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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Dimetapp Elixir, Resperal-DM, Dimetapp Children's Cold & Cough, Alahist DM, Rynex DM, Dimetapp Children's Cold & Allergy, Dimetane DX, Robitussin Allergy & Cough, Show all 281 »Dimetapp Allergy, M-END, Rynex PE, Dimetapp DM, Q-Tapp, DM Cold and Cough, Poly Histine DM, ND-Stat, Brovex, Tussi-Pres B, TL-Hist DM, M-End PE, Brotapp-DM, Sildec, Bromadine-DM, Bromophed-DX, Q-Tapp DM, Visvex, Bromaline, Shellcap, Brotapp, M-End WC, Brovex HC, Bromhist Pediatric, Mar-cof BP, Lodrane, Lohist-DM, ENT, Cophene B, Dimetane Extentab, Pediahist DM Syrup, Myphetapp, BromTann/DM Tann/PSE Tann, AccuHist PDX Syrup, Bromaphedrine D, Decon-A, Bromphenex DM, Pulmari, Bromanate DX Cough, Poly-Tussin DHC, VaZol-D, Alenaze-D NR, B-Vex D, SymTan A, Dimaphen Elixir, Endacof HC, J-Tan D HC, VazoBid, Sildec DM, J-Tan D, Dimetane Decongestant, Vazotab, Centussin DHC, BroveX-D, BroveX PB, Alacol, Entre-B, LoHist PEB, EndaCof-DH, BPM PE, Canges-HC NR, BPM PE HC, VasoTuss HC, Bromfed-PD Capsules, FluTuss HC, VazoTuss HC, BroveX ADT, Drocon-CS, Canges-HC, Bromfenex PE Pediatric, Bromfenex PE, Bromplex HD, Ala-Hist, Rhinabid PD, Bromph HD, Ala-Hist D, Tusnel-HC, Rhinabid, Bromcomp HC, Anaplex HD, J-Cof DHC, Vazobid-PD, M-Hist TD, Histex SR, Bromfenex PD, Ultrabrom, Iofed, Lodrane Liquid, Pseubrom, Bromfenex, Pseubrom-PD, Lodrane LD, Shellcap PD, Nalfed PD, Respahist, Ultrabrom PD, Iofed PD, Nalfed, Touro Allergy, Dimaphen, Brovex SR, Lodrane 24D, LoHist-PD, J-TanD PD, LoHist-12D, Bromhist-NR, Di-Bromm, Bromaxefed RF Syrup, Andehist NR Syrup, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Hist Drops, Unit-Tex 10/120 ER, Allent, Touro A&H, RespaHist II, Alenaze-D, Brotapp PE, Tanabid SR, Carbodex DM Syrup, Seradex-LA, Brohist D, Brom Tann PE, Zotex-PE, Ru-Hist D, V-HIST, Phenyl 7.5/6mg, J-Tan D SR, Phenyl 15/12mg, Dime Time Extended Release, Dibrom, BroveX PSE, Lodrane D, BroveX PD, BroveX PSB, Endafed, B-Vex PD, Rynex PSE, Lodrane 12D, LoHist PSB, Altatapp, Brofed, Bromfed PD, Bidhist-D, Bromfed SR, BroveX PEB, Bromtapp-DM, Myphetane DC, Dimetane DC, Poly-Histine CS, Trihist-CS, Poly CS, Liquihistine CS, Poly-Tussin AC, TL-Hist CD, BroveX CB, Nalex AC, BroveX CBX, EndaCof-AC, BroveX PB CX, BroveX PB C, Polytine CS, Rydex, Histacol DM Pediatric Syrup, Bromhist-DM, BroveX PB DM, BPM DM PHEN, Alacol DM, Duravent DPB, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Uni-Hist PDX Syrup, Mesehist WC, Allanhist PDX Syrup, EndaCof-PD, Acutuss DM Pediatric, Bromhist-PDX, SymPak II, Dicel CD, Histaject, Veltane, Codimal A, B-Vex, VaZol, LoHist-12, Prop-A-Tane, Tanacof-XR, Dristan Cold Maximum Strength, Comtrex Acute Head Cold, P-Tex, Bromaphen, Bromax, J-Tan PD, Lodrane 12 Hour, Lodrane 24, V-COF, Trexbrom (old formulation), BetaTan, Vazotan, Trexbrom, Seradex, Lodrane XR, Bidhist, Brovex CT, J-Tan, Nasahist B, Siltane, Respa BR, BP Allergy DM, Presgen B, Myphetane DX Cough, Bromatane DX, Liquiphed DM, Brometane DX, Andehist DM NR Syrup, Anaplex DM, Myphetane DX, Dallergy DM, PBM Allergy, BroveX PSE DM, BroveX PSB DM, Anaplex DMX, Neo DM Syrup, Bromdex D, Staflex, Bromaxefed DM RF Syrup, Uni-Hist PDX Drops, Bromph DM, Allanhist PDX Drops, Histacol BD Drops, ProHist DM, Brom Tann, Pediahist DM Drops, Bromhist-DM Drops, Bromaline DM, PSE Brom DM, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, Bromplex DM, BroveX PSE DM Tablets, PediaHist DM, Balacall DM, LoHist PEB DM, Brotapp PE-DM, Bromatan-DM, EndaCof-DM, DuraTan DM, BPM PE DM, BroveX PEB DM, Tusdec-DM, Y-COF DMX, Bromtuss DM, Dur-Tann DM, Cold & Cough Childrens, Dimaphen DM, AP-Hist DM, Histinex DM, Liquihistine DM, Uni Multihist DM, Trihist DM, Durahistine DM, AccuHist DM Pediatric Drops, EndaCof PD Drops, KG Hist DM, Iohist DM, Poly DM, Prohistine DM, Highland DM, Delhistine DM, Polytine DM, P-Hist DM Drops

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

Substance Name

Brompheniramine

CAS Registry Number

86-22-6

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

34

Last Revision Date

20150310

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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