophed SR, 12 Hour Cold, H-C Tussive-NR, Tussall-ER, Drixoral Cold and Flu, Drixoral Sinus, Chlo Hist, Drixoral Allergy Sinus, Sinadrin Plus, G-Dologen, Drixoral Cold/Flu, Complete Sinus Relief, M-End Max D, Deka, Panatuss DXP, Supress A Pediatric, Poly Tan DM, Supress A, Y-Cof DM, Dexall, G-P-Tuss DXP, Cytuss-HC NR
Dexbrompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of dexbrompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
CAS Registry Number
LactMed Record Number
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.