Brompheniramine use while Breastfeeding
Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Rynex DM, Dimetapp Elixir, Dimetapp Children's Cold & Cough, Alahist DM, Dimetane Extentab, Brovex, Bromaline, Show all 261 »Lodrane 24, Anaplex DM, M-End WC, EndaCof-DM, Lodrane, Lodrane 12D, Seradex, VazoBid, Dimetapp DM, Dimaphen DM, Mar-cof BP, Dimetapp Children's Cold & Allergy, Bromfed-PD Capsules, Phenyl 7.5/6mg, J-Tan D SR, Myphetane DC, Lohist-DM, Vazotab, Seradex-LA, M-End PE, Poly-Tussin AC, Histex SR, M-END, TL-Hist DM, Dristan Cold Maximum Strength, Dimetane DX, Veltane, Myphetane DX, Bromhist Pediatric Drops, Histinex DM, Shellcap, Bromadine-DM, Lodrane D, Brotapp PE-DM, Brotapp-DM, Bromtapp-DM, BroveX PSE DM Tablets, BroveX PSE DM, Bromophed-DX, Phenyl 15/12mg, BroveX-D, J-Tan D, BroveX PEB, Decon-A, Dicel CD, Siltane, Visvex, Trexbrom, Rynex PE, Pulmari, Brohist D, AccuHist PDX Syrup, BPM PE HC, VasoTuss HC, Canges-HC NR, VazoTuss HC, Zotex-PE, Canges-HC, FluTuss HC, Tusnel-HC, Alenaze-D NR, VaZol-D, Bromaphedrine D, B-Vex D, Brovex HC, Rhinabid, Drocon-CS, Bromfenex PE, Endacof HC, Bromfenex PE Pediatric, Rhinabid PD, BPM PE, J-Tan D HC, Alenaze-D, Anaplex HD, Dimaphen Elixir, Bromplex HD, Bromph HD, Bromcomp HC, SymTan A, Altatapp, Bromaxefed RF Syrup, Andehist NR Syrup, Sildec, Q-Tapp, Unit-Tex 10/120 ER, AccuHist Pediatric, Touro Allergy, Nalfed, Ultrabrom, M-Hist TD, Iofed, Pseubrom, Lodrane Liquid, Unit-Hist Drops, Di-Bromm, B-Vex PD, BroveX PSB, BroveX PSE, LoHist PSB, Brotapp, Rynex PSE, BroveX PD, J-TanD PD, Brovex SR, Bromhist-NR, Lodrane 24D, LoHist-PD, LoHist-12D, Bromfenex PD, Pseubrom-PD, Vazobid-PD, V-HIST, Brotapp PE, Dime Time Extended Release, ENT, Dibrom, Entre-B, Tanabid SR, Brom Tann PE, BroveX ADT, Dimetane Decongestant, BroveX PB, RespaHist II, Ala-Hist D, Myphetapp, Nalfed PD, Lodrane LD, Respahist, Iofed PD, Ultrabrom PD, Shellcap PD, Allent, Bidhist-D, Bromfenex, Bromhist Pediatric, Endafed, Touro A&H, Alacol, Allanhist PDX Drops, Allanhist PDX Syrup, Uni-Hist PDX Syrup, EndaCof-PD, Acutuss DM Pediatric, Uni-Hist DM Pediatric Syrup, Bromhist-PDX, Polytine CS, Poly-Histine CS, Dimetane DC, Trihist-CS, Liquihistine CS, Poly CS, AccuHist DM Pediatric Syrup, Bromhist-DM, Dur-Tann DM, Bromtuss DM, Cold & Cough Childrens, BroveX PEB DM, Duravent DPB, Tusdec-DM, DuraTan DM, Histacol DM Pediatric Syrup, Pediahist DM Syrup, BP Allergy DM, Alacol DM, Bromatan-DM, TL-Hist CD, BroveX PB CX, P-Tex, Lodrane XR, Bromaphen, J-Tan PD, Respa BR, Bidhist, Dimetapp Allergy, VaZol, Comtrex Acute Head Cold, Lodrane 12 Hour, J-Tan, Brovex CT, Tanacof-XR, B-Vex, EndaCof-AC, Nalex AC, BroveX CB, BroveX CBX, BroveX PB C, SymPak II, V-COF, Bromax, LoHist-12, BetaTan, Vazotan, Trexbrom (old formulation), BPM PE DM, BroveX PB DM, Robitussin Allergy & Cough, Uni-Hist PDX Drops, Histacol BD Drops, Brom Tann, ProHist DM, Bromph DM, Q-Tapp DM, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, P-Hist DM Drops, Sildec DM, Poly-Tussin DHC, PSE Brom DM, EndaCof-DH, Centussin DHC, J-Cof DHC, Bromphenex DM, EndaCof PD Drops, Neo DM Syrup, Dallergy DM, PBM Allergy, Bromdex D, Carbodex DM Syrup, Bromaline DM, Bromaxefed DM RF Syrup, KG Hist DM, Iohist DM, Uni Multihist DM, Liquihistine DM, Trihist DM, Polytine DM, Delhistine DM, Tussi-Pres B, Balacall DM, Prohistine DM, Poly DM, Highland DM, Poly Histine DM, DM Cold and Cough, Myphetane DX Cough, Bromatane DX, Liquiphed DM, Brometane DX, Andehist DM NR Syrup, Bromanate DX Cough, BromTann/DM Tann/PSE Tann, BroveX PSB DM, Durahistine DM, AccuHist DM Pediatric Drops, PediaHist DM, Anaplex DMX, Ala-Hist
Brompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Possible Effects on Lactation
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
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LactMed Record Number
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
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