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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Resperal-DM, Bromfed, Dimetapp Elixir, Rynex DM, Alahist DM, Dimetapp Children's Cold & Cough, M-End PE, Lodrane, Dimetane DX, Show all 270 »Lodrane D, Dimetane Extentab, Rynex PSE, Lodrane 24D, Dimetapp DM, Robitussin Allergy & Cough, Brovex, Dimaphen DM, Rynex PE, Rhinabid, VazoBid, LoHist-12, Poly-Tussin AC, EndaCof-DM, Brotapp, Brotapp-DM, Q-Tapp, Bromfed PD, Bromaline, Endacof HC, Bromanate DX Cough, DuraTan DM, Lohist-DM, TL-Hist DM, M-End WC, Bromatan-DM, LoHist-12D, Bromfenex, Lodrane LD, J-TanD PD, Bromfed SR, BP Allergy DM, Ala-Hist D, Shellcap, Decon-A, DM Cold and Cough, Bromadine-DM, Poly Histine DM, Histinex DM, ProHist DM, Brometane DX, Tusnel-HC, VaZol, Lodrane 24, Dimetapp Allergy, Respa BR, V-COF, Pulmari, Zotex-PE, Seradex-LA, Dibrom, ENT, Alacol, Bromfed-PD Capsules, Carbodex DM Syrup, Dimetane Decongestant, J-Tan D, BroveX-D, LoHist PEB, BroveX PB, Anaplex HD, Drocon-CS, Bromplex HD, Bromph HD, Bromcomp HC, Visvex, M-END, Canges-HC, BPM PE HC, VasoTuss HC, Canges-HC NR, FluTuss HC, VazoTuss HC, Brovex HC, SymTan A, Alenaze-D NR, Bromaphedrine D, VaZol-D, Dimaphen Elixir, Vazotab, B-Vex D, BPM PE, LoHist-PD, J-Tan D HC, Bromfenex PE, Bromfenex PE Pediatric, Rhinabid PD, Entre-B, Altatapp, M-Hist TD, Histex SR, Ultrabrom, Iofed, Pseubrom, Bromfenex PD, Pseubrom-PD, Nalfed PD, Shellcap PD, Respahist, Iofed PD, Ultrabrom PD, Lodrane Liquid, Nalfed, Di-Bromm, Unit-Hist Drops, Bromhist-NR, Brovex SR, Dimaphen, Unit-Tex 10/120 ER, AccuHist Pediatric, Andehist NR Syrup, Touro Allergy, Bromaxefed RF Syrup, Sildec, Bromhist Pediatric Drops, Allent, Touro A&H, Alenaze-D, Brohist D, RespaHist II, Brotapp PE, Tanabid SR, Brom Tann PE, J-Tan D SR, V-HIST, BroveX PEB, Dimetapp Children's Cold & Allergy, Phenyl 7.5/6mg, Phenyl 15/12mg, Vazobid-PD, Dime Time Extended Release, BroveX PSB, BroveX PD, B-Vex PD, Bromhist Pediatric, Endafed, BroveX PSE, Lodrane 12D, Myphetapp, LoHist PSB, Brofed, Bidhist-D, BroveX ADT, Bromaline DM, Mar-cof BP, Polytine CS, AccuHist PDX Syrup, Uni-Hist PDX Syrup, EndaCof-PD, Allanhist PDX Syrup, Poly CS, Liquihistine CS, Dimetane DC, TL-Hist CD, Myphetane DC, Poly-Histine CS, Trihist-CS, Bromhist-PDX, Acutuss DM Pediatric, Alacol DM, Duravent DPB, Tusdec-DM, Bromtuss DM, Tussi-Pres B, Dur-Tann DM, BPM DM PHEN, BroveX PB DM, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, BroveX PB CX, BroveX PB C, Cophene B, Codimal A, B-Vex, Lodrane 12 Hour, Brovex CT, J-Tan, Veltane, Tanacof-XR, P-Tex, Dristan Cold Maximum Strength, Bromaphen, J-Tan PD, Bromax, Siltane, Bidhist, Nalex AC, SymPak II, BroveX CB, BroveX CBX, EndaCof-AC, Dicel CD, Trexbrom, Trexbrom (old formulation), Lodrane XR, BetaTan, Vazotan, Seradex, Cold & Cough Childrens, BroveX PEB DM, PSE Brom DM, Bromaxefed DM RF Syrup, Comtrex Acute Head Cold, Carbofed DM Syrup, Bromplex DM, Uni-Hist DM Pediatric Drops, Bromtapp-DM, Andehist DM NR Syrup, Bromophed-DX, Myphetane DX Cough, Liquiphed DM, Anaplex DM, Bromphenex DM, Bromhist-DM Drops, Pediahist DM Drops, Centussin DHC, Sildec DM, Poly-Tussin DHC, EndaCof-DH, J-Cof DHC, P-Hist DM Drops, Brom Tann, Bromph DM, Q-Tapp DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Bromatane DX, Myphetane DX, Polytine DM, Delhistine DM, Iohist DM, KG Hist DM, Liquihistine DM, Uni Multihist DM, Highland DM, Poly DM, Balacall DM, BPM PE DM, Brotapp PE-DM, AP-Hist DM, Prohistine DM, Trihist DM, Durahistine DM, BromTann/DM Tann/PSE Tann, Anaplex DMX, Bromdex D, Neo DM Syrup, Dallergy DM, BroveX PSB DM, PBM Allergy, AccuHist DM Pediatric Drops, EndaCof PD Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, Ala-Hist

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

Substance Name

Brompheniramine

CAS Registry Number

86-22-6

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

34

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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