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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Dimetapp Elixir, Dimetapp Children's Cold & Cough, Rynex DM, Dimetapp DM, Dimetapp Children's Cold & Allergy, Dimetane DX, Resperal-DM, Bromaline, Show all 282 »M-END, Brotapp-DM, Alahist DM, ENT, AccuHist DM Pediatric Drops, Brovex, Dimetapp Allergy, BromTann/DM Tann/PSE Tann, Poly Histine DM, BroveX PSB DM, Pseubrom, Bromadine-DM, Rynex PE, Dimaphen Elixir, M-End PE, Pseubrom-PD, Shellcap, Bromax, TL-Hist DM, Lohist-DM, DM Cold and Cough, Lodrane, Tussi-Pres B, Robitussin Allergy & Cough, Visvex, Dristan Cold Maximum Strength, Lodrane D, Bromhist Pediatric, Lodrane 24D, LoHist-12, M-End WC, Bromhist-DM, Dimetane Extentab, ND-Stat, Histaject, Presgen B, Cophene B, Dimaphen DM, Bromophed-DX, Neo DM Syrup, VazoBid, Bromaphedrine D, Brovex HC, Decon-A, BroveX PEB, J-Tan D, BroveX-D, LoHist PEB, Dimetane Decongestant, Centussin DHC, Entre-B, Poly-Tussin DHC, EndaCof-DH, BPM PE, B-Vex D, J-Cof DHC, VaZol-D, BroveX PB, Alenaze-D NR, Bromfed-PD Capsules, Rhinabid PD, Alacol, Canges-HC NR, Bromplex HD, Anaplex HD, Drocon-CS, Rhinabid, J-TanD PD, J-Tan D HC, Bromcomp HC, Endacof HC, SymTan A, Bromfenex PE, Bromfenex PE Pediatric, BPM PE HC, VasoTuss HC, Tusnel-HC, Ala-Hist D, Bromph HD, FluTuss HC, Vazotab, Canges-HC, VazoTuss HC, Ala-Hist, Alenaze-D, Ultrabrom PD, Iofed PD, Bromfenex, Bromfenex PD, M-Hist TD, Histex SR, Respahist, Nalfed PD, Endafed, B-Vex PD, Touro A&H, Allent, Lodrane LD, Shellcap PD, Ultrabrom, Iofed, Unit-Tex 10/120 ER, AccuHist Pediatric, Unit-Hist Drops, Di-Bromm, Brotapp, Bromhist-NR, Bromhist Pediatric Drops, Q-Tapp, Nalfed, Lodrane Liquid, Touro Allergy, Andehist NR Syrup, Sildec, Bromaxefed RF Syrup, BroveX PSB, BroveX PD, RespaHist II, Brovex SR, Brotapp PE, Tanabid SR, Vazobid-PD, Seradex-LA, Brohist D, Brom Tann PE, Zotex-PE, Ru-Hist D, V-HIST, Phenyl 7.5/6mg, J-Tan D SR, Phenyl 15/12mg, Dime Time Extended Release, Sildec DM, Bromfed SR, Bromfed PD, Bidhist-D, Lodrane 12D, BroveX PSE, Rynex PSE, Brofed, LoHist PSB, LoHist-12D, Dibrom, Altatapp, Myphetapp, Dimaphen, LoHist-PD, BroveX ADT, Bromtapp-DM, Liquihistine CS, Trihist-CS, Poly CS, Polytine CS, Rydex, Mar-cof BP, Poly-Histine CS, Myphetane DC, BroveX PB C, EndaCof-AC, BroveX PB CX, TL-Hist CD, Dimetane DC, Poly-Tussin AC, Mesehist WC, AccuHist PDX Syrup, Histacol DM Pediatric Syrup, Pediahist DM Syrup, Niva-Hist DM, BroveX PB DM, Duravent DPB, BPM DM PHEN, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Allanhist PDX Syrup, Uni-Hist PDX Syrup, EndaCof-PD, Bromhist-PDX, Acutuss DM Pediatric, BroveX CBX, BroveX CB, VaZol, B-Vex, Lodrane 12 Hour, Lodrane 24, Brovex CT, J-Tan, Codimal A, Veltane, P-Tex, Comtrex Acute Head Cold, Bromaphen, J-Tan PD, Prop-A-Tane, Tanacof-XR, Nasahist B, Siltane, Seradex, Pulmari, Trexbrom, Dicel CD, Nalex AC, SymPak II, Vazotan, BetaTan, Bidhist, Respa BR, Lodrane XR, Trexbrom (old formulation), V-COF, Alacol DM, BP Allergy DM, Anaplex DM, Brometane DX, Bromphenex DM, Andehist DM NR Syrup, Bromaxefed DM RF Syrup, Staflex, Liquiphed DM, Myphetane DX Cough, Bromdex D, Anaplex DMX, Dallergy DM, Myphetane DX, Bromatane DX, Bromanate DX Cough, PSE Brom DM, Bromaline DM, Allanhist PDX Drops, Uni-Hist PDX Drops, Histacol BD Drops, Brom Tann, P-Hist DM Drops, ProHist DM, Bromph DM, Q-Tapp DM, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, PBM Allergy, BroveX PSE DM, Brotapp PE-DM, Balacall DM, Bromatan-DM, DuraTan DM, AP-Hist DM, EndaCof-DM, LoHist PEB DM, BPM PE DM, Tusdec-DM, Y-COF DMX, Bromtuss DM, Dur-Tann DM, BroveX PEB DM, Cold & Cough Childrens, Histinex DM, Prohistine DM, Trihist DM, Liquihistine DM, Durahistine DM, EndaCof PD Drops, BroveX PSE DM Tablets, PediaHist DM, Uni Multihist DM, KG Hist DM, Highland DM, Poly DM, Delhistine DM, Polytine DM, Iohist DM, Carbodex DM Syrup

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

Substance Name

Brompheniramine

CAS Registry Number

86-22-6

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

34

Last Revision Date

20150310

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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