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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Dimetapp Elixir, Rynex DM, Q-Tapp, Dimetapp Children's Cold & Cough, Dristan Cold Maximum Strength, Robitussin Allergy & Cough, Lodrane, Show all 281 »Rynex PSE, Lodrane D, Dimetapp Children's Cold & Allergy, Lodrane 24, Bromadine-DM, Mar-cof BP, Brotapp, Brotapp-DM, Dimetapp DM, AccuHist PDX Syrup, M-End PE, Dimetane DX, Bromfed PD, Alahist DM, Dimetane Extentab, Staflex, Tussi-Pres B, Bromaline, Lodrane 24D, BromTann/DM Tann/PSE Tann, Myphetane DX, Phenyl 15/12mg, Carbofed DM Syrup, ENT, Lohist-DM, BroveX ADT, BroveX PEB, Phenyl 7.5/6mg, Rydex, ProHist DM, Brometane DX, Codimal A, Bromax, P-Tex, Trexbrom, Alacol, Bromfed-PD Capsules, Bromaphedrine D, Bromfenex PE, J-Cof DHC, Rhinabid, Bromfenex PE Pediatric, Carbodex DM Syrup, Centussin DHC, Rhinabid PD, Sildec DM, Alenaze-D NR, Entre-B, Rynex PE, LoHist PEB, BroveX-D, BroveX PB, VazoBid, B-Vex D, Poly-Tussin DHC, VaZol-D, Dimaphen Elixir, BPM PE, Ala-Hist D, Bromcomp HC, Visvex, Bromph HD, Bromplex HD, Endacof HC, Brovex HC, J-Tan D, J-Tan D HC, SymTan A, Anaplex HD, Drocon-CS, BPM PE HC, VasoTuss HC, Tusnel-HC, Ala-Hist, Canges-HC NR, FluTuss HC, M-END, Canges-HC, VazoTuss HC, EndaCof-DH, Seradex-LA, M-Hist TD, Histex SR, Bromfenex PD, Ultrabrom, Iofed, Lodrane Liquid, Pseubrom, Bromfenex, Pseubrom-PD, Lodrane LD, Shellcap PD, Nalfed PD, Respahist, Ultrabrom PD, Iofed PD, Nalfed, Touro Allergy, Brovex SR, Bromhist-NR, Dimaphen, LoHist-PD, J-TanD PD, LoHist-12D, Di-Bromm, Unit-Hist Drops, Bromaxefed RF Syrup, Andehist NR Syrup, Sildec, Bromhist Pediatric Drops, Unit-Tex 10/120 ER, AccuHist Pediatric, Allent, Shellcap, RespaHist II, Decon-A, Brotapp PE, Tanabid SR, Vazobid-PD, P-Hist DM Drops, Alenaze-D, Brohist D, Ru-Hist D, Vazotab, Zotex-PE, V-HIST, Brom Tann PE, J-Tan D SR, Dime Time Extended Release, Dibrom, BroveX PSB, BroveX PD, B-Vex PD, Bromhist Pediatric, Touro A&H, Endafed, BroveX PSE, Lodrane 12D, Myphetapp, Altatapp, LoHist PSB, Brofed, Bidhist-D, Bromfed SR, Dimetane Decongestant, Andehist DM NR Syrup, Poly-Histine CS, Myphetane DC, Trihist-CS, Liquihistine CS, Polytine CS, Poly CS, Dimetane DC, Poly-Tussin AC, BroveX CBX, BroveX CB, EndaCof-AC, BroveX PB C, TL-Hist CD, BroveX PB CX, M-End WC, Mesehist WC, Histacol DM Pediatric Syrup, Pediahist DM Syrup, BroveX PB DM, BPM DM PHEN, Alacol DM, Duravent DPB, Bromhist-DM, AccuHist DM Pediatric Syrup, Allanhist PDX Syrup, Uni-Hist PDX Syrup, EndaCof-PD, Bromhist-PDX, Uni-Hist DM Pediatric Syrup, Acutuss DM Pediatric, Nalex AC, SymPak II, LoHist-12, B-Vex, VaZol, Lodrane 12 Hour, J-Tan, Brovex, Cophene B, Histaject, Bromaphen, Comtrex Acute Head Cold, J-Tan PD, Tanacof-XR, Veltane, Prop-A-Tane, Brovex CT, Nasahist B, BetaTan, V-COF, Vazotan, Pulmari, Dicel CD, Seradex, Trexbrom (old formulation), Lodrane XR, Dimetapp Allergy, ND-Stat, Siltane, Respa BR, Bidhist, BP Allergy DM, Presgen B, Dallergy DM, Neo DM Syrup, Bromanate DX Cough, Bromatane DX, Bromophed-DX, Myphetane DX Cough, Bromdex D, Anaplex DMX, PediaHist DM, AccuHist DM Pediatric Drops, BroveX PSE DM Tablets, BroveX PSE DM, BroveX PSB DM, PBM Allergy, Liquiphed DM, Anaplex DM, Q-Tapp DM, Pediahist DM Drops, Bromph DM, Uni-Hist PDX Drops, Histacol BD Drops, Allanhist PDX Drops, Bromhist-DM Drops, Bromplex DM, Bromtapp-DM, Bromphenex DM, Bromaxefed DM RF Syrup, PSE Brom DM, Uni-Hist DM Pediatric Drops, Bromaline DM, EndaCof PD Drops, Durahistine DM, LoHist PEB DM, BPM PE DM, Balacall DM, Brotapp PE-DM, DuraTan DM, Bromatan-DM, BroveX PEB DM, Cold & Cough Childrens, TL-Hist DM, Y-COF DMX, Tusdec-DM, Bromtuss DM, Dimaphen DM, Dur-Tann DM, EndaCof-DM, AP-Hist DM, Uni Multihist DM, KG Hist DM, Liquihistine DM, Trihist DM, DM Cold and Cough, Poly Histine DM, Iohist DM, Polytine DM, Prohistine DM, Histinex DM, Poly DM, Highland DM, Delhistine DM, Brom Tann

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

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Administrative Information

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