Cefoperazone use while Breastfeeding

Drugs containing Cefoperazone: Cefobid

Cefoperazone Levels and Effects while Breastfeeding

Summary of Use during Lactation

Cefoperazone is acceptable to use during breastfeeding. Limited information indicates that maternal doses of cefoperazone up to 1 gram produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with cephalosporins, but these effects have not been adequately evaluated.

Drug Levels

Maternal Levels. After 1 gram of cefoperazone intravenously in 5 women, it was undetectable in milk in 2 women at any time up to 6 hours after the dose. The average peak milk levels of 0.33 mg/L occurred 2 hours after the dose, but in individuals, peak levels occurred 2, 3 or 4 hours after the dose.[1]

After 1 gram of cefoperazone given intravenously in 2 women, milk cefoperazone was 0.1 mg/L at 2 hours and 0.3 mg/L 3 hours after the dose. It was undetectable in milk 1 and 6 hours after the dose.[2][3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

References

1. Takase Z, Shirafuji H, Uchida M. Fundamental and clinical studies of cefoperazone (T-1551) in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1980;28 (Suppl 6):825-36.

2. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. PMID: 6743732

3. Matsuda S, Kashiwagura T, Hirayama H. Passage into the human milk and clinical evaluation of sulbactam/cefoperazone. Jpn J Antibiot. 1985;38:223-9. PMID: 2989572

Cefoperazone Identification

Substance Name

Cefoperazone

CAS Registry Number

62893-19-0

Drug Class

Administrative Information

LactMed Record Number

48

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

Hide
(web4)