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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Dimetapp Elixir, Rynex DM, Robitussin Allergy & Cough, Dimetapp Children's Cold & Allergy, Dimetane Decongestant, Dimetapp Children's Cold & Cough, Shellcap, Show all 281 »ENT, Seradex, Mar-cof BP, Lodrane, Lodrane D, Cophene B, Staflex, Duravent DPB, Tussi-Pres B, VazoTuss HC, Decon-A, J-Tan D SR, Dimetapp DM, ProHist DM, Brotapp-DM, BromTann/DM Tann/PSE Tann, Dimaphen Elixir, BroveX PSE, Seradex-LA, BroveX PEB, Alahist DM, Lohist-DM, Liquihistine DM, Bromatan-DM, BroveX ADT, M-End PE, Rydex, J-Tan D, LoHist-PD, Q-Tapp, Sildec, Rynex PE, Carbofed DM Syrup, Centussin DHC, Lodrane 24, Bromax, Ala-Hist, Bromaphedrine D, Trexbrom, BroveX CB, Bromfed-PD Capsules, Bromfenex PE, Bromfenex PE Pediatric, Carbodex DM Syrup, Poly-Tussin DHC, Rhinabid PD, Sildec DM, B-Vex D, BroveX PB, Alacol, Entre-B, LoHist PEB, VazoBid, VaZol-D, EndaCof-DH, Alenaze-D NR, P-Hist DM Drops, BPM PE, Ala-Hist D, Bromcomp HC, Visvex, Bromph HD, Bromplex HD, Endacof HC, Brovex HC, BroveX-D, J-Tan D HC, SymTan A, Anaplex HD, Drocon-CS, VasoTuss HC, Tusnel-HC, J-Cof DHC, BPM PE HC, Canges-HC NR, M-END, Canges-HC, FluTuss HC, Rhinabid, Vazobid-PD, Ultrabrom, M-Hist TD, Iofed, Pseubrom, Nalfed, Lodrane Liquid, Histex SR, Bromfenex PD, Respahist, Nalfed PD, Iofed PD, Ultrabrom PD, Bromfenex, Pseubrom-PD, Touro Allergy, Andehist NR Syrup, Brovex SR, Brotapp, Dimaphen, Lodrane 24D, J-TanD PD, LoHist-12D, Bromhist-NR, Di-Bromm, Bromaxefed RF Syrup, Bromaline, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Hist Drops, Unit-Tex 10/120 ER, Lodrane LD, Shellcap PD, Brotapp PE, RespaHist II, Tanabid SR, Brom Tann, Dibrom, Dime Time Extended Release, Alenaze-D, Brohist D, Zotex-PE, Ru-Hist D, V-HIST, Phenyl 7.5/6mg, Brom Tann PE, Phenyl 15/12mg, Altatapp, Myphetapp, B-Vex PD, BroveX PSB, Bromhist Pediatric, Endafed, Allent, Touro A&H, BroveX PD, Rynex PSE, Brofed, LoHist PSB, Bromfed PD, Bromfed SR, Lodrane 12D, Bidhist-D, Vazotab, Andehist DM NR Syrup, Poly-Histine CS, Myphetane DC, Trihist-CS, Liquihistine CS, Polytine CS, Poly CS, Dimetane DC, Poly-Tussin AC, BroveX CBX, Nalex AC, EndaCof-AC, BroveX PB C, TL-Hist CD, BroveX PB CX, M-End WC, Mesehist WC, Pediahist DM Syrup, Bromhist-DM, Histacol DM Pediatric Syrup, BroveX PB DM, Alacol DM, BPM DM PHEN, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Uni-Hist PDX Syrup, AccuHist PDX Syrup, Allanhist PDX Syrup, EndaCof-PD, Acutuss DM Pediatric, Bromhist-PDX, SymPak II, Dicel CD, Codimal A, Histaject, B-Vex, LoHist-12, Lodrane 12 Hour, VaZol, Veltane, Prop-A-Tane, Dristan Cold Maximum Strength, Comtrex Acute Head Cold, P-Tex, Bromaphen, Tanacof-XR, J-Tan PD, Brovex, J-Tan, Trexbrom (old formulation), Lodrane XR, V-COF, BetaTan, Pulmari, Vazotan, Bidhist, Respa BR, Nasahist B, Brovex CT, ND-Stat, Dimetapp Allergy, Siltane, Dimetane Extentab, BP Allergy DM, Presgen B, Bromanate DX Cough, Myphetane DX, Bromatane DX, Myphetane DX Cough, Liquiphed DM, Bromophed-DX, Dimetane DX, Dallergy DM, PBM Allergy, BroveX PSE DM, BroveX PSB DM, Anaplex DMX, Neo DM Syrup, Bromdex D, Brometane DX, Bromadine-DM, Pediahist DM Drops, Bromhist-DM Drops, Q-Tapp DM, Bromph DM, Allanhist PDX Drops, Uni-Hist PDX Drops, Bromplex DM, Uni-Hist DM Pediatric Drops, Bromphenex DM, Anaplex DM, Bromtapp-DM, Bromaxefed DM RF Syrup, Bromaline DM, PSE Brom DM, BroveX PSE DM Tablets, PediaHist DM, LoHist PEB DM, BPM PE DM, Balacall DM, Brotapp PE-DM, EndaCof-DM, DuraTan DM, BroveX PEB DM, Cold & Cough Childrens, TL-Hist DM, Y-COF DMX, Tusdec-DM, Bromtuss DM, Dimaphen DM, Dur-Tann DM, AP-Hist DM, Histinex DM, Poly Histine DM, Trihist DM, DM Cold and Cough, Durahistine DM, AccuHist DM Pediatric Drops, EndaCof PD Drops, Uni Multihist DM, KG Hist DM, Poly DM, Prohistine DM, Highland DM, Delhistine DM, Iohist DM, Polytine DM, Histacol BD Drops

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

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Administrative Information

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