Carbinoxamine use while Breastfeeding
Drugs containing Carbinoxamine: Palgic, Carboxine, Andehist, Cydec, Arbinoxa, Pediatex, Aridex, DMax, Palgic DS, Karbinal ER, Show all 95 »Pediox, Tri-Vent HC, Biodec DM, Mintex PSE, Carbiset, Palgic-DC, Carboxine 12D, Coldec, Coldec D, Aridex-D Pediatric, Pannaz, Nacon, Pseudox M, Pannaz S, Andec, Norel LA, Aridex-D, HistamaxD, XiraHist, X-Hist, Palgic-D, Cordron-12 D, Cordron-D NR, Pediatex-D, Cordron-D, Pseudo Carb, Carboxine-D, Carbodec, Pediatex 12D, PSE Allergy, Carboxine-PSE, Hydro-Tussin CBX, Mintex HC, Maldec, Cardec-S, Rondamine, Andec-TR, Carbic-D, Coldec-TR, Ex-Dec-TR, Dura-Ron, Mooredec, Excof-SF, Carbodex DM Drops, Andehist DM NR, DMax Syrup, DMax Pediatric Drops, Cordron-DM, Dynatuss, Tussafed, Pediatex 12 DM, Cordron-12 DM, X-Hist DM, XiraHistDM, Histex IE, Histex CT, Pediatex 12, Cordron NR, Histex PD, DMax Pediatric, Dacex-A, TriTuss-A Drops, Trituss-A, Rondamine DM, Maldec-DM, Carboxine 12 DM, Carboxine DM, PSE Carb DM Drops, PSE Carbinoxamine DM, Carb PSE 12 DM, PSE Allergy DM, Donatussin MAX, Excof, Max HC, Mintex DM, Pseudo Carb DM, Cydec-DM Drops, Dura-Ron DM, Cydec-DM Syrup, Carbaxef-DM, Carbofed DM Drops, Cordron-DM NR, Pediatex-DM, Decahist-DM, Histex HC
Carbinoxamine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small occasional doses of carbinoxamine are probably acceptable during breastfeeding. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
There are no reports of infants breastfed during maternal therapy with carbinoxamine. In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.
Possible Effects on Lactation
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of carbinoxamine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
CAS Registry Number
LactMed Record Number
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
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