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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Dimetapp Children's Cold & Cough, Dimetapp Elixir, Dimetane Extentab, Rynex DM, Dimetapp Children's Cold & Allergy, Bromax, Bromatane DX, Show all 280 »Ala-Hist, Alahist DM, Dimetane DX, Poly-Tussin AC, Lodrane D, Cophene B, Bromfed-PD Capsules, Q-Tapp DM, Brotapp-DM, LoHist-12D, Brofed, Poly-Tussin DHC, Bromfenex, Lodrane 24D, Dimetapp DM, M-End WC, Tussi-Pres B, Brotapp PE-DM, Bromdex D, Poly Histine DM, Dibrom, Bromaline, Lodrane, Decon-A, Robitussin Allergy & Cough, Lodrane Liquid, Q-Tapp, RespaHist II, M-End PE, Rynex PE, Dimetapp Allergy, VasoTuss HC, M-END, Dimaphen Elixir, Bromaphen, B-Vex D, P-Hist DM Drops, Sildec DM, Centussin DHC, Rhinabid PD, BPM PE, Bromaphedrine D, Carbodex DM Syrup, Alenaze-D NR, LoHist PEB, BroveX-D, J-Tan D, Dimetane Decongestant, Entre-B, Alacol, VaZol-D, VazoBid, BroveX PB, ProHist DM, Bromfenex PE Pediatric, EndaCof-DH, Bromcomp HC, Visvex, Bromph HD, Bromplex HD, Endacof HC, Brovex HC, J-Tan D HC, SymTan A, Vazotab, Anaplex HD, Drocon-CS, Tusnel-HC, Ala-Hist D, J-Cof DHC, Rhinabid, BPM PE HC, Canges-HC NR, Canges-HC, VazoTuss HC, FluTuss HC, Bromfenex PE, Tanabid SR, Histex SR, Bromfenex PD, M-Hist TD, Ultrabrom, Pseubrom, Iofed, Pseubrom-PD, Ultrabrom PD, Shellcap PD, Allent, Lodrane LD, Nalfed PD, Iofed PD, Respahist, Nalfed, Touro Allergy, Brotapp, Bromhist-NR, Brovex SR, Dimaphen, J-TanD PD, LoHist-PD, Di-Bromm, Unit-Hist Drops, Bromaxefed RF Syrup, Andehist NR Syrup, Sildec, Bromhist Pediatric Drops, Unit-Tex 10/120 ER, AccuHist Pediatric, Shellcap, Touro A&H, Alenaze-D, Brohist D, Brotapp PE, Brom Tann, Vazobid-PD, Seradex-LA, Brom Tann PE, J-Tan D SR, Ru-Hist D, BroveX PEB, Zotex-PE, V-HIST, Phenyl 15/12mg, Phenyl 7.5/6mg, Dime Time Extended Release, ENT, BroveX PD, BroveX PSE, BroveX PSB, B-Vex PD, Endafed, Bromhist Pediatric, Rynex PSE, Lodrane 12D, Myphetapp, Altatapp, LoHist PSB, Bromfed PD, Bidhist-D, Bromfed SR, BroveX ADT, Bromtapp-DM, Trihist-CS, Poly-Histine CS, Myphetane DC, Liquihistine CS, Poly CS, Mar-cof BP, Polytine CS, Dimetane DC, TL-Hist CD, BroveX CB, Nalex AC, BroveX CBX, EndaCof-AC, BroveX PB CX, BroveX PB C, Rydex, Mesehist WC, Pediahist DM Syrup, Bromhist-DM, Histacol DM Pediatric Syrup, BroveX PB DM, Duravent DPB, BPM DM PHEN, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Uni-Hist PDX Syrup, AccuHist PDX Syrup, Allanhist PDX Syrup, EndaCof-PD, Acutuss DM Pediatric, Bromhist-PDX, SymPak II, Dicel CD, B-Vex, Codimal A, LoHist-12, VaZol, Lodrane 24, Lodrane 12 Hour, Histaject, Veltane, Dristan Cold Maximum Strength, Comtrex Acute Head Cold, P-Tex, J-Tan PD, Prop-A-Tane, Tanacof-XR, Brovex, J-Tan, BetaTan, V-COF, Vazotan, Pulmari, Trexbrom, Seradex, Trexbrom (old formulation), Lodrane XR, Nasahist B, Brovex CT, ND-Stat, Siltane, Bidhist, Respa BR, Alacol DM, BP Allergy DM, Bromanate DX Cough, Myphetane DX, Myphetane DX Cough, Bromophed-DX, Brometane DX, Liquiphed DM, Dallergy DM, Neo DM Syrup, BroveX PSE DM, BroveX PSE DM Tablets, PBM Allergy, BroveX PSB DM, BromTann/DM Tann/PSE Tann, Anaplex DMX, Bromadine-DM, Anaplex DM, Bromhist-DM Drops, Bromplex DM, Pediahist DM Drops, Bromph DM, Allanhist PDX Drops, Uni-Hist PDX Drops, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, Andehist DM NR Syrup, Bromphenex DM, Staflex, Bromaxefed DM RF Syrup, Bromaline DM, PSE Brom DM, PediaHist DM, AccuHist DM Pediatric Drops, LoHist PEB DM, BPM PE DM, Balacall DM, Lohist-DM, DuraTan DM, Bromatan-DM, BroveX PEB DM, Cold & Cough Childrens, TL-Hist DM, Presgen B, Tusdec-DM, Bromtuss DM, Dimaphen DM, Dur-Tann DM, EndaCof-DM, AP-Hist DM, Liquihistine DM, Uni Multihist DM, Trihist DM, DM Cold and Cough, EndaCof PD Drops, Durahistine DM, KG Hist DM, Iohist DM, Prohistine DM, Histinex DM, Poly DM, Highland DM, Polytine DM, Delhistine DM, Histacol BD Drops

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

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Administrative Information

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