Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Resperal-DM, Bromfed, Dimetapp Children's Cold & Cough, Dimetapp Elixir, J-Tan, Lodrane 24, Rynex DM, Alahist DM, Lodrane 12D, Show all 267 »Lodrane D, DM Cold and Cough, Mar-cof BP, Bidhist-D, Bromaxefed DM RF Syrup, Dimetane DX, Lohist-DM, Bromaline, Brovex, Sildec, Bromaphen, BroveX-D, M-End PE, Dimetapp Children's Cold & Allergy, B-Vex D, Bromaphedrine D, Lodrane, LoHist-12D, TL-Hist DM, Lodrane 24D, M-End WC, Alenaze-D, Allent, BroveX ADT, ENT, Respa BR, Bromax, J-Cof DHC, J-Tan PD, Dimetane Extentab, Ala-Hist, Lodrane 12 Hour, Dimetapp Allergy, M-END, Histinex DM, Brometane DX, Bromadine-DM, Q-Tapp DM, Brotapp-DM, Bromophed-DX, Seradex, Vazotan, Phenyl 7.5/6mg, Phenyl 15/12mg, J-Tan D SR, Dimetane Decongestant, Brom Tann PE, Bromfenex PE, Drocon-CS, SymTan A, Brovex HC, Anaplex HD, Bromplex HD, Visvex, Bromph HD, VazoTuss HC, FluTuss HC, Tusnel-HC, Ala-Hist D, Canges-HC, VasoTuss HC, Canges-HC NR, BPM PE HC, Bromcomp HC, J-Tan D HC, Alenaze-D NR, BPM PE, Rhinabid PD, VaZol-D, Dimaphen Elixir, Alacol, VazoBid, Bromfed-PD Capsules, Bromfenex PE Pediatric, Decon-A, Endacof HC, J-Tan D, Rhinabid, Seradex-LA, Zotex-PE, BroveX PEB, Myphetapp, Bromhist Pediatric Drops, Q-Tapp, AccuHist Pediatric, Unit-Tex 10/120 ER, Di-Bromm, Unit-Hist Drops, Bromaxefed RF Syrup, Andehist NR Syrup, Pseubrom, Iofed, Lodrane Liquid, Nalfed, Touro Allergy, Bromhist-NR, Brovex SR, Brotapp, Rynex PSE, Brofed, Bromfed PD, Bromfed SR, LoHist PSB, BroveX PSE, J-TanD PD, LoHist-PD, BroveX PD, BroveX PSB, B-Vex PD, Ultrabrom, M-Hist TD, Brotapp PE, Brohist D, LoHist PEB, Dime Time Extended Release, Altatapp, Dibrom, Rynex PE, Vazobid-PD, RespaHist II, BroveX PB, Tanabid SR, Entre-B, V-HIST, Bromfenex, Histex SR, Iofed PD, Respahist, Ultrabrom PD, Pseubrom-PD, Bromfenex PD, Nalfed PD, Lodrane LD, Endafed, Bromhist Pediatric, Touro A&H, Shellcap, Shellcap PD, Vazotab, Dallergy DM, EndaCof-PD, Allanhist PDX Syrup, Acutuss DM Pediatric, Uni-Hist DM Pediatric Syrup, Bromhist-DM, AccuHist DM Pediatric Syrup, Uni-Hist PDX Syrup, AccuHist PDX Syrup, Liquihistine CS, Trihist-CS, Poly CS, Polytine CS, Bromhist-PDX, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Cold & Cough Childrens, Dimaphen DM, BroveX PEB DM, Duravent DPB, BroveX PB DM, BPM PE DM, Dur-Tann DM, Bromtuss DM, Alacol DM, BP Allergy DM, Bromatan-DM, DuraTan DM, Tusdec-DM, Poly-Histine CS, Myphetane DC, Tanacof-XR, P-Tex, B-Vex, LoHist-12, Pulmari, BetaTan, Lodrane XR, Bidhist, VaZol, Dristan Cold Maximum Strength, Brovex CT, Veltane, Siltane, Trexbrom (old formulation), V-COF, BroveX PB C, Poly-Tussin AC, BroveX PB CX, TL-Hist CD, Dimetane DC, BroveX CBX, BroveX CB, Dicel CD, Trexbrom, SymPak II, Nalex AC, EndaCof-AC, Balacall DM, Tussi-Pres B, Histacol BD Drops, Allanhist PDX Drops, Brom Tann, ProHist DM, Sildec DM, P-Hist DM Drops, Robitussin Allergy & Cough, Uni-Hist PDX Drops, Bromplex DM, Uni-Hist DM Pediatric Drops, Bromhist-DM Drops, Pediahist DM Drops, Bromph DM, Comtrex Acute Head Cold, EndaCof-DM, Bromtapp-DM, Bromphenex DM, PSE Brom DM, Dimetapp DM, EndaCof-DH, Poly-Tussin DHC, EndaCof PD Drops, Carbodex DM Syrup, BroveX PSE DM Tablets, Neo DM Syrup, BroveX PSE DM, PBM Allergy, Bromdex D, Carbofed DM Syrup, Bromaline DM, Iohist DM, Polytine DM, KG Hist DM, Uni Multihist DM, Trihist DM, Liquihistine DM, Delhistine DM, Highland DM, AP-Hist DM, Brotapp PE-DM, BPM DM PHEN, Prohistine DM, Poly DM, Poly Histine DM, Durahistine DM, Myphetane DX Cough, Bromatane DX, Liquiphed DM, Anaplex DM, Andehist DM NR Syrup, Bromanate DX Cough, Myphetane DX, AccuHist DM Pediatric Drops, BroveX PSB DM, PediaHist DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Centussin DHC

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Possible Effects on Lactation

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

Substance Name

Brompheniramine

CAS Registry Number

86-22-6

Drug Class

Administrative Information

LactMed Record Number

34

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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