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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Dimetapp Elixir, Rynex DM, Dimetapp Children's Cold & Cough, Dimetane Extentab, Bromatane DX, Dimetane Decongestant, Dimetapp Children's Cold & Allergy, Show all 280 »Bromax, Robitussin Allergy & Cough, Dimetane DX, Ala-Hist, Cophene B, Bromfed-PD Capsules, Seradex, Q-Tapp, Shellcap, Brotapp-DM, Alahist DM, Decon-A, Bromfenex, ENT, Poly-Tussin DHC, J-Tan D SR, Bromdex D, Dimetapp DM, Brofed, Brotapp PE-DM, Duravent DPB, Bromatan-DM, Poly Histine DM, Liquihistine DM, Dibrom, M-End PE, Seradex-LA, Mar-cof BP, Sildec, Bromaline, BroveX PSE, RespaHist II, Carbofed DM Syrup, VasoTuss HC, Poly-Tussin AC, Bromaphen, Dimaphen Elixir, BroveX CB, Q-Tapp DM, M-END, J-Tan D, BPM PE, B-Vex D, Rhinabid PD, EndaCof-DH, J-Cof DHC, Bromaphedrine D, Centussin DHC, VazoBid, Alacol, Entre-B, Rynex PE, LoHist PEB, BroveX PB, Carbodex DM Syrup, VaZol-D, Ala-Hist D, Sildec DM, Alenaze-D NR, Bromfenex PE, Bromcomp HC, Visvex, Bromph HD, Endacof HC, Brovex HC, BroveX-D, J-Tan D HC, SymTan A, Bromplex HD, Anaplex HD, Rhinabid, BPM PE HC, Bromfenex PE Pediatric, Canges-HC NR, FluTuss HC, Drocon-CS, Canges-HC, VazoTuss HC, Tusnel-HC, Tanabid SR, Ultrabrom, M-Hist TD, Iofed, Pseubrom, Nalfed, Lodrane Liquid, Histex SR, Bromfenex PD, Nalfed PD, Lodrane LD, Respahist, Iofed PD, Pseubrom-PD, Ultrabrom PD, Touro Allergy, Andehist NR Syrup, Dimaphen, Brovex SR, Lodrane 24D, LoHist-PD, J-TanD PD, LoHist-12D, Brotapp, Bromhist-NR, Bromhist Pediatric Drops, Bromaxefed RF Syrup, AccuHist Pediatric, Unit-Tex 10/120 ER, Di-Bromm, Unit-Hist Drops, Shellcap PD, Allent, Alenaze-D, Brohist D, Brotapp PE, P-Hist DM Drops, Dime Time Extended Release, Vazobid-PD, Brom Tann PE, Phenyl 15/12mg, BroveX PEB, BroveX ADT, Ru-Hist D, Zotex-PE, Phenyl 7.5/6mg, V-HIST, Altatapp, Myphetapp, BroveX PSB, BroveX PD, B-Vex PD, Bromhist Pediatric, Touro A&H, Endafed, Lodrane D, Rynex PSE, LoHist PSB, Lodrane, Bromfed PD, Bromfed SR, Lodrane 12D, Bidhist-D, Vazotab, Andehist DM NR Syrup, Trihist-CS, Poly-Histine CS, Liquihistine CS, Poly CS, M-End WC, Polytine CS, Myphetane DC, Dimetane DC, BroveX CBX, Nalex AC, EndaCof-AC, BroveX PB C, TL-Hist CD, BroveX PB CX, Rydex, Mesehist WC, Pediahist DM Syrup, Bromhist-DM, Histacol DM Pediatric Syrup, BroveX PB DM, Alacol DM, BPM DM PHEN, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Uni-Hist PDX Syrup, AccuHist PDX Syrup, Allanhist PDX Syrup, EndaCof-PD, Acutuss DM Pediatric, Bromhist-PDX, SymPak II, Dicel CD, B-Vex, Codimal A, LoHist-12, VaZol, Lodrane 24, Lodrane 12 Hour, Histaject, Veltane, Dristan Cold Maximum Strength, Comtrex Acute Head Cold, P-Tex, J-Tan PD, Prop-A-Tane, Tanacof-XR, Brovex, J-Tan, V-COF, Trexbrom (old formulation), BetaTan, Vazotan, Trexbrom, Pulmari, Lodrane XR, Bidhist, Nasahist B, Brovex CT, ND-Stat, Dimetapp Allergy, Respa BR, Siltane, BP Allergy DM, Presgen B, Myphetane DX Cough, Bromanate DX Cough, Bromophed-DX, Liquiphed DM, Bromadine-DM, Brometane DX, Myphetane DX, Dallergy DM, PBM Allergy, BroveX PSE DM, BroveX PSB DM, Anaplex DMX, Neo DM Syrup, BromTann/DM Tann/PSE Tann, Anaplex DM, Bromphenex DM, Bromph DM, Pediahist DM Drops, Uni-Hist PDX Drops, Allanhist PDX Drops, Brom Tann, Histacol BD Drops, Bromhist-DM Drops, Bromplex DM, Bromtapp-DM, Staflex, Bromaxefed DM RF Syrup, PSE Brom DM, Uni-Hist DM Pediatric Drops, Bromaline DM, BroveX PSE DM Tablets, PediaHist DM, LoHist PEB DM, BPM PE DM, Balacall DM, Lohist-DM, EndaCof-DM, DuraTan DM, BroveX PEB DM, Cold & Cough Childrens, Tusdec-DM, TL-Hist DM, Bromtuss DM, Dur-Tann DM, Tussi-Pres B, Dimaphen DM, AP-Hist DM, Histinex DM, Trihist DM, Uni Multihist DM, DM Cold and Cough, Durahistine DM, AccuHist DM Pediatric Drops, EndaCof PD Drops, KG Hist DM, Iohist DM, Poly DM, Prohistine DM, Highland DM, Delhistine DM, Polytine DM, ProHist DM

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

Substance Name

Brompheniramine

CAS Registry Number

86-22-6

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

34

Last Revision Date

20150310

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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