Carbenicillin Indanyl Disodium use while Breastfeeding

Carbenicillin Indanyl Disodium Levels and Effects while Breastfeeding

Summary of Use during Lactation

Carbenicilin is acceptable to use during breastfeeding. Limited information indicates that maternal doses of carbenicillin produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with penicillins, but these effects have not been adequately evaluated.

Drug Levels

Maternal Levels. Milk levels have not been reported after oral doses of carbenicillin. After a single 1 gram intramuscular dose of carbenicillin in 3 women, milk levels averaged between 0.1 and 0.24 mg/L over the first 6 hours after the dose. Peak milk levels occurred 4 hours after the intramuscular dose.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

References

1. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. PMID: 6743732

Carbenicillin Indanyl Disodium Identification

Substance Name

Carbenicillin Indanyl Disodium

CAS Registry Number

4697-36-3

Drug Class

• Antiinfective Agents
• Antibacterial Agents
• Penicillins

Administrative Information

LactMed Record Number

39

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2012-03-01

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