Brompheniramine use while Breastfeeding
Drugs containing Brompheniramine: Bromfed DM, Resperal-DM, Rynex DM, Bromfed, Dimetapp Elixir, Lodrane 24, Dimetapp DM, Brovex, Dimetapp Children's Cold & Cough, Decon-A, Show all 261 »Dimetane Extentab, Rynex PE, Dimetapp Children's Cold & Allergy, Brometane DX, Dimetapp Allergy, Alahist DM, Lodrane 12 Hour, Dimetane Decongestant, Robitussin Allergy & Cough, BetaTan, M-End WC, Lodrane, Histex SR, PSE Brom DM, TL-Hist DM, Mar-cof BP, Veltane, BroveX PEB DM, Bromaline, Brotapp-DM, Lodrane D, BroveX PSE DM Tablets, Lohist-DM, Dimaphen DM, Tusdec-DM, Endafed, Allent, Brotapp, Rynex PSE, Q-Tapp, Tussi-Pres B, Comtrex Acute Head Cold, Myphetane DX Cough, Dimetane DX, Pulmari, Seradex, Bromophed-DX, M-END, Poly-Tussin DHC, Dristan Cold Maximum Strength, Ala-Hist, J-Cof DHC, Centussin DHC, Bromadine-DM, DM Cold and Cough, Vazotab, Phenyl 7.5/6mg, Seradex-LA, Bromfed-PD Capsules, BroveX PEB, Trexbrom, Cold & Cough Childrens, Anaplex DM, EndaCof-DM, Dimaphen Elixir, Bromaphedrine D, Alenaze-D NR, VaZol-D, Zotex-PE, Anaplex HD, Drocon-CS, Bromplex HD, Bromph HD, Visvex, SymTan A, Brovex HC, BPM PE HC, Canges-HC NR, FluTuss HC, VazoTuss HC, Bromcomp HC, J-Tan D HC, Bromfenex PE, Bromfenex PE Pediatric, Rhinabid PD, BPM PE, VazoBid, Rhinabid, Endacof HC, Alenaze-D, BroveX-D, J-Tan D, B-Vex D, Altatapp, Touro Allergy, Nalfed, Andehist NR Syrup, Bromaxefed RF Syrup, Bromhist Pediatric Drops, Sildec, Lodrane Liquid, Pseubrom, Bromfenex PD, Pseubrom-PD, M-Hist TD, Ultrabrom, Iofed, AccuHist Pediatric, Unit-Tex 10/120 ER, BroveX PD, J-TanD PD, BroveX PSB, B-Vex PD, LoHist PSB, BroveX PSE, LoHist-12D, LoHist-PD, Di-Bromm, Unit-Hist Drops, Bromhist-NR, Brovex SR, Lodrane 24D, Ultrabrom PD, Iofed PD, V-HIST, Entre-B, Vazobid-PD, Brohist D, Dime Time Extended Release, Brotapp PE, Tanabid SR, RespaHist II, Brom Tann PE, BroveX ADT, Phenyl 15/12mg, J-Tan D SR, BroveX PB, Dibrom, ENT, Shellcap PD, Shellcap, Lodrane LD, Nalfed PD, Respahist, Touro A&H, Bromhist Pediatric, Myphetapp, VasoTuss HC, Bromfenex, Bidhist-D, Lodrane 12D, Alacol, Histacol BD Drops, Bromhist-PDX, Polytine CS, AccuHist PDX Syrup, Uni-Hist PDX Syrup, Allanhist PDX Syrup, Poly CS, Liquihistine CS, Dimetane DC, TL-Hist CD, Myphetane DC, Poly-Histine CS, Trihist-CS, EndaCof-PD, Acutuss DM Pediatric, DuraTan DM, Bromatan-DM, Bromtuss DM, Dur-Tann DM, Duravent DPB, Alacol DM, BP Allergy DM, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, BroveX PB CX, BroveX PB C, J-Tan PD, Bromaphen, Respa BR, Tanacof-XR, B-Vex, P-Tex, Lodrane XR, J-Tan, VaZol, Brovex CT, Siltane, Bidhist, LoHist-12, Bromax, BroveX CB, EndaCof-AC, BroveX CBX, Poly-Tussin AC, M-End PE, Nalex AC, SymPak II, Vazotan, Trexbrom (old formulation), V-COF, Dicel CD, BPM PE DM, BroveX PB DM, Allanhist PDX Drops, Uni-Hist PDX Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Bromph DM, Q-Tapp DM, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Sildec DM, Dallergy DM, Bromtapp-DM, Bromphenex DM, EndaCof-DH, Ala-Hist D, Tusnel-HC, EndaCof PD Drops, Carbodex DM Syrup, Neo DM Syrup, BroveX PSE DM, PBM Allergy, Bromdex D, Bromaline DM, Bromaxefed DM RF Syrup, Iohist DM, Polytine DM, KG Hist DM, Uni Multihist DM, Liquihistine DM, Delhistine DM, Highland DM, Brotapp PE-DM, Balacall DM, Histinex DM, Prohistine DM, Poly DM, Trihist DM, Poly Histine DM, Bromanate DX Cough, Myphetane DX, Bromatane DX, Liquiphed DM, Andehist DM NR Syrup, BromTann/DM Tann/PSE Tann, Anaplex DMX, Durahistine DM, BroveX PSB DM, AccuHist DM Pediatric Drops, PediaHist DM, Canges-HC
Brompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Possible Effects on Lactation
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
CAS Registry Number
LactMed Record Number
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- Brompheniramine use during Pregnancy
- Brompheniramine 12-hour sustained-release tablets Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy