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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Rynex DM, Dimetapp Elixir, Dimetapp Children's Cold & Cough, Alahist DM, Rynex PE, Brotapp-DM, Bromatane DX, Show all 280 »Dimetane Extentab, Dimetane DX, Dimetapp Children's Cold & Allergy, Lodrane D, Bromfed-PD Capsules, Tussi-Pres B, Poly-Tussin AC, Cophene B, Ala-Hist, Dimetapp Allergy, Lodrane 24D, Bromfenex, LoHist-12D, Q-Tapp DM, Ru-Hist D, Lodrane, Presgen B, Bromax, Poly-Tussin DHC, Brotapp, M-End WC, Bromaline, Histaject, BroveX PSE DM, Dallergy DM, Bromdex D, Lodrane Liquid, Dimetapp DM, Ultrabrom PD, Bromaphen, P-Tex, Histinex DM, Veltane, Brofed, Brometane DX, Bromfed PD, Bromhist-PDX, Robitussin Allergy & Cough, Decon-A, Dimetane Decongestant, M-END, VasoTuss HC, ENT, Poly Histine DM, Seradex, M-End PE, Alenaze-D NR, B-Vex D, VaZol-D, Bromaphedrine D, Alacol, LoHist PEB, BroveX-D, Entre-B, BPM PE, VazoBid, BroveX PB, Dimaphen Elixir, Rhinabid PD, FluTuss HC, Canges-HC NR, VazoTuss HC, Canges-HC, Drocon-CS, BPM PE HC, Tusnel-HC, Centussin DHC, EndaCof-DH, J-Cof DHC, Ala-Hist D, Anaplex HD, Bromplex HD, J-Tan D HC, Rhinabid, Bromfenex PE, Bromfenex PE Pediatric, SymTan A, Brovex HC, Bromph HD, Visvex, Bromcomp HC, Endacof HC, J-Tan D, Dime Time Extended Release, Histex SR, Bromfenex PD, M-Hist TD, Ultrabrom, Pseubrom, Iofed, Pseubrom-PD, Iofed PD, Allent, Shellcap, Shellcap PD, Lodrane LD, Respahist, Nalfed PD, Nalfed, Touro Allergy, Bromhist-NR, Di-Bromm, Brovex SR, Dimaphen, J-TanD PD, LoHist-PD, Unit-Hist Drops, Unit-Tex 10/120 ER, Bromaxefed RF Syrup, Andehist NR Syrup, Sildec, Q-Tapp, AccuHist Pediatric, Bromhist Pediatric Drops, Touro A&H, Endafed, Alenaze-D, Brohist D, RespaHist II, Brotapp PE, Seradex-LA, Tanabid SR, Brom Tann PE, J-Tan D SR, BroveX PEB, BroveX ADT, Zotex-PE, V-HIST, Phenyl 15/12mg, Phenyl 7.5/6mg, Vazobid-PD, Sildec DM, BroveX PSE, Rynex PSE, BroveX PD, BroveX PSB, Bromhist Pediatric, B-Vex PD, Lodrane 12D, Bidhist-D, Altatapp, Dibrom, Myphetapp, LoHist PSB, Bromfed SR, Vazotab, Bromtapp-DM, Poly CS, Liquihistine CS, Polytine CS, Mar-cof BP, Mesehist WC, Rydex, Trihist-CS, Poly-Histine CS, BroveX PB C, EndaCof-AC, BroveX PB CX, TL-Hist CD, Myphetane DC, Dimetane DC, AccuHist PDX Syrup, Uni-Hist PDX Syrup, BroveX PB DM, Histacol DM Pediatric Syrup, BPM DM PHEN, Duravent DPB, BP Allergy DM, Alacol DM, Pediahist DM Syrup, Bromhist-DM, EndaCof-PD, Allanhist PDX Syrup, Acutuss DM Pediatric, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, BroveX CBX, BroveX CB, Lodrane 12 Hour, VaZol, Lodrane 24, Brovex, Brovex CT, J-Tan, LoHist-12, B-Vex, Dristan Cold Maximum Strength, Comtrex Acute Head Cold, J-Tan PD, Tanacof-XR, Codimal A, Prop-A-Tane, Nasahist B, ND-Stat, Pulmari, Vazotan, Trexbrom, Dicel CD, Nalex AC, SymPak II, BetaTan, V-COF, Respa BR, Siltane, Bidhist, Lodrane XR, Trexbrom (old formulation), TL-Hist DM, Tusdec-DM, Bromadine-DM, Liquiphed DM, Anaplex DM, Bromphenex DM, Staflex, Andehist DM NR Syrup, Bromophed-DX, Myphetane DX Cough, Anaplex DMX, BroveX PSB DM, BromTann/DM Tann/PSE Tann, Neo DM Syrup, Bromanate DX Cough, Myphetane DX, Bromaxefed DM RF Syrup, PSE Brom DM, Allanhist PDX Drops, Uni-Hist PDX Drops, Histacol BD Drops, Brom Tann, P-Hist DM Drops, ProHist DM, Bromph DM, Pediahist DM Drops, Carbofed DM Syrup, Bromaline DM, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, PBM Allergy, BroveX PSE DM Tablets, Lohist-DM, Brotapp PE-DM, Bromatan-DM, DuraTan DM, AP-Hist DM, EndaCof-DM, Balacall DM, LoHist PEB DM, Dur-Tann DM, Bromtuss DM, Dimaphen DM, Cold & Cough Childrens, BPM PE DM, BroveX PEB DM, Prohistine DM, Poly DM, DM Cold and Cough, Trihist DM, Durahistine DM, EndaCof PD Drops, PediaHist DM, AccuHist DM Pediatric Drops, Liquihistine DM, Uni Multihist DM, Delhistine DM, Highland DM, Polytine DM, Iohist DM, KG Hist DM, Carbodex DM Syrup

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

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Administrative Information

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