Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Lodrane, Bromfed, Resperal-DM, Brovex, Alahist DM, Lodrane 24D, Lodrane 24, Dimetapp Children's Cold & Allergy, Dimetapp Children's Cold & Cough, Show all 249 »Carbofed DM Syrup, BroveX PSE DM Tablets, TL-Hist DM, Sildec, Vazotan, Tusnel, LoHist-12D, Bromaline, VazoBid, BroveX PEB DM, BPM PE DM, Poly-Tussin DHC, BroveX PSB DM, M-END, BroveX PSE, Bromax, Dimetapp Allergy, LoHist-12, M-End PE, Lodrane 12D, Anaplex DM, Brometane DX, Bromfenex, Trexbrom, Lodrane 12 Hour, Q-Tapp, Lodrane D, Bromfed-PD Capsules, Dimetapp Elixir, Dimetane Extentab, Dicel CD, J-Tan D, J-Cof DHC, PSE Brom DM, Vazotab, Bromhist-PDX, Robitussin Allergy & Cough, Bromadine-DM, BroveX PSE DM, M-End WC, Sildec DM, Dimetane DX, Veltane, BroveX PSB, Ala-Hist D, Tusnel-HC, J-Tan, Q-Tapp DM, DM Cold and Cough, Histinex DM, Mar-cof BP, Bromaline DM, Ala-Hist, Pediahist DM Syrup, Dimaphen Elixir, Dimetane Decongestant, AccuHist PDX Syrup, Decon-A, Poly-Tussin AC, Alenaze-D, J-Tan D SR, Seradex, AccuHist DM Pediatric Drops, Bromphenex DM, RespaHist II, Tanabid SR, Neo DM Syrup, Bromaxefed DM RF Syrup, PediaHist DM, Bromatane DX, Endacof HC, Anaplex DMX, Cold & Cough Childrens, Andehist NR Syrup, Bromfenex PD, Alacol, Allent, BroveX PEB, Seradex-LA, Ultrabrom, ENT, VaZol, Lohist-DM, Dimaphen DM, Nalex AC, V-HIST, Bromhist-DM, Zotex-PE, BroveX-D, Brovex HC, Pulmari, Histacol DM Pediatric Syrup, Dibrom, Uni-Hist DM Pediatric Syrup, P-Hist DM Drops, Bromdex D, Delhistine DM, Myphetapp, Entre-B, BPM PE, Pediahist DM Drops, Anaplex HD, VazoTuss HC, V-COF, Phenyl 15/12mg, Bromplex HD, AccuHist Pediatric, Dime Time Extended Release, Bromplex DM, Bromhist Pediatric Drops, Bromaphen, Histex SR, Respahist, Bidhist-D, Respa BR, Tanacof-XR, Alacol DM, Bromatan-DM, BromTann/DM Tann/PSE Tann, Bromophed-DX, Andehist DM NR Syrup, Brovex CT, LoHist-PD, Bromhist-NR, BroveX PD, J-TanD PD, Brovex SR, Bromhist Pediatric, Endafed, Lodrane Liquid, Touro Allergy, Touro A&H, Shellcap, B-Vex PD, Pseubrom, Nalfed PD, Lodrane LD, Shellcap PD, Iofed, Di-Bromm, Unit-Hist Drops, BroveX ADT, VaZol-D, Alenaze-D NR, Bromaphedrine D, Brom Tann PE, Phenyl 7.5/6mg, Altatapp, Bromaxefed RF Syrup, BroveX PB, B-Vex D, Rhinabid PD, Unit-Tex 10/120 ER, Nalfed, Ultrabrom PD, Pseubrom-PD, M-Hist TD, Bromfenex PE Pediatric, Bromfenex PE, Rhinabid, Iofed PD, Liquiphed DM, EndaCof-PD, Acutuss DM Pediatric, AccuHist DM Pediatric Syrup, Allanhist PDX Syrup, Uni-Hist PDX Syrup, Liquihistine CS, Poly CS, Polytine CS, BP Allergy DM, DuraTan DM, Balacall DM, Prohistine DM, Poly DM, BroveX PB DM, Duravent DPB, Tusdec-DM, Bromtuss DM, Dur-Tann DM, Trihist-CS, Poly-Histine CS, J-Tan PD, B-Vex, BetaTan, P-Tex, Lodrane XR, Dristan Cold Maximum Strength, Siltane, Bidhist, SymPak II, EndaCof-AC, TL-Hist CD, Dimetane DC, Myphetane DC, BroveX PB CX, BroveX PB C, BroveX CB, BroveX CBX, Highland DM, Polytine DM, Bromtapp-DM, EndaCof-DH, Centussin DHC, EndaCof PD Drops, Carbodex DM Syrup, Dallergy DM, EndaCof-DM, PBM Allergy, Canges-HC, VasoTuss HC, Bromph HD, Visvex, Bromcomp HC, Drocon-CS, SymTan A, BPM PE HC, Canges-HC NR, FluTuss HC, ProHist DM, Brom Tann, Poly Histine DM, Durahistine DM, Myphetane DX, Trihist DM, Liquihistine DM, Iohist DM, KG Hist DM, Uni Multihist DM, Bromanate DX Cough, Myphetane DX Cough, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Bromph DM, Bromhist-DM Drops, Comtrex Acute Head Cold, Uni-Hist DM Pediatric Drops, J-Tan D HC

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Possible Effects on Lactation

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

Substance Name

Brompheniramine

CAS Registry Number

86-22-6

Drug Class

• Antihistamines

Administrative Information

LactMed Record Number

34

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2010-12-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

• Brompheniramine use during Pregnancy
• Brompheniramine 12-Hour Sustained-Release Tablets Consumer Information
• Breastfeeding Support Group
• Safe Medications during Breastfeeding
• Medicine use while Breastfeeding
• Medicine use during Pregnancy

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.