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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Rynex DM, Dimetapp Elixir, Dimetapp Children's Cold & Cough, Alahist DM, Dimetane Extentab, Rynex PE, Dimetane DX, Show all 279 »Brotapp-DM, Dime Time Extended Release, Dimetapp Children's Cold & Allergy, M-End PE, Lodrane, Tussi-Pres B, Lodrane 24D, Mar-cof BP, Lodrane D, Poly-Tussin AC, Ru-Hist D, Veltane, Dimetapp Allergy, Tusnel-HC, ENT, Presgen B, Bromfed-PD Capsules, M-End WC, LoHist-12D, LoHist-12, Ala-Hist, Q-Tapp DM, Bromaline, Bromadine-DM, P-Hist DM Drops, Robitussin Allergy & Cough, Bromaphen, Dimaphen DM, Brometane DX, Lodrane Liquid, Bromfed PD, Brofed, P-Tex, Ultrabrom PD, Bromfenex, J-TanD PD, Brotapp, Histaject, Bromhist-PDX, Bromophed-DX, Poly Histine DM, DM Cold and Cough, Brovex, Bromdex D, BroveX PSE DM, Dimetapp DM, Vazotan, Seradex, BPM PE, Dimetane Decongestant, J-Cof DHC, Dallergy DM, Histinex DM, J-Tan, Decon-A, BroveX PB, Alacol, Entre-B, LoHist PEB, VazoBid, J-Tan D, BroveX-D, VaZol-D, Drocon-CS, M-END, Anaplex HD, Bromplex HD, Bromph HD, Canges-HC, VazoTuss HC, VasoTuss HC, Ala-Hist D, BPM PE HC, Canges-HC NR, FluTuss HC, Visvex, Bromcomp HC, B-Vex D, Rhinabid PD, Bromaphedrine D, Alenaze-D NR, Vazotab, Bromfenex PE Pediatric, Bromfenex PE, Brovex HC, Endacof HC, SymTan A, J-Tan D HC, Rhinabid, Dimaphen Elixir, Dibrom, Histex SR, Bromfenex PD, M-Hist TD, Ultrabrom, Pseubrom, Iofed, Pseubrom-PD, Iofed PD, Shellcap PD, Allent, Lodrane LD, Nalfed PD, Respahist, Nalfed, Touro Allergy, Di-Bromm, Unit-Hist Drops, Bromhist-NR, Brovex SR, LoHist-PD, Dimaphen, Unit-Tex 10/120 ER, AccuHist Pediatric, Bromaxefed RF Syrup, Andehist NR Syrup, Sildec, Q-Tapp, Bromhist Pediatric Drops, Shellcap, Touro A&H, Alenaze-D, Brohist D, RespaHist II, Brotapp PE, Seradex-LA, Tanabid SR, Brom Tann PE, J-Tan D SR, Zotex-PE, BroveX PEB, V-HIST, Phenyl 7.5/6mg, Phenyl 15/12mg, Vazobid-PD, Altatapp, BroveX PSB, BroveX PD, B-Vex PD, Bromhist Pediatric, Endafed, BroveX PSE, Rynex PSE, LoHist PSB, Myphetapp, Bromfed SR, Bidhist-D, Lodrane 12D, BroveX ADT, Bromtapp-DM, Polytine CS, Poly CS, Rydex, Mesehist WC, Uni-Hist PDX Syrup, AccuHist PDX Syrup, Liquihistine CS, Trihist-CS, TL-Hist CD, BroveX PB CX, Dimetane DC, Myphetane DC, Poly-Histine CS, Allanhist PDX Syrup, EndaCof-PD, Duravent DPB, BPM DM PHEN, Alacol DM, BP Allergy DM, Tusdec-DM, TL-Hist DM, BroveX PB DM, Histacol DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Acutuss DM Pediatric, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, BroveX PB C, EndaCof-AC, VaZol, B-Vex, Lodrane 12 Hour, Lodrane 24, Nasahist B, Brovex CT, Cophene B, Codimal A, J-Tan PD, Dristan Cold Maximum Strength, Bromax, Tanacof-XR, Prop-A-Tane, ND-Stat, Siltane, Dicel CD, Trexbrom, SymPak II, Nalex AC, BroveX CBX, BroveX CB, Pulmari, BetaTan, Bidhist, Respa BR, Lodrane XR, Trexbrom (old formulation), V-COF, Bromtuss DM, Dur-Tann DM, Andehist DM NR Syrup, Bromphenex DM, Comtrex Acute Head Cold, Bromaxefed DM RF Syrup, Bromaline DM, PSE Brom DM, Anaplex DM, Liquiphed DM, Myphetane DX, Neo DM Syrup, Bromanate DX Cough, Bromatane DX, Myphetane DX Cough, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, ProHist DM, Brom Tann, Carbodex DM Syrup, Sildec DM, Poly-Tussin DHC, Centussin DHC, Histacol BD Drops, Allanhist PDX Drops, Bromhist-DM Drops, Bromplex DM, Pediahist DM Drops, Bromph DM, Uni-Hist PDX Drops, BromTann/DM Tann/PSE Tann, Anaplex DMX, DuraTan DM, Bromatan-DM, EndaCof-DM, AP-Hist DM, Poly DM, Prohistine DM, Lohist-DM, Brotapp PE-DM, BroveX PEB DM, Cold & Cough Childrens, BPM PE DM, LoHist PEB DM, Balacall DM, Highland DM, Delhistine DM, AccuHist DM Pediatric Drops, EndaCof PD Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSB DM, PBM Allergy, Durahistine DM, Trihist DM, Iohist DM, Polytine DM, KG Hist DM, Uni Multihist DM, Liquihistine DM, EndaCof-DH

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

Substance Name

Brompheniramine

CAS Registry Number

86-22-6

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

34

Last Revision Date

20150310

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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