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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Rynex DM, Dimetapp Elixir, Alahist DM, Dimetapp Children's Cold & Cough, Dimetane DX, Brotapp-DM, Rynex PE, Show all 275 »Dimetane Extentab, M-End PE, Dime Time Extended Release, Cold & Cough Childrens, Mar-cof BP, Bromfenex, Dimetapp Allergy, Tusnel-HC, Veltane, Q-Tapp DM, Dimaphen DM, Bromfed-PD Capsules, Lodrane, Bromaline, Brovex, Tussi-Pres B, Lodrane 24D, Q-Tapp, Brometane DX, LoHist-12, Ala-Hist, DM Cold and Cough, ENT, Poly-Tussin AC, Seradex, Lohist-DM, Ultrabrom PD, Shellcap, J-TanD PD, Lodrane D, Brotapp, Robitussin Allergy & Cough, BroveX PSE DM, BroveX PSB DM, Histinex DM, Poly Histine DM, Dimetapp DM, Bromdex D, Dallergy DM, ProHist DM, Bromfed PD, P-Hist DM Drops, Bromadine-DM, Bromophed-DX, AP-Hist DM, M-End WC, Vazotan, J-Cof DHC, M-END, BPM PE, Dimetane Decongestant, LoHist PEB, Dimetapp Children's Cold & Allergy, J-Tan, Bromhist-PDX, Bromaphen, P-Tex, Lodrane 24, Bromax, Histaject, Endacof HC, Visvex, Bromcomp HC, Canges-HC, FluTuss HC, BroveX ADT, VazoTuss HC, Drocon-CS, Bromplex HD, Anaplex HD, Bromph HD, LoHist-12D, BroveX PB, VazoBid, Dimaphen Elixir, VaZol-D, BroveX PEB, Alacol, BroveX-D, J-Tan D, Vazotab, Alenaze-D NR, Bromaphedrine D, Entre-B, J-Tan D HC, SymTan A, Rhinabid, Bromfenex PE, B-Vex D, Rhinabid PD, Bromfenex PE Pediatric, Brovex HC, Altatapp, Histex SR, Bromfenex PD, M-Hist TD, Ultrabrom, Pseubrom, Iofed, Pseubrom-PD, Iofed PD, Shellcap PD, Allent, Lodrane LD, Nalfed PD, Respahist, Lodrane Liquid, Nalfed, Di-Bromm, Unit-Hist Drops, Bromhist-NR, Brovex SR, LoHist-PD, Dimaphen, Unit-Tex 10/120 ER, AccuHist Pediatric, Andehist NR Syrup, Touro Allergy, Bromaxefed RF Syrup, Sildec, Bromhist Pediatric Drops, Touro A&H, Endafed, RespaHist II, Decon-A, Brotapp PE, Tanabid SR, Vazobid-PD, Seradex-LA, Alenaze-D, Brohist D, Phenyl 7.5/6mg, V-HIST, Phenyl 15/12mg, J-Tan D SR, Brom Tann PE, Dibrom, Myphetapp, BroveX PD, BroveX PSE, BroveX PSB, B-Vex PD, Bromhist Pediatric, Rynex PSE, Lodrane 12D, LoHist PSB, Canges-HC NR, Brofed, Bromfed SR, Bidhist-D, Zotex-PE, Bromtapp-DM, Mesehist WC, Polytine CS, AccuHist PDX Syrup, Uni-Hist PDX Syrup, EndaCof-PD, Allanhist PDX Syrup, Poly CS, Liquihistine CS, Dimetane DC, TL-Hist CD, Myphetane DC, Poly-Histine CS, Trihist-CS, Acutuss DM Pediatric, Uni-Hist DM Pediatric Syrup, BP Allergy DM, Alacol DM, TL-Hist DM, Tusdec-DM, Bromtuss DM, Duravent DPB, BPM DM PHEN, Bromhist-DM, AccuHist DM Pediatric Syrup, Pediahist DM Syrup, Histacol DM Pediatric Syrup, BroveX PB DM, BroveX PB CX, BroveX PB C, Brovex CT, Lodrane 12 Hour, Nasahist B, ND-Stat, Siltane, VaZol, B-Vex, J-Tan PD, Dristan Cold Maximum Strength, Tanacof-XR, Codimal A, Cophene B, Respa BR, Bidhist, Nalex AC, SymPak II, BroveX CB, BroveX CBX, EndaCof-AC, Dicel CD, Trexbrom, Trexbrom (old formulation), Lodrane XR, V-COF, BetaTan, Pulmari, Dur-Tann DM, BroveX PEB DM, PSE Brom DM, Bromaxefed DM RF Syrup, Bromaline DM, Carbofed DM Syrup, Bromplex DM, Uni-Hist DM Pediatric Drops, Comtrex Acute Head Cold, Andehist DM NR Syrup, Myphetane DX Cough, Bromatane DX, Liquiphed DM, Anaplex DM, Bromphenex DM, Bromhist-DM Drops, Pediahist DM Drops, Poly-Tussin DHC, Centussin DHC, EndaCof-DH, Ala-Hist D, VasoTuss HC, Sildec DM, Carbodex DM Syrup, Uni-Hist PDX Drops, Bromph DM, Allanhist PDX Drops, Histacol BD Drops, Brom Tann, Bromanate DX Cough, Myphetane DX, Poly DM, Prohistine DM, Highland DM, Delhistine DM, Polytine DM, EndaCof-DM, DuraTan DM, LoHist PEB DM, BPM PE DM, Balacall DM, Brotapp PE-DM, Bromatan-DM, Iohist DM, KG Hist DM, PBM Allergy, BroveX PSE DM Tablets, Anaplex DMX, BromTann/DM Tann/PSE Tann, Neo DM Syrup, PediaHist DM, AccuHist DM Pediatric Drops, Liquihistine DM, Uni Multihist DM, Trihist DM, Durahistine DM, EndaCof PD Drops, BPM PE HC

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

Substance Name

Brompheniramine

CAS Registry Number

86-22-6

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

34

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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