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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Resperal-DM, Bromfed, Dimetapp Elixir, Dimetane Extentab, Rynex DM, Dimetapp Children's Cold & Allergy, Dimetane Decongestant, Dimetapp Children's Cold & Cough, Robitussin Allergy & Cough, Show all 281 »Shellcap, Seradex, ENT, Dimetane DX, Bromax, Ala-Hist, VazoTuss HC, Cophene B, Duravent DPB, Q-Tapp, Tussi-Pres B, Lodrane, J-Tan D SR, Decon-A, Dimaphen Elixir, Sildec, Bromaline, Mar-cof BP, Brofed, BroveX PSE, Dibrom, Rynex PE, Brotapp-DM, Bromfed-PD Capsules, Carbofed DM Syrup, Q-Tapp DM, Centussin DHC, LoHist-PD, J-Tan D, Brotapp PE-DM, Liquihistine DM, Seradex-LA, RespaHist II, Alahist DM, Bromatan-DM, M-End PE, BroveX CB, Unit-Hist Drops, Di-Bromm, Unit-Tex 10/120 ER, AccuHist Pediatric, Bromhist Pediatric Drops, Bromhist-NR, Brotapp, SymTan A, Brovex HC, J-Tan D HC, Dimaphen, Brovex SR, Bromaxefed RF Syrup, Andehist NR Syrup, Ultrabrom, Iofed, M-Hist TD, Rhinabid, Bromfenex PE, Pseubrom, Rhinabid PD, Endacof HC, Touro Allergy, Nalfed, Lodrane Liquid, Bromfenex PE Pediatric, Visvex, EndaCof-DH, Poly-Tussin DHC, J-Cof DHC, LoHist-12D, Ala-Hist D, J-TanD PD, Sildec DM, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Tusnel-HC, Lodrane 24D, Anaplex HD, Drocon-CS, Bromplex HD, Bromph HD, BPM PE, M-END, Canges-HC, VasoTuss HC, BPM PE HC, Canges-HC NR, FluTuss HC, Bromcomp HC, Bromaphedrine D, Lodrane LD, Nalfed PD, Altatapp, Myphetapp, Shellcap PD, Dime Time Extended Release, Vazobid-PD, Ultrabrom PD, Iofed PD, Respahist, Tanabid SR, Allent, Touro A&H, Bromfed SR, Bromfed PD, Bidhist-D, Lodrane 12D, Rynex PSE, LoHist PSB, BroveX PD, Endafed, Bromhist Pediatric, B-Vex PD, BroveX PSB, Pseubrom-PD, Bromfenex, Entre-B, Alacol, LoHist PEB, BroveX-D, Vazotab, BroveX PB, VazoBid, Lodrane D, Histex SR, Alenaze-D NR, VaZol-D, BroveX ADT, BroveX PEB, Alenaze-D, Brohist D, Brotapp PE, Histacol BD Drops, Bromfenex PD, Brom Tann PE, Phenyl 15/12mg, Ru-Hist D, Zotex-PE, V-HIST, Phenyl 7.5/6mg, B-Vex D, Andehist DM NR Syrup, Poly-Histine CS, Myphetane DC, Dimetane DC, Trihist-CS, Liquihistine CS, Polytine CS, Poly CS, Poly-Tussin AC, TL-Hist CD, Nalex AC, SymPak II, BroveX CBX, EndaCof-AC, BroveX PB CX, BroveX PB C, M-End WC, Rydex, Bromhist-DM, AccuHist DM Pediatric Syrup, Pediahist DM Syrup, Histacol DM Pediatric Syrup, BPM DM PHEN, BroveX PB DM, Uni-Hist DM Pediatric Syrup, Acutuss DM Pediatric, AccuHist PDX Syrup, Mesehist WC, Uni-Hist PDX Syrup, Allanhist PDX Syrup, Bromhist-PDX, EndaCof-PD, Dicel CD, Trexbrom, Codimal A, Histaject, B-Vex, LoHist-12, Lodrane 12 Hour, VaZol, Veltane, Prop-A-Tane, Dristan Cold Maximum Strength, Comtrex Acute Head Cold, P-Tex, Bromaphen, Tanacof-XR, J-Tan PD, Lodrane 24, Brovex, Trexbrom (old formulation), Lodrane XR, V-COF, BetaTan, Pulmari, Vazotan, Bidhist, Respa BR, Brovex CT, J-Tan, Nasahist B, ND-Stat, Siltane, Dimetapp Allergy, Alacol DM, BP Allergy DM, Myphetane DX, Dallergy DM, Neo DM Syrup, Bromanate DX Cough, Bromatane DX, Bromophed-DX, Myphetane DX Cough, Bromdex D, BromTann/DM Tann/PSE Tann, BroveX PSE DM Tablets, PediaHist DM, BroveX PSE DM, PBM Allergy, Anaplex DMX, BroveX PSB DM, Liquiphed DM, Brometane DX, Bromplex DM, Uni-Hist DM Pediatric Drops, Bromhist-DM Drops, Pediahist DM Drops, Uni-Hist PDX Drops, Bromph DM, Bromaline DM, PSE Brom DM, Anaplex DM, Bromadine-DM, Bromphenex DM, Staflex, Bromaxefed DM RF Syrup, Bromtapp-DM, AccuHist DM Pediatric Drops, EndaCof PD Drops, BPM PE DM, BroveX PEB DM, LoHist PEB DM, Balacall DM, DuraTan DM, Lohist-DM, Cold & Cough Childrens, Dimaphen DM, Y-COF DMX, Presgen B, TL-Hist DM, Tusdec-DM, Dur-Tann DM, Bromtuss DM, EndaCof-DM, AP-Hist DM, Trihist DM, Uni Multihist DM, Poly Histine DM, DM Cold and Cough, Dimetapp DM, Durahistine DM, KG Hist DM, Iohist DM, Prohistine DM, Histinex DM, Poly DM, Highland DM, Polytine DM, Delhistine DM, Allanhist PDX Drops

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

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Administrative Information

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