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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Dimetapp Elixir, Dimetapp Children's Cold & Cough, Resperal-DM, Rynex DM, Alahist DM, Dimetapp DM, ENT, Brotapp-DM, Show all 283 »Bromaline, Dimetapp Children's Cold & Allergy, AccuHist DM Pediatric Drops, Dimetane DX, Lohist-DM, Dimaphen Elixir, Bromadine-DM, Pseubrom-PD, Lodrane, Pseubrom, Lodrane 24D, BroveX PSB DM, BromTann/DM Tann/PSE Tann, Bromatan-DM, Bromax, Dimetapp Allergy, M-END, Dristan Cold Maximum Strength, Lodrane 24, P-Tex, Bromhist Pediatric, Lodrane D, Shellcap, Brotapp, Neo DM Syrup, LoHist-12, M-End WC, Brovex, Dimetane Extentab, M-End PE, DM Cold and Cough, Robitussin Allergy & Cough, Dimetane Decongestant, Tussi-Pres B, Dimaphen DM, Seradex, Poly Histine DM, Dime Time Extended Release, Presgen B, Bromhist-DM, BroveX PEB, Histaject, Rynex PE, VazoBid, Decon-A, LoHist PEB, VaZol-D, Alenaze-D NR, Bromaphedrine D, B-Vex D, BroveX PB, Alacol, BroveX-D, BPM PE, Relhist BP, Entre-B, J-Tan D, Rhinabid PD, Canges-HC NR, BPM PE HC, FluTuss HC, VazoTuss HC, Canges-HC, VasoTuss HC, Tusnel-HC, EndaCof-DH, Poly-Tussin DHC, J-Cof DHC, Ala-Hist, Ala-Hist D, Drocon-CS, Anaplex HD, Rhinabid, J-Tan D HC, Bromfenex PE, Bromfenex PE Pediatric, Bromfed-PD Capsules, SymTan A, Brovex HC, Bromph HD, Bromplex HD, Visvex, Bromcomp HC, Endacof HC, Vazotab, Dibrom, M-Hist TD, Histex SR, Ultrabrom, Iofed, Nalfed, Lodrane Liquid, Bromfenex PD, Bromfenex, Lodrane LD, Shellcap PD, Nalfed PD, Respahist, Ultrabrom PD, Iofed PD, Touro Allergy, Andehist NR Syrup, Brovex SR, Bromhist-NR, Dimaphen, LoHist-PD, J-TanD PD, LoHist-12D, Di-Bromm, Unit-Hist Drops, Sildec, Bromaxefed RF Syrup, Q-Tapp, Bromhist Pediatric Drops, Unit-Tex 10/120 ER, AccuHist Pediatric, Allent, Touro A&H, RespaHist II, Alenaze-D, Brotapp PE, Tanabid SR, Vazobid-PD, Seradex-LA, Brohist D, Brom Tann PE, Zotex-PE, Ru-Hist D, V-HIST, Phenyl 7.5/6mg, J-Tan D SR, Phenyl 15/12mg, Centussin DHC, Altatapp, BroveX PSE, Rynex PSE, BroveX PD, BroveX PSB, Endafed, B-Vex PD, Lodrane 12D, Bidhist-D, LoHist PSB, Myphetapp, Brofed, Bromfed PD, Bromfed SR, BroveX ADT, Bromaxefed DM RF Syrup, Poly CS, Liquihistine CS, Polytine CS, Mar-cof BP, Mesehist WC, Rydex, Trihist-CS, Poly-Histine CS, BroveX PB CX, BroveX PB C, TL-Hist CD, Poly-Tussin AC, Myphetane DC, Dimetane DC, AccuHist PDX Syrup, Uni-Hist PDX Syrup, BroveX PB DM, Niva-Hist DM, BPM DM PHEN, Duravent DPB, BP Allergy DM, Alacol DM, Histacol DM Pediatric Syrup, Pediahist DM Syrup, EndaCof-PD, Allanhist PDX Syrup, Bromhist-PDX, Acutuss DM Pediatric, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, EndaCof-AC, BroveX CBX, VaZol, B-Vex, Lodrane 12 Hour, J-Tan, Nasahist B, Brovex CT, Cophene B, Codimal A, Bromaphen, Comtrex Acute Head Cold, J-Tan PD, Tanacof-XR, Veltane, Prop-A-Tane, ND-Stat, Siltane, Trexbrom, Pulmari, Dicel CD, SymPak II, BroveX CB, Nalex AC, Vazotan, BetaTan, Bidhist, Respa BR, Lodrane XR, Trexbrom (old formulation), V-COF, Y-COF DMX, TL-Hist DM, Bromphenex DM, Anaplex DM, Andehist DM NR Syrup, Bromtapp-DM, PSE Brom DM, Staflex, Brometane DX, Liquiphed DM, Myphetane DX, Dallergy DM, Bromanate DX Cough, Bromatane DX, Bromophed-DX, Myphetane DX Cough, Bromaline DM, Carbofed DM Syrup, Histacol BD Drops, Allanhist PDX Drops, Brom Tann, ProHist DM, Carbodex DM Syrup, P-Hist DM Drops, Uni-Hist PDX Drops, Bromph DM, Bromplex DM, Uni-Hist DM Pediatric Drops, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Bromdex D, Anaplex DMX, DuraTan DM, Brotapp PE-DM, EndaCof-DM, AP-Hist DM, Prohistine DM, Histinex DM, Balacall DM, LoHist PEB DM, Bromtuss DM, Tusdec-DM, Dur-Tann DM, Cold & Cough Childrens, BPM PE DM, BroveX PEB DM, Poly DM, Highland DM, EndaCof PD Drops, Durahistine DM, PediaHist DM, BroveX PSE DM Tablets, PBM Allergy, BroveX PSE DM, Trihist DM, Liquihistine DM, Polytine DM, Delhistine DM, Iohist DM, KG Hist DM, Uni Multihist DM, Sildec DM

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

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Administrative Information

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