Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Rynex DM, Dimetapp Elixir, Alahist DM, Dimetapp Children's Cold & Cough, Robitussin Allergy & Cough, M-End PE, Dimetane Extentab, Show all 270 »Histacol DM Pediatric Syrup, Rynex PSE, Lodrane D, Q-Tapp, Cold & Cough Childrens, Dimaphen DM, Bromfenex, Rynex PE, Mar-cof BP, Brotapp-DM, Lodrane, Dimetane DX, M-END, Brovex, DM Cold and Cough, J-Tan, J-TanD PD, P-Hist DM Drops, Lodrane 24D, M-End WC, BromTann/DM Tann/PSE Tann, Dallergy DM, J-Tan PD, Brometane DX, Q-Tapp DM, B-Vex PD, Pulmari, Seradex, B-Vex D, J-Tan D, V-COF, J-Cof DHC, J-Tan D HC, Bromaline, Ala-Hist, V-HIST, J-Tan D SR, Ultrabrom PD, Nalex AC, Bromfenex PD, Ultrabrom, Decon-A, Dimetapp Allergy, VaZol, Bromax, Lodrane 24, Anaplex DM, Dimaphen Elixir, VazoBid, Bromfed-PD Capsules, Rhinabid, Ala-Hist D, Alacol, LoHist PEB, ProHist DM, Bromatane DX, Carbodex DM Syrup, Phenyl 7.5/6mg, Dimetapp Children's Cold & Allergy, BroveX PSB DM, Poly Histine DM, Bromfed SR, Shellcap, Poly-Tussin AC, Bromhist-DM, LoHist-12D, AP-Hist DM, DuraTan DM, Lohist-DM, Bidhist, Pseubrom-PD, Nalfed PD, Unit-Hist Drops, Respahist, Histex SR, Iofed PD, M-Hist TD, Rhinabid PD, Alenaze-D NR, VaZol-D, BroveX PB, Bromaphedrine D, BPM PE, Bromfenex PE, Bromfenex PE Pediatric, Iofed, Lodrane LD, Touro Allergy, Bromaxefed RF Syrup, Andehist NR Syrup, Anaplex HD, Bromplex HD, Sildec, Drocon-CS, Canges-HC, AccuHist Pediatric, Bromhist Pediatric Drops, Bromph HD, Visvex, Entre-B, Nalfed, Lodrane Liquid, LoHist-PD, SymTan A, Bromcomp HC, Endacof HC, Brovex HC, Pseubrom, Shellcap PD, Seradex-LA, Vazobid-PD, Dime Time Extended Release, Tanabid SR, Brotapp PE, Brohist D, Alenaze-D, RespaHist II, Unit-Tex 10/120 ER, Dibrom, Brotapp, Brovex SR, Dimaphen, VazoTuss HC, Bromhist-NR, ENT, Altatapp, Myphetapp, Brom Tann PE, Phenyl 15/12mg, Endafed, Bromhist Pediatric, BroveX PSB, Touro A&H, Allent, Dimetane Decongestant, Vazotab, BroveX ADT, BroveX PD, BroveX PSE, Di-Bromm, BroveX PEB, Zotex-PE, LoHist PSB, Brofed, Lodrane 12D, Bidhist-D, Bromfed PD, BroveX-D, Bromaxefed DM RF Syrup, EndaCof-PD, Allanhist PDX Syrup, Bromhist-PDX, Acutuss DM Pediatric, Uni-Hist DM Pediatric Syrup, Uni-Hist PDX Syrup, AccuHist PDX Syrup, Trihist-CS, Poly-Histine CS, Liquihistine CS, Poly CS, Polytine CS, AccuHist DM Pediatric Syrup, Pediahist DM Syrup, Dur-Tann DM, Bromtuss DM, Tussi-Pres B, BroveX PEB DM, BPM PE DM, Tusdec-DM, TL-Hist DM, BPM DM PHEN, BroveX PB DM, Duravent DPB, Alacol DM, BP Allergy DM, Myphetane DC, Dimetane DC, LoHist-12, B-Vex, Lodrane 12 Hour, Brovex CT, Siltane, Cophene B, Codimal A, P-Tex, Dristan Cold Maximum Strength, Bromaphen, Tanacof-XR, Veltane, Respa BR, Lodrane XR, EndaCof-AC, BroveX CBX, BroveX PB C, BroveX PB CX, TL-Hist CD, BroveX CB, SymPak II, BetaTan, Trexbrom (old formulation), Vazotan, Trexbrom, Dicel CD, Balacall DM, Brotapp PE-DM, Carbofed DM Syrup, Bromaline DM, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, PSE Brom DM, Comtrex Acute Head Cold, Bromadine-DM, Liquiphed DM, Bromphenex DM, Andehist DM NR Syrup, Bromtapp-DM, Pediahist DM Drops, Bromph DM, Tusnel-HC, EndaCof-DH, VasoTuss HC, BPM PE HC, Canges-HC NR, Poly-Tussin DHC, Centussin DHC, Allanhist PDX Drops, Uni-Hist PDX Drops, Histacol BD Drops, Brom Tann, Sildec DM, Bromophed-DX, Myphetane DX Cough, Iohist DM, Polytine DM, KG Hist DM, Uni Multihist DM, Liquihistine DM, Delhistine DM, Highland DM, EndaCof-DM, Bromatan-DM, Histinex DM, Prohistine DM, Poly DM, Trihist DM, Durahistine DM, Bromdex D, Anaplex DMX, Neo DM Syrup, Myphetane DX, Bromanate DX Cough, PBM Allergy, BroveX PSE DM, EndaCof PD Drops, Dimetapp DM, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, FluTuss HC

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

Substance Name

Brompheniramine

CAS Registry Number

86-22-6

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

34

Last Revision Date

20130907

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