Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Resperal-DM, Bromfed, Dimetapp Elixir, Dimetapp Children's Cold & Cough, Alahist DM, J-Tan, Rynex DM, Lodrane D, Dimetapp Children's Cold & Allergy, Show all 270 »Lodrane 24, DM Cold and Cough, ENT, Bidhist-D, Mar-cof BP, M-End WC, Lohist-DM, Brometane DX, Bromadine-DM, TL-Hist DM, Pulmari, Brotapp, Brotapp-DM, BroveX-D, Dimetane DX, Brovex, M-END, Lodrane 12 Hour, J-Tan PD, Bromaphen, Bromaline, Allent, Lodrane 12D, Dimetane Extentab, VaZol, Sildec, LoHist-12D, J-Cof DHC, LoHist-12, Lodrane, Lodrane 24D, Ala-Hist, Bromdex D, Bromax, Robitussin Allergy & Cough, Histinex DM, Bromplex HD, Bromfenex PE, Vazotan, Bromaphedrine D, Brom Tann PE, BroveX ADT, Phenyl 15/12mg, Seradex-LA, Dimetane Decongestant, J-Tan D SR, Phenyl 7.5/6mg, Bromfed-PD Capsules, Drocon-CS, SymTan A, Brovex HC, Anaplex HD, Bromph HD, Bromcomp HC, Visvex, VazoTuss HC, FluTuss HC, Tusnel-HC, Ala-Hist D, Canges-HC, VasoTuss HC, Canges-HC NR, BPM PE HC, J-Tan D HC, Endacof HC, Alenaze-D NR, B-Vex D, BPM PE, VaZol-D, Dimaphen Elixir, Alacol, VazoBid, Rhinabid PD, Vazotab, Decon-A, Alenaze-D, J-Tan D, Rhinabid, Bromfenex PE Pediatric, Zotex-PE, BroveX PEB, Myphetapp, Bromhist Pediatric Drops, Q-Tapp, AccuHist Pediatric, Unit-Tex 10/120 ER, Di-Bromm, Unit-Hist Drops, Bromaxefed RF Syrup, Andehist NR Syrup, Pseubrom, Iofed, Lodrane Liquid, Nalfed, Touro Allergy, Bromhist-NR, Brovex SR, Brofed, Rynex PSE, Bromfed PD, Bromfed SR, Dimaphen, LoHist PSB, BroveX PSE, J-TanD PD, LoHist-PD, BroveX PD, BroveX PSB, B-Vex PD, Ultrabrom, M-Hist TD, LoHist PEB, Brotapp PE, Dime Time Extended Release, Dibrom, Centussin DHC, Altatapp, Brohist D, Rynex PE, Tanabid SR, RespaHist II, Entre-B, V-HIST, Vazobid-PD, Bromfenex, Histex SR, Iofed PD, Respahist, Ultrabrom PD, Pseubrom-PD, Bromfenex PD, Nalfed PD, Lodrane LD, Endafed, Bromhist Pediatric, Touro A&H, Shellcap, Shellcap PD, BroveX PB, P-Hist DM Drops, Allanhist PDX Syrup, Uni-Hist PDX Syrup, EndaCof-PD, Acutuss DM Pediatric, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, AccuHist PDX Syrup, Bromhist-PDX, Poly-Histine CS, Myphetane DC, Trihist-CS, Liquihistine CS, Polytine CS, Poly CS, Bromhist-DM, Pediahist DM Syrup, Dimaphen DM, Dur-Tann DM, Cold & Cough Childrens, BroveX PEB DM, BPM PE DM, Duravent DPB, Bromtuss DM, Tusdec-DM, BP Allergy DM, Histacol DM Pediatric Syrup, Alacol DM, Bromatan-DM, DuraTan DM, Dimetane DC, TL-Hist CD, Respa BR, P-Tex, Tanacof-XR, B-Vex, Cophene B, Codimal A, Lodrane XR, Bidhist, Brovex CT, Dristan Cold Maximum Strength, Veltane, Dimetapp Allergy, Siltane, BetaTan, Seradex, BroveX CBX, BroveX CB, Poly-Tussin AC, M-End PE, BroveX PB CX, BroveX PB C, EndaCof-AC, Nalex AC, V-COF, Trexbrom (old formulation), Trexbrom, Dicel CD, SymPak II, BroveX PB DM, Balacall DM, Uni-Hist PDX Drops, Bromph DM, Allanhist PDX Drops, Histacol BD Drops, ProHist DM, Brom Tann, Q-Tapp DM, Pediahist DM Drops, Carbofed DM Syrup, Bromaline DM, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, Comtrex Acute Head Cold, Sildec DM, Bromphenex DM, EndaCof PD Drops, Bromtapp-DM, PSE Brom DM, Poly-Tussin DHC, Dimetapp DM, Carbodex DM Syrup, PBM Allergy, EndaCof-DM, Dallergy DM, Neo DM Syrup, BroveX PSE DM Tablets, BroveX PSE DM, Bromaxefed DM RF Syrup, Andehist DM NR Syrup, Polytine DM, Delhistine DM, Iohist DM, KG Hist DM, Liquihistine DM, Uni Multihist DM, Highland DM, Poly DM, Brotapp PE-DM, Tussi-Pres B, AP-Hist DM, BPM DM PHEN, Prohistine DM, Trihist DM, Poly Histine DM, Bromatane DX, Bromanate DX Cough, Myphetane DX Cough, Bromophed-DX, Anaplex DM, Liquiphed DM, Myphetane DX, BromTann/DM Tann/PSE Tann, BroveX PSB DM, Durahistine DM, AccuHist DM Pediatric Drops, PediaHist DM, Anaplex DMX, EndaCof-DH

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Possible Effects on Lactation

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

Substance Name

Brompheniramine

CAS Registry Number

86-22-6

Drug Class

Administrative Information

LactMed Record Number

34

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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