Skip to main content

Carbinoxamine use while Breastfeeding

Medically reviewed by Drugs.com. Last updated on Oct 12, 2023.

Drugs containing Carbinoxamine: Histex PD, Aridex, Pannaz, Ryvent, Karbinal ER, Arbinoxa, PSE Allergy DM, Nacon, Biohist LA, Carbodec, Show all 97 »Andec, Mooredec, Maldec, Palgic, Cordron NR, Pediatex, Pediox, Carboxine, Pediatex 12, Histex CT, Histex IE, DMax, TriTuss-A Drops, Dacex-A, XiraHistDM, X-Hist DM, DMax Pediatric Drops, DMax Syrup, DMax Pediatric, Trituss-A, Andehist DM NR, Carbodex DM Drops, Cordron-DM, Dynatuss, Tussafed, Biodec DM, Rondamine DM, Maldec-DM, Cydec-DM Syrup, Dura-Ron DM, Cydec-DM Drops, Carbaxef-DM, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Cordron-DM NR, Pseudo Carb DM, Mintex DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Carboxine DM, Carboxine 12 DM, Carb PSE 12 DM, Cordron-12 DM, Pediatex 12 DM, Excof, Donatussin MAX, Excof-SF, Max HC, Tri-Vent HC, Histex HC, Mintex HC, Pannaz S, Pseudox M, Aridex-D Pediatric, Norel LA, XiraHist, HistamaxD, Aridex-D, X-Hist, Coldec D, Coldec, Pediatex 12D, Carboxine 12D, Carbiset, Cydec, Palgic-DC, Rondamine, Cardec-S, Palgic-D, Andec-TR, Carbic-D, Dura-Ron, Ex-Dec-TR, Coldec-TR, Andehist, Hydro-Tussin CBX, Carboxine-PSE, Cordron-D, Pediatex-D, Cordron-D NR, Cordron-12 D, Pseudo Carb, Carboxine-D, PSE Allergy, Mintex PSE, Palgic DS

Carbinoxamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small occasional doses of carbinoxamine are probably acceptable during breastfeeding. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The manufacturer recommends avoiding breastfeeding during carbinoxamine use because severe toxicity has occurred in children under 2 years. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

There are no reports of infants breastfed during maternal therapy with carbinoxamine. In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.[1]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2,3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of carbinoxamine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1.
Ito S, Blajchman A, Stephenson M, et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393–9. [PubMed: 8498418]
2.
Messinis IE, Souvatzoglou A, Fais N, et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143–6. [PubMed: 3928731]
3.
Pontiroli AE, De Castro e Silva E, Mazzoleni F, et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: Sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924–8. [PubMed: 7228996]

Substance Identification

Substance Name

Carbinoxamine

CAS Registry Number

486-16-8

Drug Class

Breast Feeding

Lactation

Antihistamines

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.