Chlorpropamide use while Breastfeeding

Drugs containing Chlorpropamide: Diabinese

Chlorpropamide Levels and Effects while Breastfeeding

Summary of Use during Lactation

It appears that amounts of chlorpropamide in breastmilk are unlikely to affect a breastfed infant. Short-acting drugs are generally preferred while breastfeeding a neonate to avoid drug accumulation. Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]

Drug Levels

Maternal Levels. No studies on the excretion of chlorpropamide into breastmilk have been published. The manufacturer states that a level of 5 mg/L was found in breastmilk 5 hours after a 500 mg dose; however, no study details were given.[1][3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Acarbose, Glyburide, Insulin, Metformin, Tolbutamide

References

1. Everett JA. Use of oral antidiabetic agents during breastfeeding. J Hum Lact. 1997;13:319-21. PMID: 9429368

2. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10:149-59. PMID: 15701580

3. Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation. 6th ed. Baltimore: Williams & Wilkins, 2002.

Chlorpropamide Identification

Substance Name

Chlorpropamide

CAS Registry Number

94-20-2

Drug Class

Hypoglycemic Agents

Sulfonylurea Compounds

Administrative Information

LactMed Record Number

66

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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